Date
Tuesday 19 January 2021 (Day 1)
Place
Microsoft Teams
Present members
Professor Marian Knight (Chair)
Professor Andrew Farmer (Programme Director)
Professor Catherine Hewitt (Deputy Chair)
Dr Ben Ainsworth
Mr Roshan Bootun
Professor Monica Busse
Mr Paul Charlton (Public Member)
Dr Emilio Fernandez-Egea
Dr Pollyanna Hardy
Professor Angela Hassiotis
Mr Rakesh Heer
Ms Debby Lennard (Public Member)
Professor Nick Maskell
Professor Jane Nixon
Professor Daniel Perry
Professor Rebecca Reynolds
Professor Chris Rogers
Professor Jonathan Ross
Professor Andrew Shennan
Professor Sobha Sivaprasad
Dr Beth Stuart
Dr Chris Sutton
Associate Professor Lyvonne Tume
Professor Nefyn Williams
NETSCC, HTA Secretariat
Dr Jason Horsley (Consultant Advisor)
Steph Garfield-Birkbeck (Head of the HTA Programme)
Karen Williams (Senior Research Manager)
Kathy Tier (Research Manager)
Connie Temple-Brown (Assistant Research Manager)
Louisa Saunders (Assistant Research Manager)
Apologies
Professor Joy Adamson
Professor Saul Faust
Professor Richard Grieve
Professor Pip Logan
Associate Professor Antonieta Medina-Lara
Dr Greta Rait
Observers
Jeremy Taylor (Director, CED l Jane Luff AD, Infrastructure and Faculty) 10-12pm
Quoracy Information
Voting members: 28 Quorum = 19
Voting members present on Day 1: 22 (79%)
Commissioned Stage 2 applications shortlisted at September 2020 Committee meeting
20/18 Minimally invasive operative interventions for bladder outlet obstruction due to benign prostatic hyperplasia
Chair: Professor Marian Knight
Declared a conflict and left the meeting: Professor Chris Rogers, Professor Rakesh Heer
Arrived at the Meeting: Jeremy Taylor (observer)
Left Meeting: Steph Garfield-Birkbeck
NIHR131984: Prostate Resection versus Minimally Invasive Surgery Evaluation Trial- PREMISE trial.
(Dr Tobias Page, The Newcastle Upon Tyne Hospitals NHS Foundation Trust)
Funding Committee recommendation: Decline Return to POC
20/19 Nasal decolonisation of MRSA
Chair: Professor Marian Knight
Declared a conflict and left the meeting: Dr Christopher Sutton, Professor Catherine Hewitt, Professor Jonathan Ross
NIHR132718: A multi-centre randomised controlled non-inferiority and cost effectiveness trial comparing Polyhexanide and Chlorhexidine with Neomycin to Mupiricon for nasal meticillin-resistant Staphylococcus aureus (MRSA) decolonisation amongst adult hospital in-patients
(Professor Mike Reed, Northumbria Healthcare NHS Foundation Trust)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/124 Effectiveness of meniscal allograft transplantation
Chair: Professor Catherine Hewitt
Declared a conflict and left the meeting: Dr Christopher Sutton, Professor Andrew Farmer, Professor Daniel Perry, Professor Marian Knight
NIHR131629: The Meniscal Transplant surgery or Optimised Rehabilitation full randomised trial (MeTeOR2)
(Mr Andrew Metcalfe, University of Warwick)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/120 Relapsing polymyalgia rheumatica
Chair: Professor Catherine Hewitt
Declared a conflict and left the meeting: Professor Andrew Farmer, Professor Jane Nixon, Professor Marian Knight, Professor Rakesh Heer
Left meeting: Chris Sutton
NIHR131475: Steroid-Reducing Options for ReLapsING PMR (STERLING-PMR): a pragmatic, randomised trial to compare the clinical and cost-effectiveness of adding immunosuppression to steroid-tapering treatment for patients with relapsing PMR, versus steroid-tapering alone.
(Dr Sarah Mackie, University of Leeds)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
20/26 Antifungal Stewardship in Haemato-oncology
Chair: Professor Marian Knight
Declared a conflict and left the meeting: Dr Christopher Sutton, Professor Catherine Hewitt
Arrived at meeting: Steph Garfield-Birkbeck
NIHR132329: Improving Antifungal Stewardship in Haemato-oncology using a Biomarker-guided algorithm Versus Empirical treatment (I-SAVE)
(Dr Samir Agrawal, Barts & The London School of Medicine & Dentistry)
Funding Committee recommendation: Decline
NIHR132674: Biomarker Driven Antifungal Stewardship in AML: The BioDriveAFS Trial
(Dr Gavin Barlow, Hull York Medical School)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
20/24: Psychological intervention for complex post-traumatic stress disorder
Chair: Professor Catherine Hewitt
Declared a conflict and left the meeting: Dr Ben Ainsworth, Ms Debby Lennard, Professor Andrew Farmer, Professor Jonathan Ross, Professor Marian Knight, Professor Monica Busse, Professor Nefyn Williams, Professor Rebecca Reynolds
Returned to meeting: Chris Sutton
Left meeting: Jeremy Taylor (Observer)
NIHR132705: Does a Phased Approach Enhance Outcomes for Trauma-Focused Cognitive Therapy for Complex Posttraumatic Stress Disorder?
(Professor Anke Ehlers, University of Oxford)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
NIHR131977: Randomised controlled trial of enhanced skills training in affective and interpersonal regulation coupled with exposure work (ESTAIR) versus trauma focused cognitive behavioural therapy (TFCBT) for complex post-traumatic stress disorder (CPTSD).
(Professor Jonathan Bisson, Cardiff University)
Funding Committee recommendation: Decline
20/23 Diagnostic tools to establish the presence and severity of peripheral arterial disease in people with diabetes
Chair: Professor Marian Knight
Declared a conflict and left the meeting: Mr Roshan Bootun, Professor Chris Rogers, Professor Jane Nixon, Professor Jonathan Ross, Professor Nick Maskell, Professor Rakesh Heer, Professor Rebecca Reynolds
NIHR131855: Diagnostic tools to establish the presence and severity of peripheral arterial disease in people with diabetes
(Mr Usman Jaffer, Imperial College Healthcare NHS Trust)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
NIHR132140: Peripheral Arterial Disease in Diabetes Mellitus: Diagnosis and Assessment of Severity. The PAD DIAGNOSE study.
(Mr Patrick Coughlin, Cambridge University Hospital Trusts)
Funding Committee recommendation: Decline
20/25: Guided self-help for depression in adults with autism spectrum disorders
Chair: Professor Marian Knight
Declared a conflict and left the meeting: Dr Ben Ainsworth, Professor Angela Hassiotis, Professor Chris Rogers, Professor Nick Maskell
Arrived at meeting: Andrew Shennan
NIHR132343: A randomised controlled trial of guided self-help for depression for autistic adults
(Dr Ailsa Russell, University of Bath)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
20/27 Management of ankle fractures in children
Chair: Professor Chris Rogers
Declared a conflict and left the meeting: Professor Andrew Farmer, Professor Catherine Hewitt, Professor Daniel Perry, Professor Marian Knight, Professor Nefyn Williams
NIHR132675: Outcomes of Displaced Distal tibial fractures - Surgery Or Casts in KidS (ODD SOCKS). A multi-centre prospective randomized superiority trial of conservative versus surgical treatment for displaced distal tibial fractures in children.
(Mr Nicholas Peterson, Alder Hey Children's NHS Foundation Trust)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/128 Administration routes of steroids in the first-line treatment of idiopathic sensorineural hearing loss
Chair: Professor Marian Knight
Declared a conflict and left the meeting: Dr Christopher Sutton, Ms Pollyanna Hardy, Professor Greta Rait, Professor Jonathan Ross, Professor Rakesh Heer
Left meeting: Monica Busse-Morris
NIHR131528: Administration routes of steroids in the first-line treatment of idiopathic sudden sensorineural hearing loss
(Mr James Tysome, Cambridge University Hospitals NHS Foundation Trust)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
NIHR131660: Steroids as a first-line treatment for idiopathic Sudden Sensorineural HEaring Loss – a randomised controlled double-blinded trial comparing routes of administration: the SeaSHeL trial
(Professor Anne Schilder, UCL Ear Institute)
Funding Committee recommendation: Decline
20/98 SIMS Trial Follow up call
Chair: Professor Catherine Hewitt
Declared a conflict and left the meeting: Professor Jonathan Ross, Professor Marian Knight, Professor Rebecca Reynolds
left meeting: Stephanie Garfield-Birbeck
NIHR133092: Long-Term Outcomes Of Synthetic Mid-Urethral Slings (Mesh Tapes) In Surgical Treatment Of Stress Urinary Incontinence In Women – A Long-term Follow-Up Of The SIMS RCT.
(Professor Mohamed Abdel-Fattah, University of Aberdeen)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
Date
Wednesday 20 January 2021 (Day 2)
Place
Microsoft Teams
Present members
Professor Marian Knight (Chair)
Professor Andrew Farmer (Programme Director)
Professor Catherine Hewitt (Deputy Chair)
Dr Ben Ainsworth
Mr Roshan Bootun
Professor Monica Busse
Mr Paul Charlton (Public Member)
Dr Emilio Fernandez-Egea
Professor Richard Grieve
Dr Pollyanna Hardy
Professor Angela Hassiotis
Mr Rakesh Heer
Ms Debby Lennard (Public Member)
Professor Nick Maskell
Professor Jane Nixon
Professor Daniel Perry
Professor Rebecca Reynolds
Professor Chris Rogers
Professor Jonathan Ross
Professor Andrew Shennan
Professor Sobha Sivaprasad
Dr Beth Stuart
Dr Chris Sutton
Associate Professor Lyvonne Tume
Professor Nefyn Williams
NETSCC, HTA Secretariat
Dr Jason Horsley (Consultant Advisor)
Steph Garfield-Birkbeck (Head of the HTA Programme)
Karen Williams (Senior Research Manager)
Kathy Tier (Research Manager)
Connie Temple-Brown (Assistant Research Manager)
Louisa Saunders (Assistant Research Manager)
Apologies
Professor Joy Adamson
Professor Saul Faust
Professor Pip Logan
Associate Professor Antonieta Medina-Lara
Dr Greta Rait
Observers
Professor Rupert Pearse (Deputy Chair, General Funding Committee) morning only
Quoracy Information
Voting members: 28 Quorum = 19
Voting members present on Day 2: 23 (82%)
Commissioned Stage 2 applications shortlisted at September 2020 Committee meeting continued
20/21 Subcutaneous vs oral methotrexate for rheumatoid arthritis
Chair: Professor Catherine Hewitt
Declared a conflict and left the meeting: Dr Christopher Sutton, Professor Jonathan Ross
Arrived at meeting: Rupert Pearse (observer)
Left Meeting: Dan Perry, Steph Garfield-Birkbeck
NIHR132711: Multi-centre randomised open-label assessor-blinded two arm parallel group trial of subcutaneous versus oral methotrexate for rheumatoid arthritis (RA), with feasibility assessment, economic evaluation and qualitative study.
Short-title: Methotrexate Oral Or SubcutanEous for RA [The MOOSE study].
(Professor Abhishek Abhishek, University of Nottingham)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
NIHR132072: COmparison of Subcutaneous Methotrexate compared with oral methotrexate treatment strategy In patients with early rheumatoid arthritis, aiming for remission: an open label Clinical trial. The COSMIC trial.
(Dr Suzanne Verstappen, The University of Manchester)
Funding Committee recommendation: Decline
Commissioning Stage 1 applications – received from November call close
20/96 Partial vs radical nephrectomy for clinically localised renal cell carcinoma
Chair: Professor Marian Knight
Declared a conflict and left the meeting: Professor Nick Maskell, Professor Rakesh Heer
Arrived at meeting: Dan Perry,
NIHR133322: A multi-centre, open-label, pragmatic cohort embedded randomized controlled, parallel-group, non-inferiority phase III trial to compare the efficacy of PaRtial versus tOtal nePhrectomy for clinically localisEd moderately complex renal cancer, incorporating a 1 year internal pilot (PROPER) trial
(Associate Professor Maxine Tran, University College London)
Funding Committee recommendation: Shortlist
NIHR133561: The PARTIAL study – a randomised trial of clinical and cost effectiveness of PARTIAL vs total nephrectomy for clinically localised renal cell carcinoma
(Professor Naeem Soomro, The Newcastle Upon Tyne Hospitals NHS Foundation Trust)
Funding Committee recommendation: Shortlist
20/73 Surgery for endometrioma in women undergoing IVF
Chair: Professor Catherine Hewitt
Declared a conflict and left the meeting: Dr Christopher Sutton, Ms Pollyanna Hardy, Professor Greta Rait, Professor Jonathan Ross, Professor Rakesh Heer, Professor Rebecca Reynolds
Arrived at meeting: Steph Garfield-Birkbeck
NIHR133621: Surgery for endometrioma in women undergoing IVF
(Professor Abha Maheshwari, NHS Grampian)
Funding Committee recommendation: Shortlist
20/22 Rectus Sheath Blockade in Emergency Laparotomy
Chair: Professor Marian Knight
Declared a conflict and left the meeting: Dr Christopher Sutton, Ms Debby Lennard, Ms Pollyanna Hardy, Professor Andrew Farmer, Professor Chris Rogers, Professor Daniel Perry, Professor Jane Nixon, Professor Jonathan Ross, Professor Nefyn Williams, Professor Nick Maskell, Professor Rebecca Reynolds
NIHR132347: Rectus Sheath Catheters as post-operative analgesia in patients undergoing emergency laparotomy (RESECT trial)
(Miss Kiran Altaf, Liverpool University Hospitals Foundation Trust)
Funding Committee recommendation: Decline
NIHR133554: CAMELOT - Continuous rectus sheath Analgesia in eMErgency LaparOTomy Multi-centre, randomised sham-controlled trial of rectus sheath catheter-delivered local anaesthetic infusion compared with usual care in patients undergoing emergency bowel surgery
(Dr Mark Edwards, University Hospital Southampton NHS Foundation Trust)
Funding Committee recommendation: Shortlist
NIHR133625: RELAY Trial (Rectus sheath catheters in Emergency LAparotomY).
A multicentre, open label, pragmatic, two arm, parallel group, randomised controlled trial with an internal pilot and economic evaluation.
(Dr Ciro Morgese, University Hospitals Birmingham NHS Foundation Trust)
Funding Committee recommendation: Shortlist
NIHR133637: A randomised trial of rectus sheath blockade in emergency midline laparotomy
(Mr Hugh Paterson, The University of Edinburgh)
Funding Committee recommendation: Decline
NIHR133646: A prospective, multicentre, double blind, randomised controlled trial in emergency LAparotomy looking at Patient Reported Outcome measures following Rectus sheath BLOCKade (LAPROBLOCK)
(Dr Shiva Tripathi, Lancashire Teaching Hospitals NHS Foundation Trust)
Funding Committee recommendation: Decline
20/75 Conservative management of primary spontaneous pneumothorax
Chair: Professor Catherine Hewitt
Declared a conflict and left the meeting: Professor Andrew Farmer, Professor Chris Rogers, Professor Marian Knight, Professor Nick Maskell
NIHR133653: “CONservative versus Standard carE for primary spontaneous PneumoThorax” (CONSEPT)
(Professor Nick Maskell, University of Bristol)
Funding Committee recommendation: Shortlist
20/72 Oxybutynin for the treatment of vasomotor symptoms associated with menopause
Chair: Professor Catherine Hewitt
Declared a conflict and left the meeting: Dr Christopher Sutton, Ms Pollyanna Hardy, Professor Jonathan Ross, Professor Marian Knight
NIHR133638: Can Oxybutynin or alternative drugs lessen menOpausal hot fLushes: the COOL trial
(Professor T Justin Clark, Birmingham Women's NHS Foundation Trust)
Funding Committee recommendation: Decline
NIHR133461: Oxybutynin or antidepressants for hot flushes in women who cannot or choose not to use hormone replacement therapy: randomised trial and economic evaluation (the BLUSH trial)
(Dr Melanie Davies, University College London Hospitals NHS Foundation Trust)
Funding Committee recommendation: Shortlist
20/74 Antidepressants for post-stroke emotionalism
Chair: Professor Catherine Hewitt
Declared a conflict and left the meeting: Dr Christopher Sutton, Ms Debby Lennard, Professor Jane Nixon, Professor Rebecca Reynolds
Left meeting: Angela Hassiotis
NIHR133015: A multi-centre, international, randomised, double-blind, placebo-controlled trial to establish the effect(s) of administration of sertraline (50 mg once daily) in people with a recent stroke and post-stroke emotionalism
(Professor Niall Broomfield, Norwich Medical School, University of East Anglia)
Funding Committee recommendation: Shortlist
20/76 Reverse vs conventional shoulder replacement for adults with osteoarthritis
Chair: Professor Marian Knight
Declared a conflict and left the meeting: Dr Christopher Sutton, Professor Andrew Farmer, Professor Catherine Hewitt, Professor Daniel Perry, Professor Jonathan Ross
NIHR133337: Conventional versus reverse total shoulder arthroplasty trial (ConVeRTS)
(Associate Professor David Ellard, University of Warwick)
Funding Committee recommendation: Shortlist
NIHR133418: Reverse or Anatomical (replacement) for Painful Shoulder Osteoarthritis: Differences between Interventions. Acronym; RAPSODI
(Professor Ian Trail, Wrightington, Wigan & Leigh NHS Foundation Trust)
Funding Committee recommendation: Shortlist
NIHR133608: The ROTATOR Trial - Reverse Or Total AnaTomic for Osteoarthritis with intact Rotator cuff
(Mr Christopher Smith, Royal Devon and Exeter NHS Foundation Trust)
Funding Committee recommendation: Decline