HTA Remit and Competitiveness Teleconference for NETS3 HTA Tobacco Cessation, control and harm reduction interventions, Researcher-Led Primary Research and Evidence Synthesis Applications from the May 2019 Call Close
Date and time
Wednesday 05 June 2019, 10:00-13:00
Place
Haygarth room, Beta House
Present
Professor Hywel Williams (Chair)
Professor Steve Goodacre
Professor Lucy Chappell
Professor Andrew Farmer
Dr Ira Madan
Dr Geoff Wong
Professor David Sebag-Montefiore
NETSCC
Dr Martin Ashton-Key (Consultant Advisor)
Mrs Karen Williams (Senior Research Manager)
Dr Cristina Lujan Barroso (Research Manager)
Miss Louisa Saunders (Assistant Research Manager)
Observers
None
Apologies
Associate Professor Kamal Mahtani, Professor Andrew Bradbury, Dr Simon Fraser, Miss Louise Maclachlan, Ms Maria Oosterwijk
18/166 HTA Tobacco Cessation, control and harm reduction intervention
NIHR129166 - E-cigarettes for Quitting Smoking in Young People: A Randomised Controlled Trial (EQuiYP)
Dr Lynne Dawkins
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Out of Remit
18/166 HTA Tobacco Cessation, control and harm reduction intervention
NIHR129438 - Smoking cessation in the Emergency Department: a randomised controlled trial
Dr Ian Pope
Chair: Hywel Williams
Declared a conflict and left the call: Steve Goodacre
Recommendation: Proceed to Funding Committee
18/166 HTA Tobacco Cessation, control and harm reduction intervention
NIHR129593 - Investigating the effectiveness of electronic cigarettes as an aid to smoking cessation in comparison with varenicline and the effect of vaping on lung health in patients with chronic obstructive pulmonary disease (E-CaL study)
Dr Amanda Farley
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Proceed to Funding Committee
18/166 HTA Tobacco Cessation, control and harm reduction intervention
NIHR129607 - E-cigarettes plus behavioural and psychological support for smoking cessation for users of community secondary mental health care: A cluster-randomised and controlled trial feasibility study
Dr Gemma Taylor
Chair: Hywel Williams
Declared a conflict and left the call: Andrew Farmer, Geoff Wong
Recommendation: Out of Remit
18/166 HTA Tobacco Cessation, control and harm reduction intervention
NIHR129627 - Do e-cigarettes help smokers quit when not accompanied by intensive behavioural support?
Dr Katie Myers Smith
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Proceed to Funding Committee
18/166 HTA Tobacco Cessation, control and harm reduction intervention
NIHR129636 - Examining feasibility, efficacy, clinical-effectiveness and cost-effectiveness of a novel digital platform for the delivery of assessment, triage and intervention for population-wide smoking cessation support: ‘My Quit Route’
Mrs Stephanie Dugdale
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Out of Remit
18/166 HTA Tobacco Cessation, control and harm reduction intervention
NIHR129735 - Health effects of short-term and long-term use of e-cigarettes
Professor Peter Hajek
Chair: Hywel Williams
Declared a conflict and left the call: Andrew Farmer, Geoff Wong
Recommendation: Proceed to Funding Committee
18/166 HTA Tobacco Cessation, control and harm reduction intervention
NIHR129210 - Open-label, randomised controlled trial of nicotine replacement therapy preloading and lapse recovery for cessation and where quitting fails, for smoking reduction in pregnancy
Professor Tim Coleman
Chair: Steve Goodacre
Declared a conflict and left the call: Hywel Williams, Andrew Farmer, Geoff Wong
Recommendation: Proceed to Funding Committee
19/11 HTA Researcher-led call Primary Research
NIHR129025 - WrIst Physiotherapy Interventions in Trauma (WIPIT Study)
Associate-Professor Ben Ollivere
Chair: Steve Goodacre
Declared a conflict and left the call: Hywel Williams
Recommendation: Proceed to Funding Committee
19/11 HTA Researcher-led call Primary Research
NIHR128977 - EDAM: Evaluating Dislocated Acromioclavicular joint Management
Associate-Professor Rebecca Kearney
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129001 - Post-stroke Intervention Trial in fatigue (POSITIF): a randomised controlled trial of a guided self help intervention for treating post-stroke fatigue
Professor Gillian Mead
Chair: Hywel Williams
Declared a conflict and left the call: Geoff Wong
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129114 - SISTAR: Outcomes of simultaneous versus staged resections for synchronous colorectal liver metastases – a randomised controlled trial
Mr Giuseppe Fusai
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Proceed to Funding Committee
19/11 HTA Researcher-led call Primary Research
NIHR129172 - A radical Steroid AVoidance trial in ANti-Neutrophil cytoplasm Antibody (ANCA) associated vasculitis (SAVANNA)
Professor Alan Salama
Chair: Hywel Williams
Declared a conflict and left the call: Lucy Chappell
Recommendation: Uncompetitive
19/11 HTA Researcher-led call Primary Research
NIHR129189 - Quetiapine augmentation of antidepressants for treatment resistant depression
Professor Glyn Lewis
Chair: Hywel Williams
Declared a conflict and left the call: Lucy Chappell
Recommendation: Uncompetitive
19/11 HTA Researcher-led call Primary Research
NIHR129197 - Children’s Ear Drops for eAR pain2 (CEDAR2): pragmatic randomised controlled trial
Professor Alastair Hay
Chair: Hywel Williams
Declared a conflict and left the call: Lucy Chappell
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129693 - BUDSURF - Randomised controlled trial of Budesonide-Surfactant for the prevention of Chronic Lung Disease in extreme preterm infants
Dr Mallinath Chakraborty
Chair: Hywel Williams
Declared a conflict and left the call: Lucy Chappell
Recommendation: Uncompetitive
19/11 HTA Researcher-led call Primary Research
NIHR129731 - Maternal POsition in the second stage of labour in nulliparous Women Without EpiduRal analgeSia: a randomised controlled trial (POWWERS)
Dr Caroline Fox
Chair: Andrew Bradbury
Declared a conflict and left the call: Lucy Chappell
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129237 - A randomised controlled trial of low intensity psychological treatment for depression for autistic adults
Dr Ailsa Russell
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Uncompetitive
19/11 HTA Researcher-led call Primary Research
NIHR129385 - RAPTOR: Randomised Controlled Trial of PENTOCLO in Mandibular Osteoradionecrosis
Professor Richard Shaw
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Proceed to Funding Committee
19/11 HTA Researcher-led call Primary Research
NIHR129518 - A randomised controlled trial to determine the effect and cost-effectiveness of liberal and conservative perioperative oxygen therapy on clinical outcomes following major surgery.
Dr Daniel Martin
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Proceed to Funding Committee
19/11 HTA Researcher-led call Primary Research
NIHR129531 - Long-term outcomes following breast conservation versus mastectomy in women aged 40 years or under with breast cancer stratified by BRCA status: POSH study follow-up extension
Dr Ellen Copson
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Uncompetitive
19/11 HTA Researcher-led call Primary Research
NIHR129550 - MIDAS Trial: Modifying pain using Drugs Around Surgery. A randomised, double-blind, placebo-controlled trial of ibuprofen to safely reduce pain after major gastrointestinal surgery.
Dr Michael Gillies
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Proceed to Funding Committee
19/11 HTA Researcher-led call Primary Research
NIHR129551 - CanACT2: Acceptance and Commitment Therapy versus treatment as usual for psychosocial dysfunction in people with advanced cancer; a randomised controlled trial.
Dr Marc Serfaty
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129557 - Evaluating the role of fast MRI and image-fusion biopsy for the detection of prostate cancer
Professor Hashim Ahmed
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129564 - Use of high-flow humidified oxygen TheRapy versus stAndard Care following major HEad & neck surgery: A multi-site randomIsed controlled tRial (TRACHE-AIR)
Mr Paul Twose
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129580 - WHiTE 12-WHISH: Wound Healing in Surgery for Hip fractures
Professor Matthew Costa
Chair: Hywel Williams
Declared a conflict and left the call: Andrew Farmer
Recommendation: Uncompetitive
19/11 HTA Researcher-led call Primary Research
NIHR129589 - ORBITA-2: A placebo-controlled trial of percutaneous coronary intervention for the relief of stable angina
Professor Darrel Francis
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Proceed to Funding Committee
19/11 HTA Researcher-led call Primary Research
NIHR129576 - ENCOMPASS (MYELOMA). EvaluatioN of COMorbidity and suPportive therApy StrategieS in MYELOMA
Professor Gordon Cook
Chair: Hywel Williams
Declared a conflict and left the call: Steve Goodacre, David Sebag-Montefiore
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129002 - Exploring the effectiveness and cost-effectiveness of a community-based, exercise intervention with an embedded qualitative process evaluation for people with systemic sclerosis (EXCEL - SSc)
Dr Markos Klonizakis
Chair: Hywel Williams
Declared a conflict and left the call: Steve Goodacre
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129711 - The NOTES Study: Neonatal Outcomes with Treatments for Epileptic Seizures. A randomised controlled trial of phenobarbital and levetiracetam for seizures associated with neonatal hypoxic ischaemic encephalopathy and their association with neuro-development outcome at 2 years
Dr Anthony Hart
Chair: Hywel Williams
Declared a conflict and left the call: Steve Goodacre
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129592 - Cervical Orthoses in the Management of FragilitY Fractures of the Odontoid Process (COMFY)
Mr James Tomlinson
Chair: Andrew Farmer
Declared a conflict and left the call: Hywel Williams, Steve Goodacre
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129617 - Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administration for critically ill patients with Acute Kidney Injury (MOSAICC – Multicentre evaluation Of Sodium bicarbonate in Acute kidney Injury in Critical Care)
Professor Lui Forni
Chair: Steve Goodacre
Declared a conflict and left the call: Hywel Williams
Recommendation: Proceed to Funding Committee
19/11 HTA Researcher-led call Primary Research
NIHR129677 - MUlticentre randomised trial of Surveillance in Inflammatory Bowel Disease (IBD): a comparison of dye spray chromoendoscopy (DCE) versus dyeless virtual electronic chromoendoscopy (VCE) (MUSIc) for precise detection and outcome of colonic neoplasia in IBD patients
Associate-Professor Marietta Iacucci
Chair: Steve Goodacre
Declared a conflict and left the call: Hywel Williams
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129683 - Full Title: A cluster randomised controlled trial of using the enhanced liver fibrosis test in primary care to identify people at risk of liver fibrosis due to alcohol use disorders. Short title: DELIVER DEtecting LIVer damage using ELF In patients at RISK
Professor William Rosenberg
Chair: Steve Goodacre
Declared a conflict and left the call: Hywel Williams
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129628 - LIVACOR Trial: Minimally invasive LIVer And simultaneous COlorectal Resection
Professor Mohammed Abu Hilal
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Uncompetitive
19/11 HTA Researcher-led call Primary Research
NIHR129640 - Whole-body MRI for more efficient staging of breast cancer: internal pilot to inform a prospective multicentre comparison with standard imaging pathways.
Professor Steve Halligan
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129664 - The Effectiveness of Peroneal Nerve Functional Electrical STimulation (FES) for the Reduction of Bradykinesia in Parkinson’s DiSease: A Pragmatic Assessor Blinded Randomised Controlled Trial (STEPS II).
Professor Paul Taylor
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129668 - The use of 3D-printed insoles to prevent primary diabetic foot ulcers: a feasibility study.
Dr Panagiotis Chatzistergos
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129679 - A pragmatic multi-centre randomised controlled trial of alcohol assertive outreach treatment for patients admitted to hospital with alcohol-related liver disease (A-LIVE)
Professor Colin Drummond
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129690 - Diabetes Remission Clinical Trial for South Asians: The DISHA study
Professor Kamlesh Khunti
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Uncompetitive
19/11 HTA Researcher-led call Primary Research
NIHR129701 - Evidence-based pain management pathway for people with chronic pancreatitis
Professor Kurinchi Gurusamy
Chair: Hywel Williams
Declared a conflict and left the call: Geoff Wong
Recommendation: Proceed to Funding Committee - Commissioning
19/11 HTA Researcher-led call Primary Research
NIHR129707 - UrodynAmicS as Routine Evaluation in Women with StrEss UrinaRy InconTinence (The ASSERT Study); a superiority randomised clinical trial to evaluate the clinical and cost effectiveness of routine urodynamic investigations in management of women with stress
Professor Mohamed Abdel-Fattah
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129710 - A randomised control trial to determine the influence of metformin on the growth of large abdominal aortic aneurysms in patients without diabetes who are unsuitable for surgical intervention (MEASURE – Metformin Effect on Aneurysm Size in patients Unfit for Repair)
Professor Robert Hinchliffe
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129727 - Improving outcomes for men undergoing Open AAA Repair using Prehabilitation
Mr Tristan Lane
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129728 - Impact of green tea extract on cognition and function in older adults at risk of cognitive decline and dementia: A randomised controlled trial
Dr Anne Corbett
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129748 - Surgeons Trial Of Prophylaxis for Epilepsy in seizure naïve patients with Meningioma: a randomised controlled trial (STOP’EM)
Mr Michael Jenkinson
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Proceed to Funding Committee
19/11 HTA Researcher-led call Primary Research
NIHR129753 - Social Prescribing for Children and Young People
Professor Barry Wright
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129756 – TENSION (Trial EmbolisatioN IN oSteOarthritis)
Dr Nolan Walker
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129718 - Music Interventions for Dementia and Depression in ELderly care (MIDDEL): International cluster-randomised trial - UK arm (MIDDEL-UK)
Professor Justine Schneider
Chair: Steve Goodacre
Declared a conflict and left the call: Hywel Williams
Recommendation: Proceed to Funding Committee
19/11 HTA Researcher-led call Primary Research
NIHR129079 - The AVERT (Acute VErtebral fragility fractuRe augmenTation) study in hospitalised patients.
Professor Opinder Sahota
Chair: Steve Goodacre
Declared a conflict and left the call: Hywel Williams
Recommendation: Out of Remit
19/11 HTA Researcher-led call Primary Research
NIHR129179 - PREDNOS 3: what is the optimal steroid treatment dose to induce remission in relapses of childhood nephrotic syndrome?
Dr Martin Christian
Chair: Steve Goodacre
Declared a conflict and left the call: Hywel Williams
Recommendation: Proceed to Funding Committee
19/10 HTA Researcher-led call Evidence Synthesis
NIHR129305 - Clinical and cost-effectiveness of early interventions initiated in the acute care period for managing the psychological effects of trauma and to reduce the incidence and duration of common mental disorders.
Dr Philippa Olive
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Uncompetitive
19/10 HTA Researcher-led call Evidence Synthesis
NIHR129523 - BEhavioural Weight Management: COMponents of Effectiveness (BE:COME)
Dr Jennifer Logue
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Proceed to Funding Committee
19/10 HTA Researcher-led call Evidence Synthesis
NIHR129646 - Evaluating diagnostic performance of imaging technologies for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment: a systematic review and meta-analysis
Dr Huiqin Yang
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Uncompetitive
19/10 HTA Researcher-led call Evidence Synthesis
NIHR129708 - Safety and effectiveness of tranexamic acid in trauma and surgery in the NHS: An individual patient data meta-analysis
Dr Katharine Ker
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Proceed to Funding Committee
19/10 HTA Researcher-led call Evidence Synthesis
NIHR129713 - Effectiveness and cost-effectiveness of gynaecological surveillance for women with Lynch syndrome: systematic reviews and economic evaluation
Dr Tristan Snowsill
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Proceed to Funding Committee
19/10 HTA Researcher-led call Evidence Synthesis
NIHR129715 - Diet and physical activity in pregnancy to prevent gestational diabetes: Individual Participant Data (IPD) meta-analysis on the differential effects of interventions with economic evaluation
Professor Shakila Thangaratinam
Chair: Hywel Williams
Declared a conflict and left the call: Lucy Chappell
Recommendation: Proceed to Funding Committee
19/10 HTA Researcher-led call Evidence Synthesis
NIHR129742 - Systematic Review and meta-analysis of clinical and cost effectiveness and feasibility of a UK extracorporeal cardiopulmonary resuscitation programme for out-of-hospital cardiac arrests
Associate-Professor Joyce Yeung
Chair: Hywel Williams
Declared a conflict and left the call: Steve Goodacre
Recommendation: Proceed to Funding Committee
19/11 HTA Researcher-led call Primary Research
NIHR129750 - Prostate cancer Risk Evaluation by Freehand transperineal sectoral (FHTP-24 core) versus Evaluation by Reduced (FHTP–12 core) biopsy: Randomisation for Effective Diagnosis. A randomised non-inferiority trial. Short Title: PREFERRED
Mr Rick Popert
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Uncompetitive
19/11 HTA Researcher-led call Primary Research
NIHR129649 - A multicentre randomised placebo-controlled trial of the effectiveness and cost-effectiveness of conventional vs high-frequency spinal cord stimulation in patients with neuropathic pain. CHESTNUT STUDY
Professor Sam Eldabe
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Proceed to Funding Committee
19/11 HTA Researcher-led call Primary Research
NIHR127873 - Pragmatic randomised trial of High Or Standard PHosphAte Targets in End-stage kidney disease - The PHOSPHATE trial
Dr Thomas Hiemstra
Chair: Hywel Williams
Declared a conflict and left the call: None
Recommendation: Proceed to Funding Committee
18/166 - HTA Tobacco Cessation, control and harm reduction interventions (NETS3 call) – Primary Research
1.1
NIHR129166
E-cigarettes for Quitting Smoking in Young People: A Randomised Controlled Trial (EQuiYP)
(Dr Lynne Dawkins)
Decision: Out of remit
1.2
NIHR129438
Smoking cessation in the Emergency Department: a randomised controlled trial
(Dr Ian Pope)
Decision: Proceed to Funding Committee
1.3
NIHR129593
Investigating the effectiveness of electronic cigarettes as an aid to smoking cessation in comparison with varenicline and the effect of vaping on lung health in patients with chronic obstructive pulmonary disease (E-CaL study)
(Dr Amanda Farley)
Decision: Proceed to Funding Committee
1.4
NIHR129607
E-cigarettes plus behavioural and psychological support for smoking cessation for users of community secondary mental health care: A cluster-randomised and controlled trial feasibility study
(Dr Gemma Taylor)
Decision: Out of remit
1.5
NIHR129627
Do e-cigarettes help smokers quit when not accompanied by intensive behavioural support?
(Dr Katie Myers Smith)
Decision: Proceed to Funding Committee
1.6
NIHR129636
Examining feasibility, efficacy, clinical-effectiveness and cost-effectiveness of a novel digital platform for the delivery of assessment, triage and intervention for population-wide smoking cessation support: ‘My Quit Route’
(Mrs Stephanie Dugdale)
Decision: Out of remit
1.7
NIHR129735
Health effects of short-term and long-term use of e-cigarettes
(Professor Peter Hajek)
Decision: Proceed to Funding Committee
1.8
NIHR129210
Open-label, randomised controlled trial of nicotine replacement therapy preloading and lapse recovery for cessation and where quitting fails, for smoking reduction in pregnancy
(Professor Tim Coleman)
Decision: Proceed to Funding Committee
19/11 HTA Researcher-led call - Primary Research
1.9
NIHR129025
WrIst Physiotherapy Interventions in Trauma (WIPIT Study)
(Associate-Professor Ben Ollivere)
Decision: Proceed to Funding Committee
1.10
NIHR128977
EDAM: Evaluating Dislocated Acromioclavicular joint Management
(Associate-Professor Rebecca Kearney)
Decision: Out of remit
1.11
NIHR129001
Post-stroke Intervention Trial in fatigue (POSITIF): a randomised controlled trial of a guided self help intervention for treating post-stroke fatigue
(Professor Gillian Mead)
Decision: Out of remit
1.12
NIHR129114
SISTAR: Outcomes of simultaneous versus staged resections for synchronous colorectal liver metastases – a randomised controlled trial
(Mr Giuseppe Fusai)
Decision: Proceed to Funding Committee
1.13
NIHR129172
A radical Steroid AVoidance trial in ANti-Neutrophil cytoplasm Antibody (ANCA) associated vasculitis (SAVANNA)
(Professor Alan Salama)
Decision: Uncompetitive
1.14
NIHR129189
Quetiapine augmentation of antidepressants for treatment resistant depression
(Professor Glyn Lewis)
Decision: Uncompetitive
1.15
NIHR129197
Children’s Ear Drops for eAR pain2 (CEDAR2): pragmatic randomised controlled trial
(Professor Alastair Hay)
Decision: Out of remit
1.16
NIHR129693
BUDSURF - Randomised controlled trial of Budesonide-Surfactant for the prevention of Chronic Lung Disease in extreme preterm infants
(Dr Mallinath Chakraborty)
Decision: Uncompetitive
1.17
NIHR129731
Maternal POsition in the second stage of labour in nulliparous Women Without EpiduRal analgeSia: a randomised controlled trial (POWWERS)
(Dr Caroline Fox)
Decision: Out of remit
1.18
NIHR129237
A randomised controlled trial of low intensity psychological treatment for depression for autistic adults
(Dr Ailsa Russell)
Decision: Uncompetitive
1.19
NIHR129385
RAPTOR: Randomised Controlled Trial of PENTOCLO in Mandibular Osteoradionecrosis
(Professor Richard Shaw)
Decision: Proceed to Funding Committee
1.20
NIHR129518
A randomised controlled trial to determine the effect and cost-effectiveness of liberal and conservative perioperative oxygen therapy on clinical outcomes following major surgery.
(Dr Daniel Martin)
Decision: Proceed to Funding Committee
1.21
NIHR129531
Long-term outcomes following breast conservation versus mastectomy in women aged 40 years or under with breast cancer stratified by BRCA status: POSH study follow-up extension
(Dr Ellen Copson)
Decision: Uncompetitive
1.22
NIHR129550
MIDAS Trial: Modifying pain using Drugs Around Surgery. A randomised, double-blind, placebo-controlled trial of ibuprofen to safely reduce pain after major gastrointestinal surgery.
(Dr Michael Gillies)
Decision: Proceed to Funding Committee
1.23
NIHR129551
CanACT2: Acceptance and Commitment Therapy versus treatment as usual for psychosocial dysfunction in people with advanced cancer; a randomised controlled trial.
(Dr Marc Serfaty)
Decision: Out of remit
1.24
NIHR129557
Evaluating the role of fast MRI and image-fusion biopsy for the detection of prostate cancer
(Professor Hashim Ahmed)
Decision: Out of remit
1.25
NIHR129564
Use of high-flow humidified oxygen TheRapy versus stAndard Care following major HEad & neck surgery: A multi-site randomIsed controlled tRial (TRACHE-AIR)
(Mr Paul Twose)
Decision: Out of remit
1.26
NIHR129580
WHiTE 12-WHISH: Wound Healing in Surgery for Hip fractures
(Professor Matthew Costa)
Decision: Uncompetitive
1.27
NIHR129589
ORBITA-2: A placebo-controlled trial of percutaneous coronary intervention for the relief of stable angina
(Professor Darrel Francis)
Decision: Proceed to Funding Committee
1.28
NIHR129576
ENCOMPASS (MYELOMA)
EvaluatioN of COMorbidity and suPportive therApy StrategieS in MYELOMA
(Professor Gordon Cook)
Decision: Out of remit
1.29
NIHR129002
Exploring the effectiveness and cost-effectiveness of a community-based, exercise intervention with an embedded qualitative process evaluation for people with systemic sclerosis (EXCEL - SSc)
(Dr Markos Klonizakis)
Decision: Out of remit
1.30
NIHR129711
The NOTES Study: Neonatal Outcomes with Treatments for Epileptic Seizures
A randomised controlled trial of phenobarbital and levetiracetam for seizures associated with neonatal hypoxic ischaemic encephalopathy and their association with neuro-developme
(Dr Anthony Hart)
Decision: Out of remit
1.31
NIHR129592
Cervical Orthoses in the Management of FragilitY Fractures of the Odontoid Process (COMFY)
(Mr James Tomlinson)
Decision: Out of remit
1.32
NIHR129617
Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administration for critically ill patients with Acute Kidney Injury (MOSAICC – Multicentre evaluation Of Sodium bicarbonate in Acute kidney Injury in Critical Care)
(Professor Lui Forni)
Decision: Proceed to Funding Committee
1.33
NIHR129677
MUlticentre randomised trial of Surveillance in Inflammatory Bowel Disease (IBD): a comparison of dye spray chromoendoscopy (DCE) versus dyeless virtual electronic chromoendoscopy (VCE) (MUSIc) for precise detection and outcome of colonic neoplasia in I
(Associate-Professor Marietta Iacucci)
Decision: Out of remit
1.34
NIHR129683
Full Title: A cluster randomised controlled trial of using the enhanced liver fibrosis test in primary care to identify people at risk of liver fibrosis due to alcohol use disorders. Short title: DELIVER DEtecting LIVer damage using ELF In patients at
(Professor William Rosenberg)
Decision: Out of remit
1.35
NIHR129628
LIVACOR Trial: Minimally invasive LIVer And simultaneous COlorectal Resection
(Professor Mohammed Abu Hilal)
Decision: Uncompetitive
1.36
NIHR129640
Whole-body MRI for more efficient staging of breast cancer: internal pilot to inform a prospective multicentre comparison with standard imaging pathways.
(Professor Steve Halligan)
Decision: Out of remit
1.37
NIHR129664
The Effectiveness of Peroneal Nerve Functional Electrical STimulation (FES) for the Reduction of Bradykinesia in Parkinson’s DiSease: A Pragmatic Assessor Blinded Randomised Controlled Trial (STEPS II).
(Professor Paul Taylor)
Decision: Out of remit
1.38
NIHR129668
The use of 3D-printed insoles to prevent primary diabetic foot ulcers: a feasibility study.
(Dr Panagiotis Chatzistergos)
Decision: Out of remit
1.39
NIHR129679
A pragmatic multi-centre randomised controlled trial of alcohol assertive outreach treatment for patients admitted to hospital with alcohol-related liver disease (A-LIVE)
(Professor Colin Drummond)
Decision: Out of remit
1.40
NIHR129690
Diabetes Remission Clinical Trial for South Asians: The DISHA study
(Professor Kamlesh Khunti)
Decision: Uncompetitive
1.41
NIHR129701
Evidence-based pain management pathway for people with chronic pancreatitis
(Professor Kurinchi Gurusamy)
Decision: Proceed to Funding Committee
1.42
NIHR129707
UrodynAmicS as Routine Evaluation in Women with StrEss UrinaRy InconTinence (The ASSERT Study); a superiority randomised clinical trial to evaluate the clinical and cost effectiveness of routine urodynamic investigations in management of women with stress
(Professor Mohamed Abdel-Fattah)
Decision: Proceed to Funding Committee
1.43
NIHR129710
A randomised control trial to determine the influence of metformin on the growth of large abdominal aortic aneurysms in patients without diabetes who are unsuitable for surgical intervention (MEASURE – Metformin Effect on Aneurysm Size in patients Unfi
(Professor Robert Hinchliffe)
Decision: Out of remit
1.44
NIHR129727
Improving outcomes for men undergoing Open AAA Repair using Prehabilitation
(Mr Tristan Lane)
Decision: Out of remit
1.45
NIHR129728
Impact of green tea extract on cognition and function in older adults at risk of cognitive decline and dementia: A randomised controlled trial
(Dr Anne Corbett)
Decision: Out of remit
1.46
NIHR129748
Surgeons Trial Of Prophylaxis for Epilepsy in seizure naïve patients with Meningioma: a randomised controlled trial (STOP’EM)
(Mr Michael Jenkinson)
Decision: Proceed to Funding Committee
1.47
NIHR129753
Social Prescribing for Children and Young People (Professor Barry Wright)
Decision: Out of remit
1.48
NIHR129756
TENSION (Trial EmbolisatioN IN oSteOarthritis)
(Dr Nolan Walker)
Decision: Out of remit
1.49
NIHR129718
Music Interventions for Dementia and Depression in ELderly care (MIDDEL): International cluster-randomised trial - UK arm (MIDDEL-UK)
(Professor Justine Schneider)
Decision: Proceed to Funding Committee
1.50
NIHR129079
The AVERT (Acute VErtebral fragility fractuRe augmenTation) study in hospitalised patients.
(Professor Opinder Sahota)
Decision: Out of remit
1.51
NIHR129179
PREDNOS 3: what is the optimal steroid treatment dose to induce remission in relapses of childhood nephrotic syndrome?
(Dr Martin Christian)
Decision: Proceed to Funding Committee
1.59
NIHR129750
Prostate cancer Risk Evaluation by Freehand transperineal sectoral (FHTP-24 core) versus Evaluation by Reduced (FHTP–12 core) biopsy: Randomisation for Effective Diagnosis. A randomised non-inferiority trial. Short Title: PREFERRED
(Mr Rick Popert)
Decision: Uncompetitive
19/10 HTA Researcher-led call - Evidence Synthesis
1.52
NIHR129305
Clinical and cost-effectiveness of early interventions initiated in the acute care period for managing the psychological effects of trauma and to reduce the incidence and duration of common mental disorders.
(Dr Philippa Olive)
Decision: Uncompetitive
1.53
NIHR129523
BEhavioural Weight Management: COMponents of Effectiveness (BE:COME)
(Dr Jennifer Logue)
Decision: Proceed to Funding Committee
1.54
NIHR129646
Evaluating diagnostic performance of imaging technologies for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment: a systematic review and meta-analysis
(Dr Huiqin Yang)
Decision: Uncompetitive
1.55
NIHR129708
Safety and effectiveness of tranexamic acid in trauma and surgery in the NHS: An individual patient data meta-analysis
(Dr Katharine Ker)
Decision: Proceed to Funding Committee
1.56
NIHR129713
Effectiveness and cost-effectiveness of gynaecological surveillance for women with Lynch syndrome: systematic reviews and economic evaluation
(Dr Tristan Snowsill)
Decision: Proceed to Funding Committee
1.57
NIHR129715
Diet and physical activity in pregnancy to prevent gestational diabetes: Individual Participant Data (IPD) meta-analysis on the differential effects of interventions with economic evaluation
(Professor Shakila Thangaratinam)
Decision: Proceed to Funding Committee
1.58
NIHR129742
Systematic Review and meta-analysis of clinical and cost effectiveness and feasibility of a UK extracorporeal cardiopulmonary resuscitation programme for out-of-hospital cardiac arrests
(Associate-Professor Joyce Yeung)
Decision: Proceed to Funding Committee
19/11 HTA Researcher-led call – Primary Research
1.60
NIHR129649
A multicentre randomised placebo-controlled trial of the effectiveness and cost-effectiveness of conventional vs high-frequency spinal cord stimulation in patients with neuropathic pain. CHESTNUT STUDY
(Professor Sam Eldabe)
Decision: Proceed to Funding Committee
1.61
NIHR127873
Pragmatic randomised trial of High Or Standard PHosphAte Targets in End-stage kidney disease - The PHOSPHATE trial
(Dr Thomas Hiemstra)
Decision: Proceed to Funding Committee