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Home > About us > Document library > HTA Remit and Competitiveness teleconference - Public minutes January 2021

HTA Remit and Competitiveness teleconference - Public minutes January 2021

Contents

Published: 29 January 2021

Version: 1.0 - January 2021

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Friday 29 January 2021 10am - 1pm

Present Members

Professor Andrew Farmer (HTA Programme Director) (Chair)
Professor Lucy Chappell (Chair of CET Funding Committee)
Professor Julia Brown (Chair of General Funding Committee Chair)
Associate Professor Kamal Mahtani (Chair of Prioritisation Committee A)
Professor Anthony De-Soyza (Chair of Prioritisation Committee B)

NETSCC Secretariat

Dr Nicholas Hicks (NETSCC Consultant Advisor)
Mrs Karen Williams (Senior Research Manager)
Dr Brogan Ashley (Research Manager)
Dr Cristina Lujan Barroso (Research Manager)
Observers: Richard Parnell
Laura Bradley
Nikita Belavate
Apologies: Gail Thornton (Observer)


20/28 Repair and rehabilitation of hand flexor tendon injury

NIHR133207 - Tendon Injury Psychological Support (TIPS): Multicentre randomised clinical trial and economic evaluation (Professor Rebecca Kearney)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Uncompetitive

20/89 HTA Researcher-led call Evidence Synthesis

NIHR133146 - A Systematic Review of Clinical and Cost Effectiveness of Vitamin D Supplementation to Prevent Recurrence of Colorectal Adenoma After Surgical Removal. (Ms Jayne Wilson)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Uncompetitive

20/90 HTA Researcher-led call Primary Research

NIHR133581 - Furosemide against Bumetanide for the treatment of recently decompensated heart failure (Dr David Wilson)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

20/90 HTA Researcher-led call Primary Research

NIHR133580 - Adjunctive Local Drug Treatment at the Time Of Endoscopic Surgery for Primary and Recurrent Bulbar Urethral Stricture in Men (ReBUS) (Mr Nadir Osman)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

20/90 HTA Researcher-led call Primary Research

NIHR133817 - Randomised trial of TRans Anal vs Vaginal rEpair of rectoceLe for chronic constipation (TRAVELS) (Mr Jon Lacy-Colson)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

20/90 HTA Researcher-led call Primary Research

NIHR133688 - Implementation of extracorporeal-cardiopulmonary resuscitation (E-CPR) in the NHS: a decision-analytic health economic modelling study (Dr Keith Couper)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Anthony De Soyza
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

20/90 HTA Researcher-led call Primary Research

NIHR133796 - A Phase III Randomized, Open Label, Multi-Centre Study of Apixaban Compared to Standard of Care for Thromboembolism Prevention in Patients with Newly Diagnosed Acute Lymphoblastic Leukemia (ALL) Treated with Pegylated L-Asparaginase, the ASTA trial (Dr Charlotte Bradbury)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

20/90 HTA Researcher-led call Primary Research

NIHR133374 - DISPATCH Trial: Randomised controlled trial evaluating addition of a tissue patch during pancreatic surgery (Mr Colin Wilson)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Uncompetitive

20/90 HTA Researcher-led call Primary Research

NIHR133797 - A randomised trial to compare the effectiveness of Gardasil-9 HPV vaccine versus no additional therapy in PREVENTing recurrence in patients with eradicated high-grade anogenital intraepithelial neoplasia (the PREVENT trial) (Dr Sadie Jones)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

20/90 HTA Researcher-led call Primary Research

NIHR133611 - Inpatient graduated compression stocking use as an adjunct to extended duration pharmacoprophylaxis for venous thromboembolism prevention – a multi-centre randomised controlled trial (Professor Alun Davies)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

20/89 HTA Researcher-led call Evidence Synthesis

NIHR133726 - A randomised controlled trial assessing the clinical and cost effectiveness of compression HOSiery to Treat varicose vein Symptoms - the HOSTS study (Professor Alun Davies)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell
Declared a conflict and left the call: None declared
Recommendation: Uncompetitive

20/90 HTA Researcher-led call Primary Research

NIHR133776 - Examining the benefit of graduated compression stockings in the Prevention of vEnous Thromboembolism in low-risk Surgical patients: a multicentre cluster randomised controlled trial (PETS Trial) (Professor Alun Davies)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

20/90 HTA Researcher-led call Primary Research

NIHR133691 - “Active Mums”: randomised controlled trial of the Active10 app to increase brisk walking in postnatal mothers who had high blood pressure in pregnancy. (Professor Pippa Oakeshott)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell
Declared a conflict and left the call: None declared
Recommendation: Out of Remit and Uncompetitive

20/90 HTA Researcher-led call Primary Research

NIHR133518 - ThOracic Umbrella RadIotherapy STudy in stage IV NSCLC - TOURIST (Dr David Woolf)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

20/90 HTA Researcher-led call Primary Research

NIHR133451 - Differentiating optimised treatments for obsessive-compulsive disorder: A randomised study of cognitive behaviour therapy, sertraline and their combination (DOTO) (Professor Naomi Fineberg)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell
Declared a conflict and left the call: None declared
Recommendation: Uncompetitive

20/90 HTA Researcher-led call Primary Research

NIHR133722 - Effects of maternal Mediterranean-style diet with nuts and olive oil on asthma, wheeze and allergy disorders in offspring: Follow-up of randomised trial with Individual Participant Data (IPD) meta-analysis (Professor Shakila Thangaratinam)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell
Declared a conflict and left the call: None declared
Recommendation: Uncompetitive

20/90 HTA Researcher-led call Primary Research

NIHR133739 - The effectiveness and cost-effectiveness of semaglutide 2.4mg therapy, in individuals with obesity or overweight and cardiometabolic co-morbidity, on long-term weight loss maintenance following total dietary replacement (TDR), and augmentation of weight loss in sub-optimal TDR responders (Professor Melanie Davies)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

20/90 HTA Researcher-led call Primary Research

NIHR133642 - PROMIS: Prostaglandin Pessary vs Oral Misoprostol for Induction of Labour at Term (Dr Andrew Sharp)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell, Marian Knight
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

20/28 Repair and rehabilitation of hand flexor tendon injury

NIHR133763 - A multicentre randomised controlled trial comparing Wide-awake Anaesthesia No Tourniquet (WALANT) versus General and Regional Anaesthesia for Flexor Tendon Repair (FLEXOR Trial) (Professor Afshin Mosahebi)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

20/28 Repair and rehabilitation of hand flexor tendon injury

NIHR133748 - Wide-Awake local anaesthesia no tourniquet Surgical technique and early functional Hand Use Rehabilitation Protocol for treatment of finger flexor tendon injuries in adults: a 2x2 factorial randomised trial (The WASHUP Study - Mr Jason Wong)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell, Anthony De Soyza
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

20/89 HTA Researcher-led call Evidence Synthesis

NIHR133672 - Persuading healthcare professionals in acute care settings to use alternatives to indwelling urinary catheters: evidence synthesis of behavioural change interventions and their clinical and cost effectiveness Short title: DE-DUCT: DEcreasing routinely useD Urinary CaTheters with behaviour change (Ms Sheila Wallace)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Anthony De Soyza
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

20/90 HTA Researcher-led call Primary Research

NIHR133704 - Supporting parents with infant sleep and their mental health: an RCT and economic evaluation of a new intervention (SuPar Trial) (Professor Nicholas Embleton)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Anthony De Soyza
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

20/89 HTA Researcher-led call Evidence Synthesis

NIHR133436 - Percutaneous bipolar radiofrequency ablation for treating biliary obstruction caused by unresectable cancer: an evidence synthesis and value of information analysis (Dr John Leeds)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Anthony De Soyza, Kamal Mahtani
Declared a conflict and left the call: None declared
Recommendation: Uncompetitive

20/90 HTA Researcher-led call Primary Research

NIHR133708 - Stepped Care for comorbid mental and physical health disorders in children and young people (StepChange) (Professor Roz Shafran)

Chair: Lucy Chappell
Declared a conflict, remained in the teleconference: Kamal Mahtani
Declared a conflict and left the call: Andrew Farmer
Recommendation: Proceed to Funding Committee

20/28 Repair and rehabilitation of hand flexor tendon injury

NIHR133784 - A 2 x 2 factorial randomised trial to determine the clinical and cost effectiveness of not repairing flexor digitorum superficialis and a new rehabilitation regime versus usual care for treatment of complete zone II flexor tendon injuries: the FLexor repAir and REhabilitation (FLARE) Trial (Mr Matthew Gardiner)

Chair: Lucy Chappell
Declared a conflict, remained in the teleconference: Julia Brown, Kamal Mahtani, Marian Knight
Declared a conflict and left the call: Andrew Farmer
Recommendation: Proceed to Funding Committee

20/90 HTA Researcher-led call Primary Research

NIHR133741 - ICaRAS 2 (Intravenous Iron for Cancer Related Anaemia Symptoms) A Double Blind Multicentre Randomised Placebo Controlled Trial of Intravenous Iron Therapy for Anaemia in Palliative Cancer Care. (Associate-Professor Austin Acheson)

Chair: Lucy Chappell
Declared a conflict, remained in the teleconference: Marian Knight
Declared a conflict and left the call: Andrew Farmer
Recommendation: Uncompetitive

20/90 HTA Researcher-led call Primary Research

NIHR133666 - Maximising Extent of Resection using intra-operative Imaging Technology in Brain Tumours (MERIT BT) (Honorary Professor Conor Mallucci)

Chair: Lucy Chappell
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Andrew Farmer
Recommendation: Proceed to Funding Committee

20/90 HTA Researcher-led call Primary Research

NIHR133719 - Staphylococcus aureus Network Adaptive Platform (SNAP) Trial (Dr Anna Goodman)

Chair: Julia Brown
Declared a conflict, remained in the teleconference: Lucy Chappell
Declared a conflict and left the call: Andrew Farmer
Recommendation: Proceed to Funding Committee

20/90 HTA Researcher-led call Primary Research

NIHR133467 - The clinical and cost-effectiveness and safety of haematopoietic interventions administered to recovering patients with anaemia following major non-elective surgery: a phase IV, adaptive randomised controlled multicentre study. (Professor Iain Moppett)

Chair: Julia Brown
Declared a conflict, remained in the teleconference: Lucy Chappell, Kamal Mahtani, Marian Knight
Declared a conflict and left the call: Andrew Farmer
Recommendation: Proceed to Funding Committee

20/90 HTA Researcher-led call Primary Research

NIHR133711 - A randomised controlled trial to evaluate the safety of nasogastric tube omission and the effectiveness of pyloric intervention after oesophageal resection. (Mr James Gossage)

Chair: Julia Brown
Declared a conflict, remained in the teleconference: Lucy Chappell, Kamal Mahtani, Marian Knight
Declared a conflict and left the call: Andrew Farmer
Recommendation: Uncompetitive

20/90 HTA Researcher-led call Primary Research

NIHR133464 - Test-guided dietary advice in children with eczema: randomised controlled trial with internal pilot and nested economic and process evaluation (Dr Matthew Ridd)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Kamal Mahtani, Gail Thornton
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

20/90 HTA Researcher-led call Primary Research

NIHR133599 - The Utility Of Frequency-Modulated Electromagnetic Neural Stimulation (FREMS) As A Third Line Treatment In Patients With Painful Diabetes-Related Peripheral Neuropathy: A Randomised Controlled Trial (FREMS-PDPN) (Dr Abd Tahrani)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell, Marian Knight
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

20/90 HTA Researcher-led call Primary Research

NIHR133774 - Optimising Prescription of Treatment In older patients with Mild hypertension at Increased risk of Serious adverse Events (OPTIMISE2): a non-inferiority trial (Professor Richard McManus)

Chair: Anthony De Soyza
Declared a conflict, remained in the teleconference: Lucy Chappell, Julia Brown, Marian Knight, Kamal Mahtani
Declared a conflict and left the call: Andrew Farmer
Recommendation: Proceed to Funding Committee

20/90 HTA Researcher-led call Primary Research

NIHR133171 - Midwifery-led antenatal virtual maternal journaling - improving women’s postnatal mental health (Professor Debra Bick)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

20/89 HTA Researcher-led call Evidence Synthesis

NIHR133755 - “Hearable” technologies for reluctant hearing aid users (Dr Saima Rajasingam)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

20/90 HTA Researcher-led call Primary Research

NIHR133854 - High-throughput genome optical mapping for the diagnosis of structural variants and repeat expansions in neurogenetic diseases (Dr Andrea Cortese)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

20/90 HTA Researcher-led call Primary Research

NIHR133306 - Safety and acceptability of Duodenal Mucosal ReSurfacing (DMRS) Using Hybrid Argon Plasma Coagulation (HAPC) System for the Treatment of Type 2 Diabetes (T2D) (Dr Sudarshan Kadri)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit and Uncompetitive

20/90 HTA Researcher-led call Primary Research

NIHR133793 - StratCare 2: Pragmatic multi-site randomised controlled trial of stratified psychological treatment for depression (Dr Jaime Delgadillo)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

20/90 HTA Researcher-led call Primary Research

NIHR133605 - Cervical screening after menopause (CeSAMe) study (Ms Clare Gilham)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

20/90 HTA Researcher-led call Primary Research

NIHR133747 - Prognostic and diagnostic value of Cardiac Computed Tomography in Aortic Stenosis – a multi-centre study (Dr Tarun Mittal)

Chair: Lucy Chappell
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: Andrew Farmer
Recommendation: Out of Remit

20/90 HTA Researcher-led call Primary Research

NIHR133799 - Determining the role of Endothelin in Microcirculatory Function in Myocardial Ischaemia (Professor Michael Fisher)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

20/90 HTA Researcher-led call Primary Research

NIHR133549 - Improving estimates of premorbid cognitive ability (Professor Peter Bright)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

20/90 HTA Researcher-led call Primary Research

NIHR133780 - Efficacy of minimally invasive verteporfin photodynamic therapy to induce tumour cell death in breast cancer (Professor Jayant Vaidya)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

20/90 HTA Researcher-led call Primary Research

NIHR133828 - Development of a Portable and Autonomous Imaging Device To Improve Cardiovascular Disease Detection Using Retinal Vascular Function (PORTAL) (Mr Hassan Ejaz)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

20/90 HTA Researcher-led call Primary Research

NIHR133631 - PRESERVED Memory: Personalised Risk Evaluation through Supported and Enhanced Risk factor management to prevent Vascular Event-related Decline in Memory (Professor Phyo Myint)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Kamal Mahtani
Declared a conflict and left the call: None declared
Recommendation: Out of Remit

20/90 HTA Researcher-led call Primary Research

NIHR133027 - The clinical effectiveness and cost effectiveness of Structured Psychological Support for people with a diagnosis of personality disorder: Randomised controlled trial. (Professor Mike Crawford)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: Lucy Chappell, Kamal Mahtani, Marian Knight
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

20/90 HTA Researcher-led call Primary Research

NIHR133787 - Randomised trial of Suction for Primary Pneumothorax Early Resolution (Dr Rob Hallifax)

Chair: Julia Brown
Declared a conflict, remained in the teleconference: Lucy Chapell, Kamal Mahtani, Marian Knight
Declared a conflict and left the call: Andrew Farmer
Recommendation: Proceed to Funding Committee

20/28 Repair and rehabilitation of hand flexor tendon injury

NIHR133582 - Prospective randomised controlled trial comparing three splints for finger flexor tendon repairs (FIRST study) (Mrs Emma Bamford)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

20/89 HTA Researcher-led call Evidence Synthesis

NIHR133834 - Palliative treatment of jaundice in people with malignant distal biliary obstruction: a systematic review of randomised controlled trials, network meta-analysis, and cost-effectiveness analysis (Professor Kurinchi Gurusamy)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

20/90 HTA Researcher-led call Primary Research

NIHR133056 - Sugammadex for preventIoN oF pOst-operative pulmoNary complIcAtions (SINFONIA) (Dr Jon Silversides)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee

20/90 HTA Researcher-led call Primary Research

NIHR133371 - Impact of early reoperation and extent of resection in molecularly-subtyped low-grade gliomas – a phase III, prospective, randomized, controlled trial (The EREBIO Trial) (Mr George Samandouras)

Chair: Andrew Farmer
Declared a conflict, remained in the teleconference: None declared
Declared a conflict and left the call: None declared
Recommendation: Proceed to Funding Committee