Meeting
HTA Funding Committee (Clinical Evaluation and Trials)
Minutes of the March 2022 Meeting
Day 1 – Tuesday 8th March 2022
Venue
Danubius Hotel, Regents Park
Present Members
- Professor Olivia Wu (Chair)
- Professor Rakesh Heer (Deputy Chair)
- Professor Andrew Farmer (HTA Programme Director)
- Dr Jennifer Bostock (Public Committee member)
- Dr Kate Brown
- Dr Elizabeth Camacho
- Professor Charlotte Coles
- Professor Alun Davies
- Mrs Hannah de Merode (Public Committee member)
- Professor Jon Dorling
- Dr Francesca Fiorentino
- Associate Professor Paul French
- Dr Katie Gillies
- Professor Daniel Hind
- Professor Sally Hopewell
- Dr Pamela Jacobsen (Trainee Committee member)
- Associate Professor Rebecca Kearney
- Professor Gavin Perkins
- Professor Thomas Pinkney
- Professor Jonathan Rees
- Dr Nigel Rees
- Dr Gurdeep Sagoo
- Professor Kapil Sayal
- Dr Elizabeth Warburton
- Professor James Wason
- Professor David Weller
HTA Secretariat
- Dr Nick Hicks (Consultant Advisor)
- Mrs Karen Williams (Senior Research Manager)
- Dr Brogan Ashley (Research Manager)
- Miss Hebe Sims (Assistant Research Manager)
Apologies
- Dr Elena Pizzo
- Ms Joanne Haviland
Quoracy Information
Voting members: 27 (Emergency Quoracy = 14 = 50%)
Voting members present on Day 1: (100%)
Stage 2 Proposals
21/511 HTA Researcher-led call Primary Research
Chair: Olivia Wu
Conflicts: Daniel Hind, Thomas Pinkney, Nigel Rees, Gavin Perkins, Jennifer Bostock
NIHR150364 - Prehospital Recognition and Antibiotics for emergency patients with Sepsis: evaluation of safety, costs and effectiveness (PhRASe 2) (Jenna Jones)
Decision: Resubmission at Stage 1
21/511 HTA Researcher-led call Primary Research
Chair: Olivia Wu
Conflicts: None
NIHR150600 - The United Kingdom Arm of the Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery (TRICS IV) Trial: An international, multi-centre, randomized trial to assess the clinical and cost-effectiveness of liberal transfusion thresholds in younger patients undergoing cardiac surgery. (Gavin Murphy)
Decision: Programme Oversight Committee to consider fund with changes
21/511 HTA Researcher-led call Primary Research
Chair: Andrew Farmer
Conflicts: Katie Gillies, Elizabeth Camacho, Thomas Pinkney, Rakesh Heer, Jon Dorling, Olivia Wu, David Weller
NIHR150664 - DOes early gdM diagnosis Improve pregNancy Outcomes (DOMINO)? (Rebecca Reynolds)
Decision: Decline
21/511 HTA Researcher-led call Primary Research
Chair: Rakesh Heer
Conflicts: Rebecca Kearney, Jonathan Rees, Bethan Woods, Sally Hopewell, Jennifer Bostock
NIHR150195 - Surgery compared with sling immobilisation in the management of adults with a displaced unstable fracture of the distal clavicle: a multi-centre, non-inferiority, randomised controlled trial (DIDACT – DIsplaced DistAl Clavicle Trial) (Harvinder Pal Singh)
Decision: Programme Oversight Committee to consider fund with changes
21/504 Amiodarone vs beta blockade for new onset atrial fibrillation in adult intensive care
Chair: Olivia Wu
Conflicts: Katherine Brown, Rebecca Kearney, Thomas Pinkney, Nigel Rees, Andrew Farmer, Gavin Perkins
NIHR150027 - A randomised controlled trial to investigate clinical and cost effectiveness of Amiodarone vs Beta Blockade for new onset atrial fibRillation in icU - a Pragmatic sTudy (ABBRUPT) (Tony Whitehouse)
Decision: Programme Oversight Committee to consider fund with changes
21/504 Amiodarone vs beta blockade for new onset atrial fibrillation in adult intensive care
Chair: Olivia Wu
Conflicts: Katherine Brown, Thomas Pinkney, Rebecca Kearney, Nigel Rees, Andrew Farmer, Gavin Perkins
NIHR150481 - Atrial fibrillation management with Beta Blockade versus Amiodarone (ABBA): a randomised controlled trial (Peter Watkinson)
Decision: Decline
Stage 1 Proposals
21/556 NIHR NICE Rolling Call (HTA Programme: Sep 21 - Jan 22)
Chair: Olivia Wu
Conflicts: Thomas Pinkney
NIHR150396 - The 7Cs Study: recognition and Care of Chronic kidney disease after Cancer or Critical Care using Cystatin C (John Prowle)
Decision: Decline
21/556 NIHR NICE Rolling Call (HTA Programme: Sep 21 - Jan 22)
Chair: Olivia Wu
Conflicts: Rakesh Heer, Thomas Pinkney, Katie Gillies, Gurdeep Sagoo
NIHR151246 - Randomised Evaluation of Stent Insertion after uncomplicated endourological Stone Treatment (RESIST) (Veeru Kasivisvanathan)
Decision: Resubmission at Stage 1
21/556 NIHR NICE Rolling Call (HTA Programme: Sep 21 - Jan 22)
Chair: Rakesh Heer
Conflicts: Andrew Farmer, Jonathan Rees, Thomas Pinkney, Rebecca Kearney, Gavin Perkins, Sally Hopewell
NIHR150983 - INITIATE: INCREASED MOBILITY IN HOSPITAL AFTER HIP FRACTURE (Rebecca Kearney)
Decision: Shortlist
21/554 Health Technology Assessment Programme Researcher-led (primary research)
Chair: Olivia Wu
Conflicts: James Wason, Pamela Jackson
NIHR151099 - ACORN: A multi-site randomised COntrolled trial to evaluate the impact of a group tReatment for aNtenatal anxiety (Heather O'Mahen)
Decision: Resubmission at Stage 1
21/554 Health Technology Assessment Programme Researcher-led (primary research)
Chair: Rakesh Heer
Conflicts: Olivia Wu
Left the meeting: Alun Davies, Kate Brown
NIHR151794 - DIrect oral anticoagulant Safety and efficacy: a randomised trial of the Optimal management of Left VEntricular thrombus (DISOLVE) (Divaka Perera)
Decision: Decline
21/554 Health Technology Assessment Programme Researcher-led (primary research)
Chair: Olivia Wu
Conflicts: Thomas Pinkney, Rebecca Kearney, Gavin Perkins, Gurdeep Sagoo
NIHR151203 - Functional Assessment for Surgery by Timed Walk (FAST-Walk) study. (Tom Abbott)
Decision: Decline
Day 2 - Wednesday 9th March 2022
Venue
Danubius Hotel, Regents Park
Present Members
- Professor Olivia Wu (Chair)
- Professor Rakesh Heer (Deputy Chair)
- Professor Andrew Farmer (HTA Programme Director)
- Dr Jennifer Bostock (Public Committee member)
- Dr Kate Brown
- Dr Elizabeth Camacho
- Professor Charlotte Coles
- Professor Alun Davies
- Mrs Hannah de Merode (Public Committee member)
- Professor Jon Dorling
- Dr Francesca Fiorentino
- Associate Professor Paul French
- Dr Katie Gillies
- Professor Daniel Hind
- Professor Sally Hopewell
- Dr Pamela Jacobsen (Trainee Committee member)
- Associate Professor Rebecca Kearney
- Professor Gavin Perkins
- Professor Thomas Pinkney
- Professor Jonathan Rees
- Dr Nigel Rees
- Dr Gurdeep Sagoo
- Professor Kapil Sayal
- Dr Elizabeth Warburton
- Professor James Wason
- Professor David Weller
Secretariat
- Dr Nick Hicks (Consultant Advisor)
- Mrs Karen Williams (Senior Research Manager)
- Dr Brogan Ashley (Research Manager)
- Miss Hebe Sims (Assistant Research Manager)
Apologies
- Dr Elena Pizzo
- Ms Joanne Haviland
Quoracy Information
Voting members: 27 (Emergency Quoracy = 14 = 50%)
Voting members present on Day 2: (100%)
Stage 1 Proposals
21/554 Health Technology Assessment Programme Researcher-led (primary research)
Chair: Olivia Wu
Conflicts: Rakesh Heer, Gurdeep Sagoo, James Wason
NIHR151883 - Optimum therapy for thromboembolic complications after mitral valve repair-The PROTECT MVR Trial (Enoch Akowuah)
Decision: Shortlist
21/554 Health Technology Assessment Programme Researcher-led (primary research)
Chair: Rakesh Heer
Conflicts: Rebecca Kearney, Elizabeth Camacho, Katie Gillies, Andrew Farmer, Gavin Perkins
NIHR151372 - HEAL-D (Healthy Eating & Active Lifestyles for Diabetes): a multicentre, randomised controlled trial comparing effectiveness and cost-effectiveness of culturally-tailored versus standard diabetes self-management support programmes in Black-African and Black-Caribbean adults with type 2 diabetes (Louise Goff)
Decision: Shortlist
21/554 Health Technology Assessment Programme Researcher-led (primary research)
Chair: Rakesh Heer
Conflicts: Andrew Farmer, Thomas Pinkney, Gavin Perkins, Elizabeth Warburton, Jennifer Bostock, David Weller
NIHR151530 - Early versus Later AntiPlatelet uSE after Chronic Subdural Haematoma (ELAPSE-CSDH) (Paul Brennan)
Decision: Decline
21/554 Health Technology Assessment Programme Researcher-led (primary research)
Chair: Andrew Farmer
Conflicts: Olivia Wu, Rakesh Heer, Katherine Brown, Thomas Pinkney, Gavin Perkins, Katie Gillies, Alun Davies
NIHR151601 - Glucocorticoids in Adults With Acute Respiratory Distress Syndrome: Randomised Clinical Trial (GuARDS Trial) (Manu Shankar-Hari)
Decision: Shortlist
21/554 Health Technology Assessment Programme Researcher-led (primary research)
Chair: Andrew Farmer
Conflicts: Olivia Wu, Rakesh Heer, Alun Davies, Thomas Pinkney, Elizabeth Warburton, Katie Gillies, Francesca Fiorentino
NIHR151846 - COMeT – Carotid endarterectomy vs Optimal Medical Therapy (Matthew Bown)
Decision: Shortlist
21/554 Health Technology Assessment Programme Researcher-led (primary research)
Chair: Rakesh Heer
Conflicts: Katherine Brown, Thomas Pinkney, Gavin Perkins, Elizabeth Warburton
NIHR151716 - Randomised Trial of Early Cranioplasty (RETELL) (Adel Helmy)
Decision: Decline
21/554 Health Technology Assessment Programme Researcher-led (primary research)
Chair: Olivia Wu
Conflicts: Thomas Pinkney, Gurdeep Sagoo, James Wason, Jennifer Bostock
NIHR151863 - The Healing of ExcisionAl wounds on Lower legs by Secondary intention (HEALS) 2 (David Veitch)
Decision: Shortlist
21/554 Health Technology Assessment Programme Researcher-led (primary research)
Chair: Olivia Wu
Conflicts: Rebecca Kearney, Gavin Perkins, Elizabeth Camacho, Francesca Fiorentino, Nigel Rees
NIHR151533 - Neurally adjusted ventilatory assist in the adult critical care unit: A randomized, parallel group, allocation concealed, controlled, open, phase 3 pragmatic clinical and cost effectiveness trial with internal pilot (Daniel Hadfield)
Decision: Decline
21/554 Health Technology Assessment Programme Researcher-led (primary research)
Chair: Rakesh Heer
Conflicts: Andrew Farmer, Charlotte Coles, Katie Gillies
NIHR151760 - Adjuvant radiotherapy in patients with high-risk primary cutaneous Squamous Cell Carcinoma AFTER surgery (SCC-AFTER): an open label, multicentre, two-arm phase III randomised trial (Agata Rembielak)
Decision: Shortlist
21/554 Health Technology Assessment Programme Researcher-led (primary research)
Chair: Olivia Wu
Conflicts: Andrew Farmer
Left the meeting: Gurdeep Sagoo
NIHR151415 - Is Motivational Enhancement Therapy clinically effective and cost effective in improving adherence to continuous positive airway pressure in people with Obstructive Sleep Apnoea Hypopnoea Syndrome? (Julia Kelly)
Decision: Shortlist
21/554 Health Technology Assessment Programme Researcher-led (primary research)
Chair: Rakesh Heer
Conflicts: Katie Gillies
NIHR151753 - EValuatIng DiurEtics in Normal CarE (EVIDENCE): - a cluster randomised study of prescribing policy for thiazide-like drugs used for primary hypertension (Alexander Doney)
Decision: Decline
21/554 Health Technology Assessment Programme Researcher-led (primary research)
Chair: Olivia Wu
Conflicts: Thomas Pinkney, Katie Gillies
Arrived at meeting: Gurdeep Sagoo
NIHR151933 - SARveillance: an international, randomised controlled trial with additional patient-preference arms of high versus lower intensity radiological surveillance following resection of primary retroperitoneal, abdominal and pelvic soft tissue sarcoma (Samuel Ford)
Decision: Decline