Day 1 - 7th March 2023
Venue
Danubius Hotel, Regents Park, London
Present Members
- Olivia Wu (Chair)
- Rakesh Heer (Deputy Chair)
- Andrew Farmer (Programme Director)
- Elizabeth Camacho
- Hannah de Merode (Public Committee Member)
- Jon Dorling
- Francesca Fiorentino
- Paul French
- Katie Gillies
- Joanne Haviland
- Daniel Hind
- Gavin Perkins
- Thomas Pinkney
- Elena Pizzo
- Jonathan Rees
- Nigel Rees
- Gurdeep Sagoo
- Kapil Sayal
- Elizabeth Warburton
- James Wason
- David Weller
- Claudia Cooper
- Munyaradzi Dimairo
- Edward Wilson
- James Glasbey (Committee Member Development Scheme Participant)
- Janet Deane
- Jennifer Bostock (Public Committee Member)
- Nicholas Hicks
- Bethan Woods
Secretariat
- Nick Hicks (Consultant Advisor)
- Karen Williams (Senior Research Manager)
- Brogan Ashley (Research Manager)
- Hebe Sims (Assistant Research Manager)
Apologies
- Alun Davies
- Sam Creavin
- Sheona St Hilaire
Observers
- None
Quoracy Information
Voting members: 31 (Emergency Quoracy = 16 = 50%)
Voting members present on Day 1: 25 (80%)
Stage 2 applications
22/1 HTA Researcher-led call Primary Research
NIHR152686 - The ELIPSE Study - a randomised controlled trial comparing the clinical and cost-effectiveness of lymph node removal in patients undergoing curative surgery for localised high-risk prostate cancer. (Krishna Narahari)
Chair: Olivia Wu
Conflicts: Thomas Pinkney, Elena Pizzo, Rakesh Heer, Katie Gillies
Decision: Programme Oversight Committee to consider fund with changes
22/1 HTA Researcher-led call Primary Research
NIHR152151 - Prothrombin complex concentrate versus fresh frozen plasma for bleeding in adults undergoing heart surgery (PROPHESY-2 trial). (Laura Green)
Chair: Rakesh Heer
Conflicts: Olivia Wu, Gavin Perkins, Joanne Haviland, Claudia Cooper, Andrew Farmer
Decision: Programme Oversight Committee to consider fund with changes
22/1 HTA Researcher-led call Primary Research
NIHR153216 - DEXACELL: Dexamethasone as an adjunctive therapy for the management of cellulitis - a randomised controlled trial in urgent secondary care (Edward Carlton)
Chair: Olivia Wu
Conflicts: Andrew Farmer, Gavin Perkins, Edward Wilson, Jennifer Bostock
Decision: Programme Oversight Committee to consider fund with changes
22/1 HTA Researcher-led call Primary Research
NIHR152208 - STEPFORWARD: A randomised controlled trial of the clinical and cost-effectiveness of a hydraulic self-aligning ankle-foot for patients with a below-knee amputation categorised as having "limited community mobility" (Natalie Vanicek)
Chair: Rakesh Heer
Conflicts: Bethan Woods, Munyaradzi Dimairo
Decision: Decline
22/61 HTA Researcher-led call Primary Research
NIHR153742 - EXamining antibiotics for ulCerated skIn cancer Surgical Excision (EXCISE): a pragmatic, multi-arm 'durations' design randomised controlled trial. (Rachel Abbott)
Chair: Olivia Wu
Conflicts: Katie Gillies, Andrew Farmer, Jennifer Bostock
Decision: Decline
22/61 HTA Researcher-led call Primary Research
NIHR153760 - Quitting Using E-cigarettes before Surgery Trial (QUEST) (Ian Pope)
Chair: Olivia Wu
Conflicts: Edward Wilson, Bethan Woods, Andrew Farmer, Thomas Pinkney, David Weller, James Glasbey, Jennifer Bostock
Decision: Decline
22/61 HTA Researcher-led call Primary Research
NIHR155123 - A multicentre randomised trial of surgical versus percutaneous revascularisation of ischaemic left ventricular dysfunction in the United Kingdom, with embedded internal pilot and health economic analysis (BCIS4) (Gavin Murphy)
Chair: Rakesh Heer
Conflicts: James Wason, Olivia Wu
Decision: Straight Fund
22/61 HTA Researcher-led call Primary Research
NIHR154131 - Adjunctive Local Drug Treatment at the Time Of Endoscopic Surgery for Primary and Recurrent Bulbar Urethral Stricture in Men (PReBUS) (Nadir Osman)
Chair: Olivia Wu
Conflicts: Daniel Hind, Nigel Rees, Munyaradzi Dimairo, Bethan Woods, Rakesh Heer
Decision: Decline
22/61 HTA Researcher-led call Primary Research
NIHR153808 - A Phase III randomised control clinical trial of radiotherapy with radiosensitisation versus intravesicular Bacillus Calmette-Guerin therapy for high-risk non-muscle invasive bladder cancer - TRAIN (Ananya Choudhury)
Chair: Olivia Wu
Conflicts: Elizabeth Camacho, Joanne Haviland, Gurdeep Sagoo, Rakesh Heer, Janet Deane
Decision: Decline
22/61 HTA Researcher-led call Primary Research
NIHR155054 - A Randomised Multiple Centre Trial of Conservative versus Liberal Fluid Administration for Children Receiving a Kidney Transplant (LIMITS) (Wesley Hayes)
Chair: Olivia Wu
Conflicts: Andrew Farmer, Munyaradzi Dimairo
Decision: Decline
22/61 HTA Researcher-led call Primary Research
NIHR154915 - Fix Or Replace Enhancing distal humeruS fracTure outcomes (FOREST) (Ben Ollivere)
Chair: Olivia Wu
Conflicts: Elizabeth Camacho, Jon Dorling, Jonathan Rees, Kapil Sayal, David Weller
Decision: Programme Oversight Committee to consider fund with changes
22/44 Innovative ventilation technologies for treatment of patients in ICU (HTA)
NIHR153743 - Weaning ventilated children in the paediatric intensive care unit (PICU) with Neurally Adjusted Ventilatory Assist (NAVA) versus standard care: a pragmatic randomised controlled trial with a cost consequences evaluation (Reinout Mildner)
Chair: Rakesh Heer
Conflicts: Gavin Perkins, Thomas Pinkney, James Glasbey
Decision: Decline
22/44 Innovative ventilation technologies for treatment of patients in ICU (HTA)
NIHR154796 - Awake prone positioning in patients with acute hypoxaemic respiratory failure not due to COVID-19: a multi-centre, pragmatic, allocation concealed, individual patient randomised, parallel group, open-label clinical trial (AWAKE-PRONE) (Keith Couper)
Chair: Andrew Farmer
Conflicts: Gavin Perkins, Nigel Rees, Gurdeep Sagoo, James Wason, Thomas Pinkney, Rakesh Heer, James Glasbey, Olivia Wu
Decision: Programme Oversight Committee to consider fund with changes
Day 2 - 8th March 2023
Venue
Danubius Hotel, Regents Park, London
Present Members
- Olivia Wu (Chair)
- Rakesh Heer (Deputy Chair)
- Andrew Farmer (Programme Director)
- Elizabeth Camacho
- Hannah de Merode (Public Committee Member)
- Alun Davies
- Jon Dorling
- Francesca Fiorentino
- Paul French
- Katie Gillies
- Joanne Haviland
- Daniel Hind
- Gavin Perkins
- Thomas Pinkney
- Elena Pizzo
- Jonathan Rees
- Nigel Rees
- Gurdeep Sagoo
- Kapil Sayal
- James Wason
- David Weller
- Claudia Cooper
- Munyaradzi Dimairo
- Edward Wilson
- James Glasbey (Committee Member Development Scheme Participant)
- Janet Deane
- Jennifer Bostock (Public Committee Member)
- Nicholas Hicks
- Bethan Woods
Secretariat
- Nick Hicks (Consultant Advisor)
- Steph Garfield-Birkbeck (Head of the HTA Programme Secretariat)
- Karen Williams (Senior Research Manager)
- Brogan Ashley (Research Manager)
- Hebe Sims (Assistant Research Manager)
Apologies
- Sam Creavin
- Sheona St Hilaire
- Elizabeth Warburton
Observers
- None
Quoracy Information
Voting members: 31 (Emergency Quoracy = 16 = 50%)
Voting members present on Day 2: 25 (80 %)
22/44 Innovative ventilation technologies for treatment of patients in ICU (HTA)
NIHR154501 - Airway Pressure Release Ventilation (APRV) vs conventional ventilation for patients with moderate to severe acute hypoxemic respiratory failure (RELEASE) (Luigi Camporota)
Chair: Olivia Wu
Conflicts: Francesca Fiorentino, Katie Gillies, Gavin Perkins, Nigel Rees, David Weller
Decision: Programme Oversight Committee to consider fund with changes
22/44 Innovative ventilation technologies for treatment of patients in ICU (HTA)
NIHR154892 - Airway Pressure Release Ventilation (APRV) versus Prone Positioning in Severe Acute Respiratory Distress Syndrome (ARDS) Acronym: PROACTIVE: PROning vs APRV: Clinical Trial of Impact on VEntilation (Callum Kaye)
Chair: Olivia Wu
Conflicts: Katie Gillies, Gavin Perkins, Jonathan Rees, Rakesh Heer, Jennifer Bostock, Thomas Pinkney, Munyaradzi Dimairo, James Glasbey
Decision: Decline
22/44 Innovative ventilation technologies for treatment of patients in ICU (HTA)
NIHR155119 - Neurally adjusted ventilatory assist in the adult critical care unit: A randomized, parallel group, allocation concealed, controlled, open, phase 3 pragmatic clinical and cost effectiveness trial with internal pilot (Daniel Hadfield)
Chair: Rakesh Heer
Conflicts: Francesca Fiorentino, Gavin Perkins, Edward Wilson, Katie Gillies
Decision: Programme Oversight Committee to consider fund with changes
22/44 Innovative ventilation technologies for treatment of patients in ICU (HTA)
NIHR154798 - Innovative ventilation technologies in adults and children: an evidence synthesis to inform clinical practice and future research priorities (Keith Couper)
Chair: Olivia Wu
Conflicts: Katie Gillies, Gavin Perkins, Nigel Rees, James Glasbey
Decision: Programme Oversight Committee to consider fund with changes
Stage 1 Applications
22/112 HTA Researcher-led call Primary Research
NIHR156590 - Palin Stammering Therapy for School Aged Children (Palin STSC(8-14)): A randomised controlled trial comparing a new intervention for children who stammer aged 8-14 with usual treatment (Sharon Millard)
Chair: Olivia Wu
Conflicts: Edward Wilson
Left the meeting: Daniel Hind
Decision: Decline
22/112 HTA Researcher-led call Primary Research
NIHR156782 - A randomised controlled trial, with an embedded process evaluation, assessing the effectiveness and cost-effectiveness of an exercise-based, lifestyle intervention aiming to support adult patients with venous leg ulcers (REACTIVE-LU). (Markos Klonizakis)
Chair: Olivia Wu
Conflicts: Munyaradzi Dimairo, Edward Wilson, Dan Hind
Decision: Decline
22/112 HTA Researcher-led call Primary Research
NIHR157107 - Stroke prophylaxis with Apixaban in Chronic Kidney Disease stage 5 patients with Atrial fibrillation (Fergus Caskey)
Chair: Andrew Farmer
Conflicts room: Katie Gillies, Olivia Wu
Left the meeting: Rakesh Heer
Decision: Shortlist
22/112 HTA Researcher-led call Primary Research
NIHR156450 - Eye movement desensitisation and reprocessing therapy (EMDR) for patients with depression in primary care: a randomised controlled trial (Nicola Wiles)
Chair: Olivia Wu
Conflicts: Elizabeth Camacho, Katie Gillies, Claudia Cooper, Jennifer Bostock, Andrew Farmer
Decision: Decline
22/112 HTA Researcher-led call Primary Research
NIHR156318 - Surgery or embolisATIoN for bleeding haemorrhoids (SATIN) (Clare Bent)
Chair: Andrew Farmer
Conflicts: Elizabeth Camacho, Bethan Woods, Daniel Hind, Munyaradzi Dimairo
Decision: Decline
22/112 HTA Researcher-led call Primary Research
NIHR157427 - Treatment of >400µ centre-involving Diabetic macular oedema with Anti-VEGF monotherapy versus combined Anti-VEGF and subthreshold Micropulse lasEr (SML) applied when central retinal thickness is reduced below 400µ (DAME): A pragmatic randomised equivalence trial (Noemi Lois)
Chair: Olivia Wu
Conflicts: None
Decision: Shortlist
22/112 HTA Researcher-led call Primary Research
NIHR157478 - Antibiotics for acute lower respiratory tract infection in older people (Mark Lown)
Chair: Olivia Wu
Conflicts: Katie Gillies, Edward Wilson, Jennifer Bostock, Janet Deane
Left the meeting: Steph Garfield-Birkbeck
Decision: Shortlist
22/115 NIHR James Lind Alliance Priority Setting Partnerships Rolling Call (HTA Programme: Sept 22 - Jan 23)
NIHR155875 - Timing Of Nutrition In emergenCy laparotomy (TONIC) - A randomised trial comparing early parenteral nutrition vs standard nutritional care following emergency laparotomy. (Matthew Lee)
Chair: Olivia Wu
Conflicts: Katie Gillies, Daniel Hind, Thomas Pinkney, Munyaradzi Dimairo
Decision: Shortlist
22/114 NIHR NICE Rolling Call (HTA Programme: Sept 22 - Jan 23)
NIHR156500 - Are advanced airway protection, secretions removal and cuff pressure maintenance systems effective for mechanically ventilated patients on intensive care? (Gareth Kitchen)
Chair: Andrew Farmer
Conflicts: Olivia Wu, Katie Gillies, Gavin Perkins, Nigel Rees, Thomas Pinkney, Janet Deane, James Glasbey
Arrived at the meeting: Steph Garfield-Birkbeck
Decision: Shortlist
22/114 NIHR NICE Rolling Call (HTA Programme: Sept 22 - Jan 23)
NIHR157097 - Big Toe OstEoarthritis (Big TOE) Trial (Michael Backhouse)
Chair: Olivia Wu
Conflicts: Jon Dorling, Jonathan Rees, Gavin Perkins
Decision: Shortlist