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Home > About us > Document library > HTA Funding Committee Public Minutes 5-6 March 2024

HTA Funding Committee Public Minutes 5-6 March 2024

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Published: 23 May 2024

Version: 1

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Meeting

HTA Funding Committee CET March 2024

Day 1: 5 March 2024

Venue 

Danubius Hotel, Regents Park, London

Present Members

Olivia Wu (Chair)
Rakesh Heer (Deputy Chair)
Andrew Farmer (HTA Programme Director)
Edward Carlton
Jennifer Bostock (Public Committee Member)
James Glasbey (Committee Member Development Scheme Participant)
Paul French
Daniel Hind
Bethan Woods
Claudia Cooper
Elizabeth Warburton
Joanne Haviland
Munyaradzi Dimairo
Edward Wilson
Edward Roddy
Augusto Azuara-Blanco
Janet Deane
James Wason
Nigel Rees
Jonathan Rees
Hannah de Merode (Public Committee Member)
Jon Dorling
Gurdeep Sagoo
Sheona St Hilaire (Public Committee Member)
Sarah Walker
Rebecca Spencer (Committee Member Development Scheme Participant)

Secretariat

Nicholas Hicks
Elena Harden
Daniel Housego
Sara Rayhan
Gill Watson

Apologies

Stamatina Iliodromiti
David Weller
Alun Davies
Francesca Fiorentino
Natasha Campling (Committee Member Development Scheme Participant)

Observers

Clare Eyres (Senior Research Manager)
Alexandra Lawrence

Quoracy Information

  • Voting members: 29
  • Quorum = 19 = 66%
  • Emergency Quorum = 14 = 50%
  • Voting members present on Day 1: 25

Stage 2 Applications

23/65 HTA NICE Rolling Call

NIHR160810 - Randomised controlled trial of the clinical and cost effectiveness of supervised pelvic floor muscle training plus vaginal pessary compared to supervised pelvic floor muscle training alone for management of pelvic organ prolapse

  • Chair: Olivia Wu
  • Declared a conflict and left the room:  Rakesh Heer, Augusto Azuara-Blanco
  • Decision: Programme Oversight Committee to consider fund with changes

23/63 HTA Researcher-led call Primary Research

NIHR161891 - COMBAT: Clinical- and cost-effectiveness, safety and acceptability of COMBined phacovitrectomy, versus sequentiAl viTrectomy and cataract surgery, for the management of rhegmatogenous retinal detachment: A Randomised Equivalence Clinical Trial.

  • Chair: Olivia Wu
  • Declared a conflict and left the room:  Edward Roddy, Augusto Azuara-Blanco, Gurdeep Sagoo, Jon Dorling
  • Decision: Programme Oversight Committee to consider fund with changes

NIHR161731 - The 4th Multicentre Intrapleural Sepsis Trial (MIST4) - a definitive randomised clinical effectiveness study comparing initial video assisted thoracic surgery and intrapleural enzyme therapy in adult patients with pleural infection.

  • Chair: Rakesh Heer
  • Declared a conflict and left the room:  Edward Carlton, Paul French, Andrew Farmer, Jennifer Bostock
  • Decision: Programme Oversight Committee to consider fund with changes

NIHR160872 - EXamining antibiotics for ulCerated skIn cancer Surgical Excision (EXCISE)

  • Chair: Rakesh Heer
  • Declared a conflict and left the room:  Jennifer Bostock, Andrew Farmer, Gurdeep Sagoo, Sarah Walker
  • Decision: Programme Oversight Committee to consider fund with changes

NIHR160252 - optimum therapy for those with Atrial Fibrillation aFtEr Completing miTral valve repair surgery - The AFFECT trial (Enoch Akowuah)

  • Chair: Andrew Farmer
  • Declared a conflict and left the room:  Olivia Wu, Munyaradzi Dimairo, Rakesh Heer, James Wason, Gurdeep Sagoo
  • Decision: Programme Oversight Committee to consider fund with changes

NIHR160459 - Combination chemotherapy versus Bacillus Calmette-Guérin (BCG) for high-risk non-muscle invasive bladder cancer– a phase III multi-centre randomised controlled trial (COBRA)

  • Chair: Olivia Wu
  • Declared a conflict and left the room:  Daniel Hind, Joanne Haviland, Munyaradzi Dimairo, Rakesh Heer, James Wason, Gurdeep Sagoo, Augusto Azuara-Blanco
  • Decision: Programme Oversight Committee to consider fund with changes

NIHR161994 - TOPical Glycopeptides vs Usual antibiotics in Neck of femur (TOPGUN) trial

  • Chair: Olivia Wu
  • Declared a conflict and left the room:  Jennifer Bostock, Daniel Hind, Claudia Cooper, Joanne Haviland, Edward Roddy, Jonathan Rees, Rakesh Heer
  • Decision: Decline

23/65 HTA NICE Rolling Call

NIHR161925 - Prospective Randomized Evaluation of Emerging Novel Treatments for Infection prophylaxis in Total Joint Replacement (PREVENT-iT)

  • Chair: Olivia Wu
  • Declared a conflict and left the room:  Rakesh Heer, James Wason, Jonathan Rees, Gurdeep Sagoo, Augusto Azuara-Blanco
  • Decision: Decline

23/4 HTA James Lind Alliance Priority Setting Partnerships Rolling Call

NIHR158400 - TADPOLE: A multicentre, pragmatic, phase III randomised controlled trial comparing Targeted Axillary Dissection vs axillary node clearance in patients with POsitive axillary Lymph nodes in Early breast cancer

  • Chair: Olivia Wu
  • Declared a conflict and left the room:  Edward Carlton, Daniel Hind, Joanne Haviland, Andrew Farmer, Augusto Azuara-Blanco, Gurdeep Sagoo
  • Decision: Programme Oversight Committee to consider fund with changes

23/66 HTA James Lind Alliance Priority Setting Partnerships Rolling Call

NIHR161215 - Carotid endarterectomy vs Medical Therapy (COMET) for people with recently symptomatic carotid artery stenosis: A randomised controlled non-inferiority trial.

  • Chair: Andrew Farmer
  • Declared a conflict and left the room:  Elizabeth Warburton, Olivia Wu, Rakesh Heer, Jonathan Rees, Augusto Azuara-Blanco, Jennifer Bostock
  • Decision:  Decline

Stage 1 Applications

23/106 The use of HPV self-sampling within cervical screening programme - HTA Commissioned Call 

NIHR163530 - YouChoose: self-sampling or routine cervical screening?

  • Chair: Olivia Wu
  • Declared a conflict and left the room:  Claudia Cooper, Joanne Haviland, Rakesh Heer, Gurdeep Sagoo
  • Arrived at the meeting: Alexandra Lawrence, NSC
  • Decision: Decline Return to POC

Day 2: 6 March 2024

Venue 

Danubius Hotel, Regents Park, London

Present Members

Olivia Wu (Chair)
Rakesh Heer (Deputy Chair)
Edward Carlton
Jennifer Bostock (Public Committee Member)
James Glasbey (Committee Member Development Scheme Participant)
Paul French
Daniel Hind
Bethan Woods
Claudia Cooper
Elizabeth Warburton
Joanne Haviland
Munyaradzi Dimairo
Edward Wilson
Edward Roddy
Augusto Azuara-Blanco
Francesca Fiorentino
James Wason
Nigel Rees
Jonathan Rees
Hannah de Merode (Public Committee Member)
Jon Dorling
Gurdeep Sagoo
Sheona St Hilaire (Public Committee Member)
Sarah Walker
Rebecca Spencer (Committee Member Development Scheme Participant)

Secretariat

Nicholas Hicks
Elena Harden
Daniel Housego
Sara Rayhan
Gill Watson

Apologies

Andrew Farmer (HTA Programme Director)
Stamatina Iliodromiti
David Weller
Alun Davies
Janet Deane
Natasha Campling (Committee Member Development Scheme Participant)

Observers

Clare Eyres (Senior Research Manager)

Quoracy Information

  • Voting members: 29
  • Quorum = 19 = 66%
  • Emergency Quorum = 14 = 50%
  • Voting members present on Day 2: 25

HTA Commissioned Calls

23/107 Nerve blocks for reducing pain after knee replacement

  • Chair: Gurdeep Sagoo
  • Declared a conflict and left the room:  Daniel Hind, Bethan Woods, Olivia Wu, Edward Roddy, Jon Dorling, Edward Carlton, Jennifer Bostock, James Glasbey, Paul French, Munyaradzi Dimairo, Rakesh Heer, Jonathan Rees, Sarah Walker
  • Arrived at the meeting: Francesca Fiorentino

NIHR161369 - Pain relief using nerve blocks for elective primary knee replacement surgery (PREfER)

  • Decision: Decline

NIHR162215 - Clinical and cost-effectiveness of adductor canal nerve blocks for reducing pain after knee replacement: The ACORN randomised trial

  • Decision: Decline

NIHR163261 - nerve Block for Chronic Pain After Knee Replacement Surgery (the BACPAKS trial): A multi-centre, randomised, placebo-controlled trial to evaluate the clinical and cost effectiveness of adding an adductor canal block to standard perioperative approaches in primary elective knee joint replacement

  • Decision: Shortlist

NIHR163413 - Comparison of Adductor canal block and Genicular nerve block for Analgesia for Total Knee replacement under General Anaesthesia

  • Decision: Decline

NIHR163501 - Regional Anaesthesia in Addition to Local Infiltration to Support Enhanced Outcomes after Knee Replacement (REALISE): A randomised controlled, double blind, placebo-controlled trial of adductor canal block versus placebo for pain control after knee replacement surgery.

  • Decision: Shortlist

NIHR163689 - Pain Assessment Study after Total knee Arthroplasty (PASTA)

  • Decision: Decline

NIHR165928 - Do motor sparing nerve blocks improve pain and mobilisation compared to local anaesthetic infiltration in primary knee arthroplasty?

  • Decision: Decline

NIHR165934 - Adductor Canal Blockade for Prevention of Chronic and Acute Pain afterTotal Knee Arthroplasty, A Randomised Controlled Trial

  • Decision: Decline

23/104 Treatment for illicit benzodiazepine dependence in adults enrolled in an opioid substitution programme

NIHR163461 - An RCT of a tailored intervention to reduce street benzodiazepine use with diazepam maintenance versus standard care of tapered diazepam in adults receiving OAT. (the In-BOAT trial)

  • Chair: Olivia Wu
  • Declared a conflict and left the room:  Rakesh Heer, Augusto Azuara-Blanco
  • Decision: Shortlist

23/108 Treatment attenuation in acute myeloid leukaemia

NIHR164255 - EVOLVE: EValuating efficacy of treatment attenuation compared with standard treatment in OLder acute myeloid leukaemia (AML) patients undergoing VEnetoclax-based frontline therapy

  • Chair: Olivia Wu
  • Declared a conflict and left the room:  Jonathan Rees
  • Decision: Decline Return to POC

23/105 Management of toddler’s fractures in children

  • Chair: Olivia Wu
  • Declared a conflict and left the room:  Edward Carlton, Daniel Hind, Jonathan Rees, Bethan Woods, Paul French, Munyaradzi Dimairo, Augusto Azuara-Blanco, Nigel Rees

NIHR163203 - The TWIST Study: Treatment With or Without Immobilisation Study in Toddler's fracture. A multi-centre prospective randomised non inferiority trial of immobilisation versus non- immobilisation for the treatment of Toddler's fracture in children.

  • Decision: Shortlist

NIHR165783 - Treatment of Toddlers Fractures: Observation Or Immobilisation (TOTs)

  • Decision: Shortlist

23/113 - NIHR James Lind Alliance Priority Setting Partnerships Rolling Call

NIHR163879 - Big Toe OstEoarthritis (BigTOE) Injections

  • Chair: Rakesh Heer
  • Declared a conflict and left the room:  Edward Roddy, Jon Dorling, Gurdeep Sagoo
  • Decision: Decline

NIHR164094 - The effect of early REvasculariSation on diabeTic fOot ulceR hEaling; a randomised controlled trial - RESTORE

  • Chair: Olivia Wu
  • Declared a conflict and left the room:  Francesca Fiorentino, Rakesh Heer, Jonathan Rees
  • Decision: Shortlist

23/110 - HTA Researcher-led call Primary Research Call

NIHR163892 - A multicentre, single blind, randomised trial to assess the clinical and cost-effectiveness of Intracapsular versus extraCAPsular Tonsillectomy for REcurrent Acute Tonsillitis in children (ICAPTREAT)

  • Chair: Olivia Wu
  • Declared a conflict and left the room:  Rakesh Heer, Augusto Azuara-Blanco, James Wason, Gurdeep Sagoo
  • Decision: Decline

NIHR163288 - STAYING well and active: clinical and cost-effectiveness of personalised community-based behavioural ACTIvation to promote Vitality and wEll-being in mild dementia (STAYING ACTIVE)

  • Chair: Olivia Wu
  • Declared a conflict and left the room:  Claudia Cooper
  • Decision: Decline

NIHR163518 - Promoting recovery after hip fracture through a patient-carer training programme (HIP HELPER)

  • Chair: Rakesh Heer
  • Declared a conflict and left the room:  Jennifer Bostock, Edward Roddy, Jonathan Rees, Jon Dorling, Gurdeep Sagoo
  • Decision: Decline

NIHR162920 - What is the clinical and cost-effectiveness of Prophylactic Oral meDIcations Used for episodic and chronic Migraine? (PODIUM)

  • Chair: Rakesh Heer
  • Declared a conflict and left the room:  Edward Roddy, Jon Dorling, Gurdeep Sagoo, Nigel Rees
  • Decision: Decline

NIHR163351 - A Phase III randomised control clinical trial of radiotherapy with radiosensitisation versus intravesical Bacillus Calmette-Guerin therapy for high-risk non-muscle invasive bladder cancer - TRAIN

  • Chair: Olivia Wu
  • Declared a conflict and left the room:  Joanne Haviland
  • Left the meeting: Rakesh Heer
  • Decision: Shortlist

NIHR164402 - Step-wedge cluster design randomised controlled trial of Open vs Robotic Gastrectomy for gastric AdeNocarcinoma (ORGAN)

  • Chair: Olivia Wu
  • Declared a conflict and left the room:  Jennifer Bostock, Daniel Hind, Francesca Fiorentino, Edward Roddy, Jonathan Rees
  • Decision: Decline

NIHR165070 - ADMET: ADJUVANT CAVITY RADIATION VS ACTIVE SURVEILLANCE FOR RESECTED BRAIN METASTASES

  • Chair: Olivia Wu
  • Declared a conflict and left the room: None.
  • Decision: Decline