Meeting
HTA Funding Committee (Clinical Evaluations and Trials)
Day 1 - Tuesday 5th July 2022
Venue
Virtual via Microsoft Teams
Present Members
- Olivia Wu (Chair)
- Rakesh Heer (Deputy Chair)
- Andrew Farmer (HTA Programme Director)
- Katherine Brown
- Jennifer Bostock (Public Committee Member)
- Elizabeth Camacho
- Charlotte Coles
- Claudia Cooper
- Sam Creavin
- Alun Davies
- Hannah de Merode (Public Committee Member)
- Munyaradzi Dimairo
- Jon Dorling
- Francesca Fiorentino
- Paul French
- Katie Gillies
- Daniel Hind
- Sally Hopewell
- Pamela Jacobsen (Committee Member Development Scheme Participant)
- Rebecca Kearney
- Jonathan Rees
- Gurdeep Sagoo
- Kapil Sayal
- James Wason
- David Weller
Secretariat
- Nick Hicks (Consultant Advisor)
- Steph Garfield-Birkbeck (Head of the HTA Programme Secretariat)
- Karen Williams (Senior Research Manager)
- Brogan Ashley (Research Manager)
- Hebe Sims (Assistant Research Manager)
- Debbie Carter (Administrator)
Apologies
- Nigel Rees
- Joanne Haviland
- Thomas Pinkney
- Elena Pizzo
- Gavin Perkins
- Elizabeth Warburton
Observers
- Esther Mukuka
- Rosie Lovett
- Janet Messer
- James Morris
Quoracy Information
Voting members: 31 (Emergency Quoracy = 16 = 50%)
Voting members present on Day 1: 26 (84 %)
Stage 2 Applications
21/554 HTA Researcher-led call Primary Research
NIHR151415 - Is Motivational Enhancement Therapy clinically effective and cost effective in improving adherence to continuous positive airway pressure in people with Obstructive Sleep Apnoea Hypopnoea Syndrome? A randomised controlled trial. (Julia Kelly)
Chair: Olivia Wu
Conflicts: Andrew Farmer
Decision: Decline
21/554 HTA Researcher-led call Primary Research
NIHR151883 - Optimum therapy for thromboembolic complications after mitral valve repair-The PROTECT MVR Trial (Enoch Akowuah)
Chair: Olivia Wu
Conflicts: Rakesh Heer, Gurdeep Sagoo, James Wason, Munya Dimairo
Decision: Decline
21/554 HTA Researcher-led call Primary Research
NIHR151372 - HEAL-D (Healthy Eating & Active Lifestyles for Diabetes): a multicentre, pragmatic randomised controlled trial comparing effectiveness and cost-effectiveness of culturally tailored versus standard diabetes self-management programmes in Black-African and Black-Caribbean adults with type 2 diabetes (Louise Goff)
Chair: Rakesh Heer
Conflicts: Jennifer Bostock, Elizabeth Camacho, Andrew Farmer, Katie Gillies, Rebecca Kearney
Decision: Programme Oversight Committee to consider fund with changes
21/554 HTA Researcher-led call Primary Research
NIHR151846 - COMeT – Carotid endarterectomy vs Optimal Medical Therapy (Matthew Bown)
Chair: Andrew Farmer
Conflicts: Olivia Wu, Alun Davies, Katie Gillies, Francesca Fiorentino, Rakesh Heer
Decision: Decline
21/554 HTA Researcher-led call Primary Research
NIHR151601 - Glucocorticoids in Adults With Acute Respiratory Distress Syndrome: Randomised Clinical Trial (GuARDS Trial) (Manu Shankar-Hari)
Chair: Charlotte Coles
Conflicts: Andrew Farmer, Olivia Wu, Katherine Brown, Rakesh Heer, Alun Davies
Decision: Programme Oversight Committee to consider fund with changes
21/554 HTA Researcher-led call Primary Research
NIHR151863 - Secondary intention wound healing following excision of keratinocyte cancers on the lower legs: HEALS2 (David Veitch)
Chair: Olivia Wu
Conflicts: Gurdeep Sagoo, Jennifer Bostock, James Wason
Arrived/Left the meeting: Steph Garfield-Beck left the meeting
Decision: Programme Oversight Committee to consider fund with changes
21/554 HTA Researcher-led call Primary Research
NIHR151760 - Adjuvant radiotherapy in patients with high-risk primary cutaneous Squamous Cell Carcinoma AFTER surgery (SCC-AFTER): an open label, multicentre, two-arm phase III randomised trial (Agata Rembielak)
Chair: Rakesh Heer
Conflicts: Andrew Farmer, Katie Gillies, Rebecca Kearney, Charlotte Coles, Sam Creavin
Arrived/Left the meeting: James Morris left the meeting. Daniel Hind arrived at the meeting
Decision: Programme Oversight Committee to consider fund with changes
21/556 NICE Rolling Call
NIHR150983 - INITIATE: INCREASED MOBILITY IN HOSPITAL AFTER HIP FRACTURE (Rebecca Kearney)
Chair: Rakesh Heer
Conflicts: Sally Hopewell, Andrew Farmer, Jennifer Bostock, Rebecca Kearney, Jonathan Rees, Sam Creavin
Decision: Programme Oversight Committee to consider fund with changes
21/503 Peer-led harm reduction for problem substance use among people who are homeless
NIHR150358 - Effectiveness and cost-effectiveness of a peer-delivered, relational, harm reduction intervention to improve mental health, quality of life, and related outcomes, for people experiencing homelessness and substance use problems: The ‘SHARPS’ cluster randomised controlled trial. (Tessa Parkes)
Chair: Andrew Farmer
Conflicts: Olivia Wu, Katie Gillies, David Weller, Rakesh Heer
Decision: Programme Oversight Committee to consider fund with changes
Stage 1 Applications
21/556 NIHR NICE Rolling Call
NIHR151246 - Randomised Evaluation of Stent Insertion after uncomplicated endourological Stone Treatment (RESIST) (Veeru Kasivisvanathan)
Chair: Olivia Wu
Conflicts: Katie Gillies, Gurdeep Sagoo, Rakesh Heer
Decision: Decline
21/511 HTA Researcher-led call Primary Research
NIHR150364 - Prehospital Recognition and Antibiotics for emergency patients with Sepsis: evaluation of safety, costs and effectiveness (PhRASe 2) (Jenna Jones)
Chair: Rakesh Heer
Conflicts: Jennifer Bostock, Daniel Hind, Munyaradzi Dimairo
Arrived/Left the meeting: Rebecca Kearney left the meeting.
Decision: Shortlist
21/511 HTA Researcher-led call Primary Research
NIHR151099 - ACORN: A multi-site randomised COntrolled trial to evaluate the impact of a group tReatment for aNtenatal anxiety (Heather O'Mahen)
Chair: Olivia Wu
Conflicts: Elizabeth Camacho, Pamela Jacobsen, Kapil Sayal, James Wason, Rakesh Heer
Decision: Shortlist
22/1 HTA Researcher-led call Primary Research
NIHR153445 - Cholecystectomy As Secondary Prevention following ERCP – The CASPER Trial (Giles Toogood)
Chair: Olivia Wu
Conflicts: Daniel Hind, Jonathan Rees, Gurdeep Sagoo, Sam Creavin
Decision: Decline
22/1 HTA Researcher-led call Primary Research
NIHR152151 - Prothrombin complex concentrates versus fresh frozen plasma in adult patients who are undergoing heart surgery (PROPHESY-2 trial). (Laura Green)
Chair: Olivia Wu
Conflicts: Andrew Farmer, Alun Davies, Rakesh Heer
Arrived/Left the meeting: Jonathan Rees left the meeting.
Decision: Resubmission at stage 1
22/1 HTA Researcher-led call Primary Research
NIHR152506 - Restart tICrH: A Randomised Trial of Timing to Restart Direct Oral Anticoagulants after Traumatic Intracranial Haemorrhage (Catherine McMahon)
Chair: Rakesh Heer
Conflicts: Andrew Farmer, Katie Gillies
Arrived/Left the meeting: Alun Davies and Paul French left the meeting
Decision: Shortlist
22/1 HTA Researcher-led call Primary Research
NIHR152752 - TULIP2: A Randomised Controlled Trial of Surgical versus Non-Surgical Treatment of Lateral Compression Injuries of the Pelvis with Complete Sacral Fractures. (Mehool Acharya)
Chair: Olivia Wu
Conflicts: Jennifer Bostock, Andrew Farmer, Sally Hopewell, Rebecca Kearney, Jonathan Rees, Sam Creavin
Arrived/Left the meeting: Katie Gillies, Claudia Cooper, Janet Messer and Hannah de Merode left the meeting.
Decision: Decline
Day 2 - Wednesday 6th July 2022
Venue
Virtual via Microsoft Teams
Present Members
- Olivia Wu (Chair)
- Rakesh Heer (Deputy Chair)
- Andrew Farmer (HTA Programme Director)
- Katherine Brown
- Jennifer Bostock (Public Committee Member)
- Elizabeth Camacho
- Charlotte Coles
- Claudia Cooper
- Sam Creavin
- Alun Davies
- Hannah de Merode (Public Committee Member)
- Munyaradzi Dimairo
- Jon Dorling
- Francesca Fiorentino
- Paul French
- Katie Gillies
- Daniel Hind
- Sally Hopewell
- Pamela Jacobsen (Committee Member Development Scheme Participant)
- Rebecca Kearney
- Jonathan Rees
- Gurdeep Sagoo
- Kapil Sayal
- James Wason
Secretariat
- Nick Hicks (Consultant Advisor)
- Steph Garfield-Birkbeck (Head of the HTA Programme Secretariat)
- Karen Williams (Senior Research Manager)
- Brogan Ashley (Research Manager)
- Hebe Sims (Assistant Research Manager)
- Debbie Carter (Administrator)
Apologies
- Nigel Rees
- Joanne Haviland
- Thomas Pinkney
- Elena Pizzo
- Gavin Perkins
- David Weller
- Elizabeth Warburton
Observers
- Kate Greenwood
Quoracy Information
Voting members: 31 (Emergency Quoracy = 16 = 50%)
Voting members present on Day 2: 25 (81 %)
Stage 1 Applications
21/598 Health and social care outcomes and cost-effectiveness of assistive technologies
NIHR152466 - Evaluating the clinical and cost effectiveness of an intervention designed to optimise the home living environment of older people after discharge from hospital to maintain independence and health (Elizabeth Graham)
Chair: Olivia Wu
Conflicts: Jennifer Bostock, Katie Gillies, Gurdeep Sagoo
Decision: Decline
21/598 Health and social care outcomes and cost-effectiveness of assistive technologies
NIHR152941 - Mapping and evidence synthesis for assistive technologies to support adults living at home with long-term continence or toilet-use problems (Catherine Murphy)
Chair: Rakesh Heer
Conflicts: None Advised
Decision: Shortlist
22/1 HTA Researcher-led call Primary Research
NIHR153068 - Randomised trial of Pleural Symphysis Techniques for Primary Pneumothorax Recurrence Prevention (RAPPER) (Rob Hallifax)
Chair: Rakesh Heer
Conflicts: Andrew Farmer, Gurdeep Sagoo, Sally Hopewell
Arrived/Left the meeting: Jason Horsley left the meeting. Steph Garfield-Beck joined the meeting.
Decision: Decline
22/1 HTA Researcher-led call Primary Research
NIHR153131 - Antidepressants to prevent relapse in depression in older people (ANTLER 75+ Trial) (Robert Howard)
Chair: Olivia Wu
Conflicts: Jennifer Bostock, Elizabeth Camacho, Paul French, Andrew Farmer, Claudia Cooper, Rakesh Heer
Decision: Shortlist
22/1 HTA Researcher-led call Primary Research
NIHR153216 - DEXACELL: Dexamethasone as an adjunctive therapy for the management of cellulitis - a randomised controlled trial in urgent secondary care (Edward Carlton)
Chair: Olivia Wu
Conflicts: Andrew Farmer, Jennifer Bostock, Rebecca Kearney, Sam Creavin
Decision: Resubmission at Stage 1
22/1 HTA Researcher-led call Primary Research
NIHR152208 - STEPFORWARD: A mixed-methods randomised controlled trial of the clinical and cost-effectiveness of a hydraulic self-aligning ankle-foot for patients with a below-knee amputation categorised as having "limited community mobility" (Natalie Vanicek)
Chair: Rakesh Heer
Conflicts: Daniel Hind, Elizabeth Warburton
Decision: Resubmission at Stage 1
22/1 HTA Researcher-led call Primary Research
NIHR152252 - SHorter vs Longer CoUrse AnTibiotics – an AdaptivE BaYEsian Design Study (SHUTEYE) (Tony Whitehouse)
Chair: Rakesh Heer
Conflicts: Jon Dorling, Rebecca Kearney
Decision: Shortlist
22/1 HTA Researcher-led call Primary Research
NIHR152478 - Analgesic Effectiveness and safety of ibuprofen for patients undergoing elective major Gut Surgery (AEGIS) Trial (Caroline Thomas)
Chair: Olivia Wu
Conflicts: Daniel Hind, Katie Gillies, James Wason, Rakesh Heer
Decision: Decline
22/1 HTA Researcher-led call Primary Research
NIHR152686 - The ELIPSE Study - a randomised controlled trial comparing the clinical and cost-effectiveness of lymph node removal in patients undergoing curative surgery for localised high-risk prostate cancer. (Krishna Narahari)
Chair: Olivia Wu
Conflicts: Katie Gillies, Daniel Hind, Gurdeep Sagoo, James Wason, Rakesh Heer
Decision: Shortlist
22/1 HTA Researcher-led call Primary Research
NIHR152648 - A randomised controlled trial to evaluate the clinical and cost effectiveness of omitting the use of surgical drains in patients having mastectomy and/or axillary clearance for breast cancer: The Diamond Study (Shelley Potter)
Chair: Olivia Wu
Conflicts: Elizabeth Camacho, Katie Gillies, Rebecca Kearney, Charlotte Coles, Sam Creavin
Decision: Decline
22/1 HTA Researcher-led call Primary Research
NIHR152733 - Empirical oral AntibioticS for possible UTI in well appearing Young febrile infants (EASY). (Thomas Waterfield)
Chair: Rakesh Heer
Conflicts: Jon Dorling, Katherine Brown
Decision: Shortlist
22/1 HTA Researcher-led call Primary Research
NIHR153091 - A Blinded, Randomised Control Trial to Assess the Urinary Function at 3 months after Retzius-Sparing, Robotic-Assisted Radical Prostatectomy (Mathias Winkler)
Chair: Olivia Wu
Conflicts: Alun Davies, Katie Gillies, Francesca Fiorentino, Rakesh Heer
Decision: Decline
22/1 HTA Researcher-led call Primary Research
NIHR153437 - Randomised controlled trial of real time remote symptom monitoring using ASYMS during chemotherapy for older People Living with Cancer: CAREFOR study (Paul Ross)
Chair: Olivia Wu
Conflicts: Daniel Hind, Elizabeth Camacho
Decision: Decline