Day 1 - 31 October 2023
Venue
Microsoft Teams
Present Members
- Olivia Wu (Chair)
- Rakesh Heer (Deputy Chair)
- Andrew Farmer (Programme Director)
- Jennifer Bostock (Public Committee Member)
- James Glasbey (Committee Member Development Scheme Participant)
- Alun Davies
- Paul French
- Daniel Hind
- Kapil Sayal
- Bethan Woods
- Claudia Cooper
- Elizabeth Warburton
- Joanne Haviland
- Munyaradzi Dimairo
- Francesca Fiorentino
- Edward Wilson
- Augusto Azuara-Blanco
- Elizabeth Camacho
- Janet Deane
- James Wason
- Katie Gillies
- David Weller
- Nigel Rees
- Jonathan Rees
- Hannah de Merode (Public Committee Member)
- Jon Dorling
- Gurdeep Sagoo
- Sheona St Hilaire (Public Committee Member)
Secretariat
- Nick Hicks
- Helen Payne
- Anna Cutler
- Karen Williams
- Brogan Ashley
- Hebe Sims
- Gill Watson
Apologies
- Stamatina Iliodromiti
- Elena Pizzo
- Alun Davies
Observers
- Rebecca Spencer
- Maria Hassard
Quoracy Information
- Voting members: 28
- Quorum = 17 = 66%
- Emergency Quorum = 14 = 50%
- Voting members present on Day 1: 26
Stage 2 Applications
23/1 HTA Researcher-led call Primary Research
NIHR158902 - Getting Recovery Right After Neck Dissection for Head and Neck Cancer (GRRAND)
Chair: Olivia Wu
Conflicts: Nigel Rees, Jonathan Rees, Andrew Farmer
Arrived at the meeting: Rebecca Spencer
Left the meeting: Helen Payne, Alun Davies
Decision: Programme Oversight Committee to consider fund with changes
NIHR159585 - Requirement fOr Surgery after ERCP (ROSE)
Chair: Rakesh Heer
Conflicts: Katie Gillies, Jonathan Rees, Gurdeep Sagoo
Decision: Programme Oversight Committee to consider fund with changes
NIHR157800 – FAST-Forward Boost: A randomised clinical trial testing a 1-week course of curative simultaneous integrated boost radiotherapy against a standard 3-week schedule in patients with early breast cancer
Chair: Olivia Wu
Conflicts: Joanne Haviland, Edward Wilson, Elizabeth Camacho, Katie Gillies, Bethan Woods
Arrived at the meeting: Alun Davies
Decision: Programme Oversight Committee to consider fund with changes
NIHR159595 – ProstatEctomy Surgery In low-volume DissEminated prostate cancer in addition to Neo-adjuvant systemic therapy +/- radioTherapy: a randomised controlled trial (PRESIDENT)
Chair: Olivia Wu
Conflicts: Rakesh Heer, Jonathan Rees, Andrew Farmer, Katie Gillies
Decision: Decline
NIHR158678 - CLArithromycin for Stroke associated Pneumonia (CLASP): A prospective, randomised open-label blinded-endpoint (PROBE) phase 3 multicentre trial
Chair: Rakesh Heer
Conflicts: Munyaradzi Dimairo, Elizabeth Camacho, James Wason, Olivia Wu, Elizabeth Warburton, Janet Deane
Decision: Programme Oversight Committee to consider fund with changes
23/4 NIHR James Lind Alliance Priority Setting Partnerships Rolling Call Stage 2 Application
NIHR158400 - TADPOLE: A multicentre, pragmatic, phase III randomised controlled trial comparing Targeted Axillary Dissection vs axillary node clearance in patients with POsitive axillary Lymph nodes in Early breast cancer
Chair: Olivia Wu
Conflicts: Daniel Hind, Joanne Haviland, Elizabeth Camacho, Katie Gillies, Gurdeep Sagoo, Andrew Farmer
Left the meeting: Alun Davies
Decision: Resubmission as a stage 2
Stage 1 Applications
23/63 HTA Research-led Stage 1 Applications
NIHR159798 - ASCEND 2: An early social communication intervention for young children with Down syndrome – a randomised controlled trial
Chair: Olivia Wu
Conflicts: None Advised
Arrived at the meeting: Sheona St. Hilaire
Left the meeting: Maria Hassard
Decision: Decline
NIHR160692 - A randomised multi-centre non-inferiority trial of incremental haemodialysis compared to conventional thrice weekly haemodialysis
Chair: Olivia Wu
Conflicts: Bethan Woods, Daniel Hind, Munyaradzi Dimairo
Decision: Decline
NIHR161346 - Clinical and cost-effectiveness of Learning Through Play plus Culturally adapted Cognitive Behaviour Therapy (LTP+CaCBT) for treating postnatal depression in British African and Caribbean women and improving their children’s wellbeing
Chair: Rakesh Heer
Conflicts: Jennifer Bostock, Elizabeth Camacho
Decision: Decline
NIHR162026 - LOTUS study comparing pre-operative magnetic resonance cholangiography+/-endoscopic retrograde cholangio-pancreatography+laparoscopic cholecystectomy against Laparoscopic intra-operative ultrasound+/-bile duct exploration+cholecystectomy" in patients with gallstones at high-risk of bile duct stones.
Chair: Rakesh Heer
Conflicts: Katie Gillies
Decision: Decline
NIHR161891 - COMBAT: Clinical- and cost-effectiveness, safety and acceptability of COMBined phacovitrectomy, versus sequentiAl viTrectomy and cataract surgery, for the management of rhegmatogenous retinal detachment: A Randomised Equivalence Clinical Trial.
Chair: Olivia Wu
Conflicts: Jon Dorling, Augusto Azuara-Blanco
Decision: Shortlist
NIHR161051 - SCS for Diabetic Peripheral Neuropathic Pain (DPNP); A Randomised Sham-Controlled Trial
Chair: Rakesh Heer
Conflicts: Munyaradzi Dimairo, Elizabeth Camacho, Daniel Hind, Olivia Wu
Decision: Decline
NIHR161731 - The 4th Multicentre Intrapleural Sepsis Trial (MIST4) - a definitive randomised clinical effectiveness study comparing initial video assisted thoracic surgery and intrapleural enzyme therapy in adult patients with pleural infection.
Chair: Olivia Wu
Conflicts: Jennifer Bostock, Paul French, Munyaradzi Dimairo, Andrew Farmer
Arrived at the meeting: Alun Davies
Decision: Shortlist
NIHR161968 - The effects of continuous glucose monitor use in adults with non-insulin treated type 2 diabetes mellitus: exploring frequency, dose and mode of use
Chair: Rakesh Heer
Conflicts: Munyaradzi Dimairo, Andrew Farmer
Decision: Decline
NIHR160872 - EXamining antibiotics for ulCerated skIn cancer Surgical Excision (EXCISE)
Chair: Olivia Wu
Conflicts: Jennifer Bostock, Katie Gillies
Left the meeting: Andrew Farmer
Decision: Shortlist
Day 2 - 1 November 2023
Venue
Microsoft Teams
Present Members
- Olivia Wu (Chair)
- Rakesh Heer (Deputy Chair)
- Andrew Farmer (Programme Director)
- Jennifer Bostock (Public Committee Member)
- James Glasbey (Committee Member Development Scheme Participant)
- Alun Davies
- Paul French
- Daniel Hind
- Kapil Sayal
- Bethan Woods
- Claudia Cooper
- Elizabeth Warburton
- Joanne Haviland
- Francesca Fiorentino
- Edward Wilson
- Stamatina Iliodromiti
- Augusto Azuara-Blanco
- Elizabeth Camacho
- Janet Deane
- Elena Pizzo
- James Wason
- Katie Gillies
- David Weller
- Nigel Rees
- Jonathan Rees
- Hannah de Merode (Public Committee Member)
- Jon Dorling
- Gurdeep Sagoo
- Sheona St Hilaire (Public Committee Member)
Secretariat
- Nicholas Hicks
- Helen Payne
- Karen Williams
- Brogan Ashley
- Hebe Sims
- Gill Watson
Apologies
- Munyaradzi Dimairo
Observers
- Rebecca Spencer
- Maria Hassard
Quoracy Information
- Voting members: 28
- Quorum = 17 = 66%
- Emergency Quorum = 14 = 50%
- Voting members present on Day 1: 28
Stage 1 Applications
23/63 Researcher-led applications continued
NIHR159367 - Bariatric surgery for the Reduction of cArdioVascular Events randomized controlled trial. (BRAVE)
Chair: Olivia Wu
Conflicts: James Glasbey, Francesca Fiorentino, Katie Gillies, Alun Davies, Daniel Hind, Rakesh Heer, Andrew Farmer
Decision: Decline
NIHR160252 - optimum therapy for those with Atrial Fibrillation aFtEr Completing miTral valve repair surgery - The AFFECT trial
Chair: Daniel Hind
Conflicts: Olivia Wu, Munyaradzi Dimairo, Elizabeth Camacho, James Wason, Gurdeep Sagoo, Rakesh Heer, Stamatina Iliodromiti
Decision: Shortlist
NIHR161870 - Neoadjuvant Chemotherapy and Transoral surgery versus transoral surgery and Adjuvant Radiotherapy and chemotherapy (NeCTAR) trial
Chair: Olivia Wu
Conflicts: Joanne Haviland, James Glasbey, Andrew Farmer
Decision: Decline
NIHR160459 - Combination chemotherapy versus Bacillus Calmette-Guérin (BCG) for high-risk non-muscle invasive bladder cancer– a phase III multi-centre randomised controlled trial (COBRA)
Chair: Olivia Wu
Conflicts: Joanne Haviland, Munyaradzi Dimairo, Francesca Fiorentino, Rakesh Heer, Augusto Azuara-Blanco, James Wason, Katie Gillies, Gurdeep Sagoo, Daniel Hind
Arrived at the meeting: Karen Williams
Left the meeting: Helen Payne
Decision: Shortlist
NIHR161994 - TOPical Glycopeptides vs Usual antibiotics in Neck of femur (TOPGUN) trial
Chair: Olivia Wu
Conflicts: Jennifer Bostock, Daniel Hind, Francesca Fiorentino, Claudia Cooper, Joanne Haviland
Decision: Shortlist
23/65 NIHR NICE Rolling Call Stage 1 Applications
NIHR161925 - Prospective Randomized Evaluation of Emerging Novel Treatments for Infection prophylaxis in Total Joint Replacement (PREVENT-iT)
Chair: Olivia Wu
Conflicts: Rakesh Heer, Augusto Azuara-Blanco, James Wason, Katie Gillies, Gurdeep Sagoo
Decision: Shortlist
NIHR161626 - Saline Nasal Irrigation For acute Sinusitis trial
Chair: Olivia Wu
Conflicts: Jennifer Bostock, Munyaradzi Dimairo, Andrew Farmer, Janet Deane
Decision: Decline
NIHR161866 - What is the optimal follow-up of adults with repaired or replaced heart valves?
Chair: Rakesh Heer
Conflicts: James Glasbey, Andrew Farmer, David Weller
Arrived at the meeting: Helen Payne
Left the meeting: Karen Williams
Decision: Decline
NIHR160810 - Randomised controlled trial of the clinical and cost effectiveness of supervised pelvic floor muscle training plus vaginal pessary compared to supervised pelvic floor muscle training alone for management of pelvic organ prolapse
Chair: Olivia Wu
Conflicts: Rakesh Heer, Augusto Azuara-Blanco, Katie Gillies
Arrived at the meeting: Jonathan Rees
Decision: Shortlist
23/66 NIHR James Lind Alliance Priority Setting Partnerships Rolling Call Stage 1 Applications
NIHR160618 - Varicose vEin SymPtom managemEnt via compRession-VESPER
Chair: Andrew Farmer
Conflicts: Jennifer Bostock, Olivia Wu, Francesca Fiorentino, Augusto Azuara-Blanco, Katie Gillies, Jonathan Rees, Rakesh Heer, Alun Davies
Decision: Decline
NIHR161215 - Carotid endarterectomy vs Medical Therapy (COMET) for people with recently symptomatic carotid artery stenosis: A randomised controlled non-inferiority trial.
Chair: Andrew Farmer
Conflicts: Jennifer Bostock, Elizabeth Warburton, Olivia Wu, Francesca Fiorentino, Augusto Azuara-Blanco, Katie Gillies, Jonathan Rees, Rakesh Heer, Alun Davies
Decision: Shortlist
NIHR161897 - The effectiveness and implementation of a walking exercise behaviour change intervention: A hybrid randomised controlled trial with health economic analysis (Motivating structured walking activity in intermittent claudication (MOSAIC2))
Chair: Olivia Wu
Conflicts: James Glasbey, Janet Deane
Left the meeting: Elizabeth Warburton
Decision: Decline