Tuesday 17 September2019 (Day 1)
Place: Danubius Hotel, London
Present members
- Professor Joy Adamson
- Professor Steven Brown
- Mr Paul Charlton
- Dr Emilio Fernandez-Egea
- Professor Saul Faust
- Professor Simon Gilbody (Deputy Chair)
- Professor Steve Goodacre (Chair)
- Professor Richard Grieve
- Dr Rebecca Harmston
- Professor Angela Hassiotis
- Mr Rakesh Heer
- Professor Catherine Hewitt
- Professor Pip Logan
- Professor Nick Maskell
- Mr Daniel Perry
- Professor Rebecca Reynolds
- Professor Chris Rogers
- Professor Jonathan Ross
- Professor Tracey Sach
- Professor Andrew Shennan (afternoon only)
- Professor Sobha Sivaprasad
- Professor Catrin Tudur-Smith
- Dr Katrina Turner
- Professor Hywel Williams (Programme Director)
- Professor Nefyn Williams
NETSCC, HTA Secretariat
- Dr Nick Hicks (Consultant Advisor)
- Ms Helen Payne (Senior Research Manager)
- Miss Connie Temple-Brown (Assistant Research Manager)
- Ms Kathy Tier (Research Manager)
- Mrs Karen Williams (Senior Research Manager)
- Miss Alessandra Wilkinson-Smith (Assistant Research Manager)
Apologies
- Professor Andrew Shennan (absent morning only)
- Professor Gary Collins
- Professor Jane Nixon
- Professor Greta Rait
- Mr David Symes
Observers
No observers
Quoracy Information
Voting members: 26 Quorum = 18
Voting members present on Day 1: 23 (88%)
Commissioning Stage 2 Proposals, shortlisted at May 2019 Committee
18/176: HTA Precision Medicine
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Professor Simon Gilbody
NIHR128636: Optimal diagnostic strategies for patients presenting in primary care with lower gastrointestinal symptoms: evidence synthesis and cost-effectiveness analysis
(Associate Professor Bethany Shinkins, University of Leeds)
Funding Committee recommendation: Decline Return to POC
18/186: Active management vs conservative management for symptomatic brain cavernoma
Chair: Professor Simon Gilbody
Declared a conflict and left the room: Professor Steven Brown, Professor Steve Goodacre, Professor Rebecca Reynolds, Professor Chris Rogers, Professor Catrin Tudur Smith, Dr Katrina Turner
NIHR128694: Cavernomas A Randomised Effectiveness (CARE) pilot trial, to address the effectiveness of active treatment (with neurosurgery or stereotactic radiosurgery) versus conservative management in people with symptomatic brain cavernoma
(Professor Rustam Salman, The University of Edinburgh)
Funding Committee recommendation: Invite stage 2 Resubmission (next funding committee meeting)
18/187: Relapsing polymyalgia rheumatica
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Dr Rebecca Harmston
NIHR129150: Methotrexate versus placebo for preventing relapse in polymyalgia rheumatica (MERLIN-PMR): a multi-centre, phase III, parallel-group randomised controlled trial.
(Dr Sarah Mackie, University of Leeds)
Funding Committee recommendation: Decline Return to POC
18/189: Combination treatment for dementia with Lewy Bodies and Parkinson's disease dementia
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Dr Emilio Fernandez-Egea, Dr Rebecca Harmston, Professor Angela Hassiotis, Professor Rebecca Reynolds, Professor Tracey Sach
NIHR129175: COmBining memantine And cholinesterase inhibitors in Lewy body dementia treatment Trial (COBALT)
(Professor John-Paul Taylor, Newcastle University)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
18/190: Blood pressure management in critically ill children
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Professor Richard Grieve, Professor Hywel Williams
NIHR128895: Evaluating the clinical and cost effectiveness of using a more permissive blood pressure target to guide careful titration of vasoactive agents in critically ill children with hypotension: PRotocolised Evaluation of permiSSive blood pressure targets versus Usual caRE (PRESSURE)
(Dr David Inwald, Imperial College Healthcare NHS Trust)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
18/192: Pulpotomy for the management of irreversible pulpitis in mature teeth
Chair: Professor Simon Gilbody
Declared a conflict and left the room: Professor Steve Goodacre, Professor Catherine Hewitt, Professor Nefyn Williams
NIHR129089: Pulpotomy vs Root canal trEatment for cariouS teEth with IRreVersiblE pulpitis (PRESERVE)
(Dr Ikhlas El karim, The Queen's University of Belfast)
Funding Committee recommendation: Decline
NIHR129230: Pulpotomy for the management of irreversible pulpitis in mature teeth (Pulpotomy for Irreversible Pulpitis - PIP Trial)
(Professor Janet Clarkson, University of Dundee)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
18/193: Laparoscopic hysterectomy
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Dr Rebecca Harmston, Professor Nick Maskell, Professor Jonathan Ross
Professor Andrew Shennan joined the meeting
NIHR128991: LAparoscopic Versus Abdominal hysterectomy (LAVA) trial
(Professor T Justin Clark, Birmingham Women's NHS Foundation Trust)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
18/195: Extended treatment in early intervention in psychosis services
Chair: Professor Simon Gilbody
Declared a conflict and left the room: Professor Steven Brown, Dr Emilio Fernandez-Egea, Professor Steve Goodacre, Professor Angela Hassiotis, Professor Jonathan Ross
NIHR129501: Extended treatment in early intervention in psychosis services.
(Dr Paul French, Pennine Care NHS Foundation Trust)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
18/197: Hysteroscopic removal of retained placenta
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Dr Rebecca Harmston, Professor Nick Maskell, Mr Daniel Perry, Professor Rebecca Reynolds, Professor Chris Rogers, Dr Katrina Turner
NIHR129561: The Hysteroscopic removAl of Retained Placenta (HARP) study
(Dr Islam Gamaleldin, University of Bristol)
Funding Committee recommendation: Decline Return to POC
18/198: Exercise therapy for the treatment of tendinopathies
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Professor Nick Maskell, Professor Chris Rogers, Dr Katrina Turner
NIHR128950: Exercise therapy for the treatment of tendinopathies: a synthesis of the evidence
(Mr Andrew Beswick, University of Bristol)
Funding Committee recommendation: Decline
NIHR129388: Exercise therapy for the treatment of tendinopathies: A mixed methods evidence synthesis
(Professor Kay Cooper, Robert Gordon University)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
Wednesday 18th September 2019 (Day 2)
Place: Danubius Hotel, London
Present members
- Professor Steven Brown
- Mr Paul Charlton
- Dr Emilio Fernandez-Egea
- Professor Saul Faust
- Professor Simon Gilbody (Deputy Chair)
- Professor Steve Goodacre (Chair)
- Professor Richard Grieve
- Professor Angela Hassiotis
- Professor Catherine Hewitt
- Professor Nick Maskell
- Mr Daniel Perry
- Professor Rebecca Reynolds
- Professor Chris Rogers
- Professor Jonathan Ross
- Professor Tracey Sach
- Professor Andrew Shennan (morning only)
- Professor Sobha Sivaprasad
- Professor Catrin Tudur-Smith
- Professor Hywel Williams (Programme Director)
- Professor Nefyn Williams
NETSCC, HTA Secretariat
- Dr Nick Hicks (Consultant Advisor)
- Ms Kathy Tier (Research Manager)
- Miss Alessandra Wilkinson-Smith (Assistant Research Manager)
- Mrs Karen Williams (Senior Research Manager)
Apologies
- Professor Joy Adamson
- Professor Gary Collins
- Dr Rebecca Harmston
- Professor Rakesh HeerP
- rofessor Pip Logan
- Professor Jane Nixon
- Professor Greta Rait
- Professor Andrew Shennan (afternoon only)
- Mr David Symes
- Dr Katrina Turner
Observers
No observers
Quoracy Information
Voting members: 18 Quorum = 18
Voting members present on Day 2: 18 (67%)
Commissioning Stage 1 proposals – received from July call close
19/31: Gastrointestinal side effects in cancer immune checkpoint therapy
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Professor Saul Faust, Professor Tracey Sach, Professor Hywel Williams
NIHR129948: ARTISTIX: A randomised trial of intravenous steroid therapy +/- infliximab for gastrointestinal side effects in cancer immune checkpoint therapy
(Dr Matthew Wheater, University Hospital Southampton NHS Foundation Trust)
Funding Committee recommendation: Shortlist
19/32: Behavioural intervention to treat anxiety in adults with autism and moderate to severe learning disabilities
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Professor Angela Hassiotis, Professor Chris Rogers
NIHR129839: Addressing anxiety in autistic adults with moderate to severe intellectual disability: an intervention development study.
(Professor Jacqueline Rodgers, University of Newcastle upon Tyne)
Funding Committee recommendation: Decline
NIHR129804: Behavioural interventions to treat anxiety in adults with autism and moderate to severe intellectual disabilities (BEAMS – ID)
(Professor Peter Langdon, University of Warwick)
Funding Committee recommendation: Shortlist
19/33: Treating specific phobias in children with moderate to severe learning disabilities
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Professor Angela Hassiotis, Professor Catherine Hewitt, Professor Hywel Williams
NIHR130308: Treating specific phobias in children with moderate to severe learning disabilities
(Professor Barry Wright, University of York)
Funding Committee recommendation: Shortlist
NIHR130177: Specific phobias in children with learning disabilities (SPIRIT): An adaptation and feasibility study
(Professor Kylie Gray, University of Warwick)
Funding Committee recommendation: Shortlist
19/34: Medication for ADHD in adults with a history of psychosis or bipolar disorder
Chair: Professor Simon Gilbody
Declared a conflict and left the room: no conflicts declared
NIHR129817: The clinical and cost-effectiveness of Stimulant compared with Non-stimulant medication for adults with Attention-deficit / hyperactivity disorder and a history of Psychosis or biPolar disordER: SNAPPER
(Professor Steven Marwaha, University of Birmingham)
Funding Committee recommendation: Shortlist
19/36: Antioxidant supplements to slow AMD progression
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Professor Saul Faust, Professor Angela Hassiotis, Professor Catherine Hewitt, Professor Rebecca Reynolds, Professor Chris Rogers, Professor Sobha Sivaprasad
NIHR129653: A Randomised Controlled Trial of Antioxidants to Slow Progression of Age-Related Macular Degeneration (the AEON Study)
(Dr Praveen Patel, Moorfields Eye Hospital NHS Foundation Trust)
Funding Committee recommendation: Decline Return to POC
NIHR130108: Prevention of late age-related macular degeneration using anitoxidant supplementation (PAMDAS) study.
(Dr Ruth Hogg, The Queen's University of Belfast)
Funding Committee recommendation: Decline Return to POC
19/37: Deep infiltrating endometriosis
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Professor Rebecca Reynolds, Professor Chris Rogers, Professor Hywel Williams
NIHR130310: Deep infiltrating endometriosis: management by medical treatment versus early surgery: DIAMOND
(Professor Kevin Cooper, NHS Grampian)
Funding Committee recommendation: Shortlist
19/38: Scanning confocal ophthalmoscopy for diabetic eye screening
Chair: Professor Simon Gilbody
Declared a conflict and left the room: Professor Sobha Sivaprasad
NIHR129647: Scanning confocal ophthalmoscopy for diabetic eye screening
(Professor Peter Scanlon, Gloucestershire Hospitals NHS Foundation Trust)
Funding Committee recommendation: Shortlist
19/39: Minimally invasive operative interventions for bladder outlet obstruction due to benign prostatic hyperplasia
Chair: Professor Simon Gilbody
Declared a conflict and left the room: Professor Steve Goodacre, Professor Chris Rogers
NIHR129747: A randomised trial of minimally invasive treatments for bladder outlet obstruction due to enlarged prostate in the National Health Service using a network of treating centres.
Acronym: OPTIONS Trial
Options for Prostate Treatment Innovation Or Normal Surgery
(Dr Tobias Page, The Newcastle Upon Tyne Hospitals NHS Foundation Trust)
Funding Committee recommendation: Shortlist
19/40: Needle and syringe exchange schemes and opiate substitution therapy in the UK
Chair: Professor Steve Goodacre
Declared a conflict and left the room: Professor Richard Grieve, Professor Chris Rogers
NIHR129726: Enhancing access to needle and syringe programmes and opioid substitution therapy for under-served populations of people who inject drugs: Developing a programme theory through qualitative and realist review methods.
(Dr Magdalena Harris, London School of Hygiene & Tropical Medicine)
Funding Committee recommendation: Decline
NIHR129798: Title: Understanding the contextual factors that impact on the effective provision of opiate substitution therapy (OST) and needle and syringe programmes (NSP) in the UK: a multi-method study and realist evaluation of what works, for whom and under what circumstances
(Dr Alison Munro, University of Dundee)
Funding Committee recommendation: Shortlist
NIHR130004: ENGAGE - A realist evaluation of the combined effectiveness of needle and syringe provision and opioid substitution therapy programmes for people who inject drugs
(Professor Vivian Hope, Liverpool John Moores University)
Funding Committee recommendation: Shortlist
19/11: HTA Researcher-led call Primary Research
Chair: Professor Steve Goodacre
Declared a conflict and left the room: no conflicts declared
NIHR129701: Evidence-based pain management pathway for people with chronic pancreatitis
(Professor Kurinchi Gurusamy, University College London)
Funding Committee recommendation: Decline