Day 1 – Tuesday 17 January 2023
Venue
- Virtual via Microsoft Teams
Present Members
- Rupert Pearse (Chair)
- Nefyn Williams (Deputy Chair)
- Andrew Farmer (Programme Director)
- Amanda Adler
- Mike Bradburn
- Monica Busse
- Andrew Clegg
- Laurentiu Craciunas (Committee Member Development Scheme Participant)
- Nathan Davies
- Rui Duarte
- Saul Faust
- Emilio Fernandez-Egea
- David Gillespie
- Pollyanna Hardy
- Angela Hassiotis
- Liz Hunter (Public Committee Member)
- Trevor Jones (Public Committee Member)
- Easter Joury (Committee Member Development Scheme Participant)
- Sian Lloyd-Jones (Public Committee Member)
- Nick Maskell
- Antonieta Medina-Lara
- Jane Nixon
- Reuben Ogollah
- Ben Ollivere
- Najib Rahman
- Greta Rait
- Rebecca Reynolds
- Pedro Saramago Goncalves
- Andrew Shennan
- Beth Stuart
- Christopher Sutton
- Lyvonne Tume
Secretariat
- James Morris (Consultant Advisor)
- Karen Williams (Senior Research Manager)
- Kathy Tier (Research Manager)
- Daniel Housego (Research Manager)
- Louisa Saunders (Assistant Research Manager)
- Maria Oosterwijk (Administrator)
Apologies
- Galina Velikova
- Andrew Shennan until lunch
Observers
- None
Quoracy information
- Voting members: 31 (Emergency Quoracy = 16 = 50%)
- Voting members present on Day 1: (min) 29 (96%)
Stage 2 applications
21/535 Follow-up strategy after radical treatment for prostate cancer
NIHR150376 - The FOLLOW UP study - a natural experiment comparing the clinical and cost-effectiveness of follow-up strategies after radical treatment for prostate cancer. (Rakesh Heer)
Chair: Rupert Pearse
Conflicts: David Gillespie, Nick Maskell, Beth Stuart, Mike Bradburn, Nefyn Williams
Left the meeting: Rebecca Reynolds
Decision: Programme Oversight Committee to consider fund with changes
22/33 Botulinum toxin in the management of chronic masticatory myofascial pain
NIHR153888 - Managing chronic Myalgia Temporomandibular Disorder (M-TMD): a pragmatic randomised controlled trial of Botulinum toxin type A, Lidocaine, and Amitriptyline/Gabapentin, with internal pilot and cost-effectiveness analysis (MiTiGate trial) (Justin Durham)
Chair: Rupert Pearse
Conflicts: David Gillespie, Easter Joury, Andrew Clegg, Rui Duarte, Pollyanna Hardy
Arrived at the meeting: Rebecca Reynolds
Decision: Programme Oversight Committee to consider fund with changes
21/585 Early endovascular repair in type b uncomplicated sub-acute aortic dissection
NIHR151696 - Early Aortic Repair in patients Needing Endovascular/open Surgery for Type B Aortic Dissection (EARNEST): A randomised trial to assess the clinical and cost-effectiveness of thoracic endovascular aortic repair in the subacute phase after uncomplicated type B aortic dissection. (Colin Bicknell)
Chair: Nefyn Williams
Conflicts: Rupert Pearse
Decision: Programme Oversight Committee to consider fund with changes
22/27 Antipsychotics for the treatment of borderline personality disorder
NIHR152880 - Full Title - The clinical and cost effectiveness of quetiapine for people with borderline personality disorder: A pragmatic, double-blind, placebo-controlled, randomised trial. Short Title - Quetiapine Effectiveness Study in Borderline Personality Disorder (QUEST). (Inti Qurashi)
Chair: Rupert Pearse
Conflicts: Rui Duarte, David Gillespie, Pollyanna Hardy, Christopher Sutton, Nefyn Williams, Emilio Fernandez-Egea, Angela Hassiotis
Decision: Programme Oversight Committee to consider fund with changes
22/34 Surgical and non-surgical management of basal thumb osteoarthritis
Chair: Rupert Pearse
Conflicts: Beth Stuart, Christopher Sutton, Mike Bradburn, Trevor Jones, Saul Faust, Pedro Saramago Goncalves, Andrew Clegg, Reuben Ogollah, Ben Ollivere
NIHR153210 - Short Title Base of thumb arthritis: Therapies, Excision or Replacement? (BETTER) (Sumedh Talwalkar)
Decision: Decline
NIHR154694 - Surgery versus Conservative OsteOarthritis of Thumb Trial (SCOOTT)An RCT to determine clinical and cost effectiveness of treating arthritis of the base of the thumb, with or without surgery, and to determine the clinical and cost effectiveness of trapeziectomy versus base of thumb joint replacement. (Emma Reay)
Decision: Programme Oversight Committee to consider fund with changes
22/32 Biologic disease-modifying anti-rheumatic drugs in pregnancy
Chair: Nefyn Williams
Conflicts: Rebecca Reynolds, Christopher Sutton, Lyvonne Tume, Mike Bradburn, Amanda Adler, Saul Faust, Rupert Pearse, Pollyanna Hardy, Andrew Farmer, Nathan Davies, Angela Hassiotis, Greta Rait, Laurentiu Craciunas
NIHR153577 - The Monoclonal Antibody Medications in inflammatory Arthritis: stopping or continuing in pregnancy (MAMA) trial (Marian Knight)
Decision: Programme Oversight Committee to consider fund with changes
NIHR154385 - Investigating the benefits and harms of continuing biologic disease-modifying anti-rheumatic drugs (bDMARDs) compared with withdrawing bDMARDs in pregnant women with rheumatoid & other inflammatory arthritis? (Ian Giles)
Decision: Decline
22/35 Thromboprophylaxis in lower limb immobilisation
NIHR154716 - Thromboprophylaxis in Lower Limb Immobilisation (TiLLI): a study comprising two linked randomised controlled trials evaluating the effectiveness and cost effectiveness of different methods of pharmacological prophylaxis for patients with temporary lower limb immobilisation (Daniel Horner)
Chair: Nefyn Williams
Conflicts: Nathan Davies, Greta Rait, Beth Stuart, Andrew Farmer, Rupert Pearse, Amanda Adler, Andrew Clegg, Mike Bradburn, Easter Joury
Arrived at the meeting: Andrew Shennan
Decision: Programme Oversight Committee to consider fund with changes
22/30 Post-operative pain in patients undergoing spinal surgery
Chair: Nefyn Williams
Conflicts: Andrew Farmer, David Gillespie, Beth Stuart, Mike Bradburn, Saul Faust, Reuben Ogollah, Rupert Pearse, Rui Duarte, Ben Ollivere, Easter Joury
NIHR152886 - Erector Spinae Plane blockade or INtrathecAL opioids for analgesia following spinal surgery (SPINAL). (David Hewson)
Decision: Decline
NIHR153170 - Pain Relief After Instrumented Spinal surgEry trial (PRAISE Trial) (Matthew Wilson)
Decision: Programme Oversight Committee to consider fund with changes
22/31 Glucagon-like peptide-1 receptor agonist therapy for people with severe mental illness living with overweight or obesity
Chair: Rupert Pearse
Conflicts: Greta Rait, Mike Bradburn, Nathan Davies, Angela Hassiotis, Andrew Farmer, Emilio Fernandez-Egea, Rui Duarte, Beth Stuart, Christopher Sutton, Nefyn Williams, Saul Faust, Pedro Saramago Goncalves, Laurentiu Craciunas
NIHR153463 - SEmaglutide for the management of weight In Severe Mental Illness Conditions: SEISMIC randomised controlled trial (Artemis Igoumenou)
Decision: Decline Return to POC
NIHR154249 - The effectiveness and cost-effectiveness of Semaglutide in people with severe Mental ILlnEss living with overweight or obesity (SMILE) (Fiona Gaughran)
Decision: Decline Return to POC
Stage 1 applications
22/90 Self-care of children and young people with neurodisability
Chair: Rupert Pearse
Conflicts: David Gillespie, Angela Hassiotis, Christopher Sutton,Pollyanna Hardy, Beth Stuart
NIHR155930 - ACHIEVE (AdolesCents Home based InterVEntion Study) - Improving self-care for adolescents with learning disabilities (Jill Bradshaw)
Decision: Decline
NIHR156487 - Investigating the clinical and cost-effectiveness of CHildren’s Early Self-care Support in children with neurodisability: the CHESS cluster randomised controlled trial (Niina Kolehmainen) Decision: Shortlist
22/91 Rescue packs in chronic obstructive pulmonary disease
Chair: Rupert Pearse
Conflicts: Pollyanna Hardy, Nick Maskell, Lyvonne Tume, Andrew Clegg, Saul Faust, David Gillespie, Najib Rahman, Andrew Farmer, Monica Busse, Beth Stuart, Christopher Sutton, Nefyn Williams
NIHR156698 - Rescue packs post-discharge in chronic obstructive pulmonary disease (The RAPID study) (Mona Bafadhel)
Decision: Shortlist
NIHR156744 - Data-Enabled Trial of Rescue packs to prevent hOspITal readmission after an acute exacerbation of COPD (DETROIT) (David Gillespie)
Decision: Shortlist
22/92 Withdrawing long term macrolides in bronchiectasis
NIHR156597 - Bronchiectasis: Optimising Azithromycin prevention Treatment to reduce exacerbations (BOAT): A double blind pragmatic randomised controlled trial (Anthony De-Soyza)
Chair: Nefyn Williams
Conflicts: Najib Rahman
Left the meeting: Andrew Shennan
Decision: Shortlist
22/94 Optimal management of perianal Crohn’s disease
NIHR157164 - Randomised evaluation of surgical techniques for anal fistula repair in patients with Crohn’s disease using a trials within cohort design - 'Repair pCD' (Phil Tozer)
Chair: Nefyn Williams
Conflicts: David Gillespie, Beth Stuart, Saul Faust, Andrew Farmer, Rupert Pearse, Greta Rait, Reuben Ogollah
Decision: Decline return to POC
22/93 The clinical and cost-effectiveness of colesevelam for the treatment of bile acid diarrhoea
NIHR156493 - COlesevelam for Bile Acid diarrhoea: clinical and cost effectiveness with Long Term follow-up. (COBALT) (Ramesh Arasaradnam)
Chair: Rupert Pearse
Conflicts: Rui Duarte, Pollyanna Hardy
Decision: Decline Return to POC
Day 2 - Wednesday 18 January 2023
Venue
- Virtual via Microsoft Teams
Present Members
- Rupert Pearse (Chair)
- Nefyn Williams (Deputy Chair)
- Andrew Farmer (Programme Director)
- Amanda Adler
- Mike Bradburn
- Monica Busse
- Andrew Clegg
- Laurentiu Craciunas (Committee Member Development Scheme Participant)
- Nathan Davies
- Rui Duarte
- Saul Faust
- Emilio Fernandez-Egea
- David Gillespie
- Pollyanna Hardy
- Angela Hassiotis
- Liz Hunter (Public Committee Member)
- Trevor Jones (Public Committee Member)
- Easter Joury (Committee Member Development Scheme Participant)
- Sian Lloyd-Jones (Public Committee Member)
- Nick Maskell
- Antonieta Medina-Lara
- Jane Nixon
- Reuben Ogollah
- Ben Ollivere
- Najib Rahman
- Greta Rait
- Rebecca Reynolds
- Beth Stuart
- Christopher Sutton
- Lyvonne Tume
Secretariat
- James Morris (Consultant Advisor)
- Karen Williams (Senior Research Manager)
- Kathy Tier (Research Manager)
- Daniel Housego (Research Manager)
- Louisa Saunders (Assistant Research Manager)
- Maria Oosterwijk (Administrator)
Apologies
- Galina Velikova
- Andrew Shennan
- Lyvonne Tume until 11am
- Pedro Saramago Goncalves
Observers
- None
Quoracy information
- Voting members: 31 (Emergency Quoracy = 16 = 50%)
- Voting members present on Day 2: (min) 27 (87 %)
Stage 2 applications
22/104 HTA Application Acceleration Award – platform studies in areas considered strategic priorities
NIHR155476 - Development of a Platform Trial in Paediatric Intensive Care (Paul Mouncey)
Chair: Rupert Pearse
Conflicts: Pollyanna Hardy, Nefyn Williams, Rui Duarte
Decision: Programme Oversight Committee to consider fund with changes
NIHR155477 - Venous leg ulcErs: management and eradication, the VEIN Platform Study (Alun Davies)
Chair: Rupert Pearse
Conflicts: Rui Duarte, Antonieta Medina-Lara, Jane Nixon, Greta Rait, Pollyanna Hardy, Christopher Sutton
Decision: Programme Oversight Committee to consider fund with changes
NIHR156219 - Creating a national platform trial for Acute Kidney Injury (Nicholas Selby)
Chair: Nick Maskell
Conflicts: Beth Stuart, Christopher Sutton, Lyvonne Tume, Monica, Busse, David Gillespie, Pollyanna Hardy, Rupert Pearse, Andrew Farmer, Nefyn Williams, Najib Rahman
Decision: Decline
NIHR156228 - COMBINING WEIGHT LOSS, PHYSICAL ACTIVITY AND SLEEP INTERVENTIONS IN THE MANAGEMENT OF TYPE 2 DIABETES: A MULTI-ARM, MULTI-STAGE TRIAL (Thomas Yates)
Chair: Nefyn Williams
Conflicts: Amanda Adler, Mike Bradburn
Decision: Decline
NIHR156397 - Diabetic Foot Ulcer REsearch PlatFORM – DFU-REFORM (Jane Nixon)
Chair: Rupert Pearse
Conflicts: Nick Maskell, Jane Nixon, Andrew Clegg
Decision: Programme Oversight Committee to consider fund with changes
NIHR156509 - Personalised and novel therapies for recurrent head or neck cancer through adaptive platform trials (PANTHEoN) (Ben O'Leary)
Chair: Rupert Pearse
Conflicts: Nefyn Williams
Decision: Decline
22/104 HTA Application Acceleration Award – platform studies in areas considered strategic priorities
Chair: Rupert Pearse
Conflicts: Nathan Davies, Antonieta Medina-Lara, Christopher Sutton, Nefyn Williams, Reuben Ogollah, Rebecca Reynolds, Trevor Jones, Jane Nixon, Andrew Clegg
Arrived at the meeting: Lyvonne Tume
NIHR155217 - UK Stroke Trials Effectiveness Platform (UK STEP) (Philip Bath)
Decision: Decline
NIHR156616 - Developing a national platform for delivering efficient trials for people living with stroke: Life After Stroke Platform (LEAP) (Amanda Farrin)
Decision: Programme Oversight Committee to consider fund with changes
NIHR156550 - Prehospital Point of Care Testing to Enable Decision-making (PrePoCTED) (Jonathan Benger)
Chair: Rupert Pearse
Conflicts: Nick Maskell, Pollyanna Hardy, Christopher Sutton, Saul Faust
Decision: Programme Oversight Committee to consider fund with changes
22/104 HTA Application Acceleration Award – platform studies in areas considered strategic priorities
Chair: Rupert Pearse
Conflicts: David Gillespie, Nick Maskell, Jane Nixon, Greta Rait, Beth Stuart, Christopher Sutton, Amanda Adler, Saul Faust, Andrew Clegg, Najib Rahman, Andrew Farmer, Rui Duarte, Pollyanna Hardy, Nefyn Williams, Monica Busse, Antonieta Medina-Lara
Left the meeting: Lyvonne Tume
NIHR156089 - Digitally Enabled platForm EvaluatioN of Diagnostics for AntiMicrobial Prescribing (DEFEND AMP) (Martin Llewelyn)
Decision: Decline
NIHR156664 - Platform Randomised evaluation of clinical Outcomes using novel TEChnologies to optimise antimicrobial Therapy (PROTECT) (Philip Pallmann)
Decision: Programme Oversight Committee to consider fund with changes
NIHR156512 - Optimising recovery from brain injury following cardiac arrest: development of a trial platform (Keith Couper)
Chair: Rupert Pearse
Conflicts: Lyvonne Tume
Decision: Decline
NIHR156028 - PRACTISE - AF: Platform tRiAl to improve outComes afTer cardIac SurgEry – Atrial Fibrillation (Accelerator Award) (Ben Gibbison)
Chair: Nefyn Williams
Conflicts: Nick Maskell, Andrew Clegg, Rupert Pearse
Left the meeting: Laurentiu Craciunas
Decision: Programme Oversight Committee to consider fund with changes
NIHR156043 - Accelerating the development of a perinatal platform trial to efficiently evaluate the effectiveness of multiple interventions in maternity and neonatal care (Ed Juszczak)
Chair: Nefyn Williams
Conflicts: Beth Stuart, Lyvonne Tume, Mike Bradburn, Saul Faust, Rupert Pearse, Pollyanna Hardy, Trevor Jones, Reuben Ogollah, Andrew Farmer, Najib Rahman, Ben Ollivere
Left the meeting: Angela Hassiotis
Decision: Programme Oversight Committee to consider fund with changes
NIHR156728 - ROSSINI-Platform - Reduction Of Surgical Site Infection with a platform trial utilising a 'Basket-MAMS' design - Application Accelerator Award (Thomas Pinkney)
Chair: Andrew Farmer
Conflicts: Rui Duarte, Jane Nixon, Amanda Adler, Rupert Pearse, Pedro Saramago Goncalves, Pollyanna Hardy, Greta Rait, Nefyn Williams
Arrived at the meeting: Lyvonne Tume
Decision: Programme Oversight Committee to consider fund with changes
NIHR156925 - MONITOR-PsA 2 – Multicentre Observational Network in Treatment Outcomes Research in PsA-2 (Laura Coates)
Chair: Rupert Pearse
Conflicts: David Gillespie, Andrew Clegg, Andrew Farmer, Najib Rahman
Decision: Decline
NIHR155342 - Designing a platform trial to assess the effectiveness of interventions for peripheral arterial disease: The PAEDIS trial development project. (Athanasios Saratzis)
Chair: Nefyn Williams
Conflicts: Rui Duarte, Antonieta Medina-Lara, Jane Nixon, Rebecca Reynolds, Pollyanna Hardy
Decision: Programme Oversight Committee to consider fund with changes
Stage 1 Applications
22/85 Positive airway pressure therapy in chronic obstructive pulmonary disease-obstructive sleep apnoea overlap syndrome
NIHR154890 - Exacerbation Prevention in COPD-OSA overlap syndrome (EPiC-OSA) (Patrick Murphy)
Chair: Rupert Pearse
Conflicts: Saul Faust, Najib Rahman, Andrew Farmer
Decision: Shortlist
22/86 Surgical management of successfully reduced incarcerated inguinal hernia in children
Chair: Rupert Pearse
Conflicts: Rui Duarte, Pollyanna Hardy, Lyvonne Tume, Saul Faust
NIHR156482 - Emergency vs elective repair of successfully reduced incarcerated inguinal hernia in children (Nigel Hall)
Decision: Decline Return to POC
NIHR157263 - INdex admission Compared to Arranged repair of successfully Reduced inCarcerated inguinal hERniA in children- a randomised controlled Trial - INCARCERAT (Bashar Aldeiri)
Decision: Decline
22/88 Repetitive Transcranial Magnetic Stimulation for depression in adolescents
NIHR156157 - The clinical and cost-effectiveness of intermittent THeta-burst REpetitive transcranial magnetic stimulation for the treatment of Adolescent Depression: iTHREAD (Jack Rogers)
Chair: Nefyn Williams
Conflicts: Rui Duarte, Trevor Jones, Greta Rait, Beth Stuart, Christopher Sutton, Nathan Davies, Pollyanna Hardy, Angela Hassiotis
Left the meeting: Ben Ollivere
Decision: Decline Return to POC
22/123 Comprehensive geriatric assessment for frail older heart failure patients with preserved ejection fraction
Chair: Greta Rait
Conflicts: Jane Nixon, Antonieta Medina-Lara, Nefyn Williams, Andrew Clegg, Andrew Farmer, Pollyanna Hardy ,Amanda Adler, Rupert Pearse
NIHR155936 - Comprehensive geriatric assessment to sustain independence for older people living with heart failure with preserved ejection fraction and frailty (Andrew Clegg)
Decision: Shortlist
NIHR157102 - The PRESERVE-CGA randomised trial: Proactive patient-centred, geriatrician-led Comprehensive Geriatric Assessment for frail older adults with heart failure PRESERVEd ejection fraction. (Rebekah Schiff)
Decision: Shortlist
22/89 Janus kinase inhibitors for the treatment of juvenile idiopathic arthritis
NIHR154877 - A multi-centre, open-label, randomised controlled trial of tofacitinib versus adalimumab in children and young people with active polyarticular-course juvenile idiopathic arthritis who have had inadequate response or intolerance to methotrexate (Ethan Sen)
Chair: Rupert Pearse
Conflicts: David Gillespie, Saul Faust, Andrew Clegg
Decision: Shortlist