Day 1 - 16 May 2023
Venue
Danubius Hotel, Regent's Park, London
Present members
- Rupert Pearse (Chair)
- Nefyn Williams (Deputy Chair)
- Andrew Farmer (Programme Director)
- Amanda Adler
- Mike Bradburn
- Miriam Brazzelli
- Andrew Clegg
- Nathan Davies
- Rui Duarte
- Saul Faust
- Emilio Fernandez-Egea
- David Gillespie
- Amy Grove (Committee Member Development Scheme participant)
- Pollyanna Hardy
- Angela Hassiotis
- Trevor Jones (Public Committee Member)
- Easter Joury (Committee Member Development Scheme participant)
- Sian Lloyd-Jones (Public Committee Member)
- Jane Nixon
- Reuben Ogollah
- Ben Ollivere
- Najib Rahman
- Greta Rait
- Rebecca Reynolds
- Pedro Saramago Goncalves
- Beth Stuart
- Christopher Sutton
Secretariat
- Jason Horsley
- Karen Williams
- Kathy Tier
- Hebe Sims
- Louisa Saunders
Apologies
- Monica Busse
- Antonieta Medina-Lara
- Lyvonne Tume
- Liz Hunter
Observers
- None
Quoracy information
- Voting members: 33 (emergency quoracy = 17 = 50%)
- Voting members present on day 1: 29 (88 %)
Stage 2 applications
22/90 Self-care of children and young people with neurodisability
NIHR156487 - Investigating the clinical and cost-effectiveness of CHildren’s Early Self-care Support in children with neurodisability: the CHESS cluster randomised controlled trial (Niina Kolehmainen)
Chair: Rupert Pearse
Conflicts: David Gillespie, Pollyanna Hardy, Greta Rait, Christopher Sutton. Beth Stuart, Miriam Brazzelli
Decision: Programme Oversight Committee to consider fund with changes
22/85 Positive airway pressure therapy in chronic obstructive pulmonary disease-obstructive sleep apnoea overlap syndrome
NIHR154890 - Exacerbation Prevention in COPD-OSA overlap syndrome (EPiC-OSA) (Patrick Murphy)
Chair: Rupert Pearse
Conflicts: Najib Rahman, Andrew Farmer
Decision: Programme Oversight Committee to consider fund with changes
22/92 Withdrawing long-term macrolides in bronchiectasis
NIHR156597 - Bronchiectasis: Optimising Azithromycin prevention Treatment to reduce exacerbations (BOAT): A double blind pragmatic randomised controlled trial (Anthony De-Soyza)
Chair: Nefyn Williams
Conflicts: David Gillespie, Beth Stuart, Saul Faust, Najib Rahman
Decision: Programme Oversight Committee to consider fund with changes
22/89 Janus kinase inhibitors for the treatment of juvenile idiopathic arthritis
NIHR154877 - A multi-centre, open-label, randomised, non-inferiority trial of tofacitinib versus adalimumab in children and young people with active polyarticular-course juvenile idiopathic arthritis or juvenile psoriatic arthritis who have had inadequate response or intolerance to methotrexate (Ethan Sen)
Chair: Rupert Pearse
Conflicts: David Gillespie, Saul Faust, Andrew Clegg
Decision: Re-submission at stage 2
22/123 Comprehensive geriatric assessment for frail older heart failure patients with preserved ejection fraction
Chair: Rupert Pearse
Conflicts: Andrew Farmer, Beth Stuart, Nefyn Williams, Pedro Saramago Goncalves, Jane Nixon, Andrew Clegg, Amanda Adler, Rebecca Reynolds, Pollyanna Hardy
NIHR155936 - Comprehensive geriatric assessment to sustain independence for older people living with heart failure with preserved ejection fraction and frailty (Andrew Clegg)
Decision: Programme Oversight Committee to consider fund with changes
NIHR157102 - The PRESERVE CGA randomised trial: Proactive patient-centred, geriatrician-led Comprehensive Geriatric Assessment for frail older adults with heart failure preserved ejection fraction (Rebekah Schiff)
Decision: Decline
22/91 Rescue packs in chronic obstructive pulmonary disease
Chair: Rupert Pearse
Conflicts: Andrew Farmer, Beth Stuart, Saul Faust, David Gillespie, Najib Rahman, Christopher Sutton, Nefyn Williams
NIHR156698 - Rescue packs post-discharge in chronic obstructive pulmonary disease (The RAPID study) (Mona Bafadhel)
Decision: Programme Oversight Committee to consider fund with changes
NIHR156744 - Data-Enabled Trial of Rescue packs to prevent hOspITal re-admission after an acute exacerbation of COPD (DETROIT) (David Gillespie)
Decision: Decline
Stage 1 applications
22/133 Point of care Doppler ultrasound prior to emergency scrotal exploration - re-submission
NIHR156285 - Rapid Evaluation of the SCrotum with Ultrasound prior to Exploration (RESCUE). Point of Care Ultrasound in suspected testicular torsion: a diagnostic test accuracy study (Veeru Kasivisvanathan)
Chair: Rupert Pearse
Conflicts: Rui Duarte, Pollyanna Hardy, Amy Grove, Nathan Davies, Greta Rait, Miriam Brazzelli, Saul Faust
Decision: Shortlist
22/146 Maintenance treatment for bipolar disorder
NIHR158667 - The effectiveness of Lithium plus Quetiapine COMBination versus LithIum versus QuetiapiNe monothErapy in the maintenance treatment of bipolaR disorder: the COMBINER trial (Steven Marwaha)
Chair: Nefyn Williams
Conflicts: Rui Duarte, Ben Ollivere, Christopher Sutton, Pollyanna Hardy, Trevor Jones, Angela Hassiotis
Decision: Shortlist
22/150 Intravesical treatments for recurrent urinary tract infection (rUTI) in women
Chair: Rupert Pearse
Conflicts: Andrew Farmer, Nathan Davies, Pollyanna Hardy, Beth Stuart, Christopher Sutton, Pedro Saramago Goncalves, Amy Grove, David Gillespie, Saul Faust, Angela Hassiotis, Greta Rait
NIHR158130 - IntraVESical Preparations for Recurrent Urinary TrAct Infection Prevention (The VESPA Study): a multi-arm, multi-site open label randomised superiority trial (Christopher Harding)
Decision: Shortlist
NIHR158512 - Intravesical Treatments for recurrent UTI (Rajvinder Khasriya)
Decision: Shortlist
NIHR158568 - Bladder INstillations in recurrent Urinary Tract Infections (BIN-rUTI): An examination of the clinical and cost-effectiveness (Pallavi Latthe)
Decision: Decline
NIHR157883 - Intravesical instillations for treating recurrent urinary tract infections in women: a multi-centre randomised controlled a hybrid type 1 trial (Nicholas Raison)
Decision: Decline
22/147 Pseudomonas aeruginosa eradication treatment in bronchiectasis
NIHR158726 - Exacerbation and Symptom Control After Pseudomonas Eradication Treatment in Adult Bronchiectasis: a multi-centre randomised controlled trial (ESCAPE) (James Chalmers)
Chair: Rupert Pearse
Conflicts: None
Decision: Decline Return to POC
22/148 Surgical treatment of proximal ACL ruptures with ACL repair or ACL reconstruction
Chair: Nefyn Williams
Conflicts: Ben Ollivere, Christopher Sutton, Amanda Adler, Andrew Farmer, Pollyanna Hardy, Amy Grove, Najib Rahman, Miriam Brazzelli, Greta Rait, Rebecca Reynolds
NIHR157938 - ACL STARR - Anterior Cruciate Ligament Stratified Accelerated Repair or Reconstruction Single blind randomised control trial for patients with proximal ACL injuries treatment with ACL repair v ACL reconstruction (Stephen McDonnell)
Decision: Shortlist
NIHR158440 - AURORA Study – Anterior Cruciate Ligament Reconstruction or Repair (Mark Blyth)
Decision: Shortlist
22/158 Inhibition of the renin-angiotensin system in takotsubo cardiomyopathy
NIHR157523 - A Randomised Controlled Trial of Renin-Angiotensin Inhibition for Cardiovascular Events Reduction after Takotsubo Cardiomyopathy (EVEREST) (Dana Dawson)
Chair: Rupert Pearse
Conflicts: Rebecca Reynolds, Andrew Clegg, Miriam Brazzelli, Andrew Farmer
Decision: Re-submission at stage 1
22/152 Through-knee versus above-knee major limb amputation
NIHR157343 - Through-knee Amputations impact on Quality of Life compared to Above Knee Amputations - The HAMLET Trial (George Smith)
Chair: Nefyn Williams
Conflicts: Jane Nixon, Christopher Sutton, Pedro Saramago Goncalves, Andrew Clegg
Decision: Shortlist
Day 2 – 17 May 2023
Venue
Danubius Hotel, Regent's Park, London
Present members
- Rupert Pearse (Chair)
- Nefyn Williams (Deputy Chair)
- Andrew Farmer (Programme Director)
- Amanda Adler
- Mike Bradburn
- Miriam Brazzelli
- Andrew Clegg
- Nathan Davies
- Rui Duarte
- Saul Faust
- Emilio Fernandez-Egea
- David Gillespie
- Amy Grove (Committee Member Development Scheme participant)
- Pollyanna Hardy
- Angela Hassiotis
- Trevor Jones (Public Committee Member)
- Easter Joury (Committee Member Development Scheme participant)
- Sian Lloyd-Jones (Public Committee Member)
- Jane Nixon
- Reuben Ogollah
- Ben Ollivere
- Najib Rahman
- Greta Rait
- Rebecca Reynolds
- Pedro Saramago Goncalves
- Beth Stuart
- Christopher Sutton
Secretariat
- Jason Horsley
- Karen Williams
- Kathy Tier
- Hebe Sims
Apologies
- Monica Busse
- Antonieta Medina-Lara
- Lyvonne Tume
- Liz Hunter
Observers
- None
Quoracy Information
- Voting members: 33 (emergency quoracy = 17 = 50%)
- Voting members present on day 2: 29 (88 %)
22/149 Surgery for pectus excavatum
NIHR158749 – A randomiseded trial of surgery versus no treatment to RESTORE cardiopulmonary function in severe pectus excavatum – The RESTORE Trial (Enoch Akowuah)
Chair: Rupert Pearse
Conflicts: David Gillespie, Andrew Clegg, Andrew Farmer
Decision: Shortlist
22/168 The diagnostic accuracy of colon capsule endoscopy
Chair: Rupert Pearse
Conflicts: Greta Rait, Beth Stuart, Christopher Sutton, Mike Bradburn, David Gillespie, Miriam Brazzelli, Rebecca Reynolds
NIHR158034 - Colo-Cap: determining the diagnostic accuracy of colon capsule endoscopy compared to standard colonoscopy in patients at risk of colorectal disease (James Turvill)
Decision: Shortlist
NIHR158780 - The diagnostic accuracy of colon capsule endoscopy - FIT for purpose? (Hugh Paterson)
Decision: Shortlist
22/167 Imaging pathways for investigation following heart failure diagnosis
Chair: Nefyn Williams
Conflicts: Pollyanna Hardy, Mike Bradburn, Jane Nixon
NIHR158285 - IMaging PAthway for the Cardiac aeTiology of Heart Failure (IMPACT-HF Trial) (Abdallah Al-Mohammad)
Decision: Decline
NIHR159132 - CROSS sectional versus invasive imaging in patients with Heart Failure (CROSS-HF) (Peter Swoboda)
Decision: Shortlist
22/155 Oral versus intramuscular glucocorticoids in rheumatoid arthritis
Chair: Nefyn Williams
Conflicts: Andrew Farmer, Rui Duarte, Pollyanna Hardy, Reuben Ogollah, Amy Grove, Ben Ollivere, Christopher Sutton, Najib Rahman
NIHR158151 - Injection Versus Steroid Tablets in Rheumatoid Arthritis (InVeST-RA) (Samantha Hider)
Decision: Shortlist
NIHR158471 - The clinical and cost effectiveness of oraL vErsus intrAmuscular glucocorticoiDs in rhEumatoid aRthritis: LEADER A Randomised Controlled Trial (James Bluett)
Decision: Shortlist
22/157 Interventions to reduce hospital-based medication administration errors
NIHR158228 - REducing Medication administration Errors using Digital technologY - REMEDY: an evaluation of the effectiveness of barcode medication administration (BCMA) systems in two English hospitals (Yogini Jani)
Chair: Rupert Pearse
Conflicts: Nathan Davies, Greta Rait
Decision: Decline
22/157 Interventions to reduce hospital-based medication administration errors
NIHR158316 - Is self-checking of injectable medicines no less effective and more cost-effective than second-person checking in preventing medication administration errors in hospital inpatients? A cluster randomised controlled trial (‘CheckMed’) (Bryony Franklin (nee Dean))
Chair: Rupert Pearse
Conflicts: Beth Stuart, Pedro Saramago Goncalves, Christopher Sutton
Decision: Decline return to POC
22/156 Children and young people's mental health
Chair: Nefyn Williams
Conflicts: Emilio Fernandez-Egea, Pollyanna Hardy, Rebecca Reynolds, Christopher Sutton, Andrew Farmer, Najib Rahman
NIHR157687 - ASTAR2: A randomised controlled trial of Predictive Parenting to reduce mental health and behaviour problems in young autistic children (Emily Simonoff)
Decision: Shortlist
NIHR157696 - Clinical and cost-effectiveness of adapted online parent-led treatment compared to treatment as usual for autistic children with anxiety problems in Child and Adolescent Mental Health Services: A randomised controlled trial (Cathy Creswell)
Decision: Shortlist
22/156 Children and young people's mental health
NIHR158299 - Safety Nets: A randomised controlled trial to test the clinical and cost-effectiveness of a social prescribing intervention to support young people accessing child and adolescent mental health services (CAMHS) (Hannah Armitt)
Chair: Rupert Pearse
Conflicts: Pedro Saramago Goncalves
Decision: Shortlist
22/156 Children and young people's mental health
NIHR158356 - Leveraging Big Data Science to elucidate the long-term effectiveness and safety of licenced and unlicenced antidepressant medications and polypharmacy prescribing practice for Emotional disorders in children and young people (Alex Dregan)
Chair: Rupert Pearse
Conflicts: Rebecca Reynolds
Decision: Decline
22/156 Children and young people's mental health
NIHR158680 - An inclusive approach to supporting young children with anxiety in mental health services: An individually randomised controlled effectiveness trial of the Fear-Less intervention (Fear-Less Trial) (Rachel McNamara)
Chair: Rupert Pearse
Conflicts: Angela Hassiotis, Andrew Farmer, David Gillespie, Amy Grove
Decision: Decline
22/156 Children and young people's mental health
NIHR158942 - Development of digital psychological and social support for young people living with post-acne scarring and hyperpigmentation (Rachael Pattinson)
Chair: Nefyn Williams
Conflicts: None
Decision: Decline
22/166 Rehabilitation and care following stroke
NIHR157510 - REmote STrOke REhabilitation (ReSTORe): A randomised controlled trial with embedded process evaluation and economic analysis to test the effectiveness of an online group physical and mental health rehabilitation intervention for long-term stroke survivors (Gordon McGregor)
Chair: Rupert Pearse
Conflicts: Rui Duarte, Mike Bradburn, Amy Grove
Decision: Shortlist
22/166 Rehabilitation and care following stroke
NIHR157876 - Randomised controlled trial of an adapted cardiac rehabilitation programme for people with minor stroke: a personalised pathway for managing hidden needs and reducing risk (Neil Heron)
Chair: Nefyn Williams
Conflicts: Beth Stuart, Christopher Sutton, Andrew Clegg, Reuben Ogollah
Decision: Decline
22/166 Rehabilitation and care following stroke
NIHR158240 - A randomised controlled trial to evaluate the clinical and cost-effectiveness of the Action Falls rehabilitation programme compared to usual care alone to reduce falls in stroke survivors (Philippa Logan)
Chair: Rupert Pearse
Conflicts: Pollyanna Hardy, Beth Stuart, Christopher Sutton, Nefyn Williams, Pedro Saramago Goncalves, Andrew Clegg, Andrew Farmer, Trevor Jones, Reuben Ogollah, Ben Ollivere
Decision: Shortlist
22/166 Rehabilitation and care following stroke
NIHR158951 - Walking in the home and community after stroke: a pragmatic multi-centre randomised controlled trial to evaluate auditory rhythmical cueing training compared to walking training alone and usual NHS care (ACTIVATE2) (Sarah Moore)
Chair: Nefyn Williams
Conflicts: None
Decision: Shortlist
22/166 Rehabilitation and care following stroke
NIHR159084 - UTILISE: Telehealth for post-stroke aphasia (Rosemary Varley)
Chair: Rupert Pearse
Conflicts: Nathan Davies, Pollyanna Hardy, Angela Hassiotis, Greta Rait, Christopher Sutton
Left the meeting: Ben Ollivere
Decision: Decline