Tuesday 14 July 2020 (Day 1)
Place
Virtual Meeting via Microsoft Teams
Present members
Professor Andrew Farmer (Chair)
Professor Olivia Wu (Deputy Chair)
Professor Hywel Williams (Programme Director)
Professor Julie Brittenden
Professor Matthew Costa
Dr Fay Crawford
Professor Jo Dumville
Professor Nick Francis
Professor Caroline Free
Professor Colin Green
Professor Kerenza Hood
Professor Nick James
Professor Asma Khalil
Professor Steff Lewis
Dr Rumana Omar
Professor Rupert Pearse
Professor Mark Peters
Professor Craig Ramsay
Mrs Amanda Roberts (PPI)
Professor Christine Roffe
Associate Professor Jo Thompson-Coon
Dr Marc Serfaty
Dr Sarah Stock
Dr Sara Twaddle
Dr Whitney Scott
Mr Dave Green (PPI)
NETSCC, HTA Secretariat
Dr Simon Fraser (Consultant Advisor).
Steph Garfield-Birkbeck (Head of the HTA Programme
Karen Williams (Senior Research Manager)
Cristina Lujan Barroso (Research manager)
Louisa Saunders (Assistant Research Manager)
Julie Herring (Administrator)
Apologies
Professor Simon Gates
Observers
None
Quoracy Information
Voting members: 26 Quorum = 18
Voting members present on Day 1: 25 (96%)
19/102 HTA Researcher-led call Primary Research, shortlisted at March Funding Committee
NIHR130875: The impact of REstrictive versUs Liberal Transfusion strategy on cardiac Injury in patients undergoing surgery for Hip Fracture (RESULT-HF)
(Honorary Professor Michael Gillies, NHS Lothian)
Chair: Professor Olivia Wu
Declared a conflict and did not partake in the discussion or vote: Professor Rupert Pearse, Professor Matthew Costa, Professor Andrew Farmer, Professor Steff Lewis, Professor Jo Dumville
Declared a conflict and left the call: Professor Hywel Williams, Dr Sarah Stock
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
NIHR131334: The Self-harm, Assessment, Formulation, Engagement Trial of Psychodynamic Interpersonal Therapy (SAFE-PIT)
(Professor Elspeth Guthrie, University of Leeds)
Chair: Professor Andrew Farmer
Declared a conflict: None
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
NIHR131362: The HER2-RADiCAL study (Response ADaptive CAre pLan) - tailoring treatment for HER2 positive early breast cancer
(Professor Andrew Wardley, The Christie NHS Foundation Trust)
Chair: Professor Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Steff Lewis, Nick James
Declared a conflict and left the call: Olivia Wu
Left meeting: Julie Brittenden
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/59 HTA Researcher-led call Primary Research, shortlisted at November 2019 Funding Committee
NIHR129926: Best systemic treatments for adults with atopic eczema over the long term (BEACON): A randomised, assessor-blind trial comparing ciclosporin, methotrexate and dupilumab
(Professor Catherine Smith, Guy's and St Thomas' NHS Foundation Trust)
Chair: Professor Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Professor Kerenza Hood, Professor Rumana Omar and Professor Nick Francis.
Declared a conflict and left the call: Professor Hywel Williams, Mrs Amanda Roberts
Arrived meeting: Julie Brittenden
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/101 HTA Researcher-led call Evidence Synthesis
NIHR130664: Systematic review and meta-analysis of behaviour change interventions to promote long-term physical activity in people with intermittent claudication
(Dr Ukachukwu Abaraogu, Glasgow Caledonian University)
Chair: Professor Olivia Wu
Declared a conflict and did not partake in the discussion or vote: Dr Sarah Stock, Professor Steff Lewis.
Declared a conflict and left the call: Professor Julie Brittenden
Funding Committee recommendation: Resubmission as stage 2.
Commissioning Stage 2 Proposals
19/72 Pain relief strategies for dressing change in chronic wounds
Chair: Professor Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Professor Jo Dumville
NIHR131023: Pain relief strategies for dressing change in chronic wounds: a mixed-methods systematic review and survey of UK practice
(Dr Marrissa Martyn-St James, The University of Sheffield)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
NIHR131433: Optimal Pain Relief Strategies at Dressing Change for Chronic Wounds.
(Dr Gwenllian Wynne-Jones, Keele University)
Funding Committee recommendation: Decline
19/132 A clinical prediction rule for post-operative atrial fibrillation in patients undergoing cardiac surgery
Chair: Professor Olivia Wu
Declared a conflict and did not partake in the discussion or vote: Professor Andrew Farmer
Declared a conflict and left the call: Professor Rupert Pearse
NIHR131227: Predicting AF after Cardiac Surgery - the PARADISE Score
A Clinical Prediction Rule for Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
(Professor Benjamin O'Brien, Barts Health NHS Trust)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
NIHR131476: Development and evaluation of a novel real-time dynamic model for the prediction of atrial fibrillation after cardiac surgery
(Mr Stuart Grant, The University of Manchester)
Funding Committee recommendation: Decline
Cross-Programme Commissioning Stage 2 Proposals
19/143 HTA Liver Disease
Chair: Professor Andrew Farmer
Declared a conflict and left the call: Dr Simon Fraser, Professor Hywel Williams
NIHR131059: Palliative Long-term Abdominal Drains Versus Repeated Drainage in Untreatable Ascites Due To Advanced Cirrhosis: A Randomised Controlled Trial
(Professor Sumita Verma, University of Sussex)
Funding Committee recommendation: Decline
Cross-Programme Commissioning Stage 1 proposals
19/155 HTA Oral and Dental Health
Chair: Professor Andrew Farmer
Declared a conflict: None
Left Meeting: Sarah Stock
NIHR131786: Randomised Evaluation of Supportive PEriodontal Care/Therapy (SPT) delivered by an upskilled dental Team versus standard of care in adults treated for periodontitis (RESPECTT)
(Professor Nikolaos Donos, Queen Mary University of London)
Committee recommendation: Decline
19/155 HTA Oral and Dental Health
Chair: Professor Andrew Farmer
Declared a conflict: None
Left Meeting: Professor Nick Francis, Professor Craig Ramsay.
NIHR131901: Avoiding GA Paediatric Extractions- AGAPE Trial
(Professor Marie Therese Hosey, King's College London)
Committee recommendation: Decline
19/155 HTA Oral and Dental Health
Chair: Professor Andrew Farmer
Declared a conflict: None
NIHR131817: Changing Habits to Prevent Child Caries: A Randomized Controlled Trial of a Family-Focused Therapeutic Conversation Delivered by Dental Nurses in Primary Care [CHOICE Trial]
(Dr Pauline Adair, The Queen's University of Belfast)
Committee recommendation: Shortlist
19/155 HTA Oral and Dental Health
Chair: Professor Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Professor Jo Dumville.
Left Meeting: Professor Nicholas James
NIHR131805: The clinical and cost-effectiveness of a guided self-help cognitive behavioural therapy intervention to reduce dental anxiety in children
(Professor Zoe Marshman, The University of Sheffield)
Committee recommendation: Shortlist
Wednesday 15 July 2020 (Day 2)
Place
Virtual Meeting via Microsoft Teams
Present members
Professor Andrew Farmer (Chair)
Professor Olivia Wu (Deputy Chair)
Professor Hywel Williams (Programme Director)
Professor Julie Brittenden
Professor Matthew Costa
Dr Fay Crawford
Professor Jo Dumville
Professor Nick Francis
Professor Caroline Free
Professor Colin Green
Professor Kerenza Hood
Professor Nick James
Professor Asma Khalil
Professor Steff Lewis
Dr Rumana Omar
Professor Rupert Pearse
Professor Mark Peters
Professor Craig Ramsay
Mrs Amanda Roberts (PPI)
Professor Christine Roffe
Associate Professor Jo Thompson-Coon
Dr Sarah Stock
Dr Sara Twaddle
Dr Whitney Scott
Mr Dave Green (PPI)
NETSCC, HTA Secretariat
Dr Simon Fraser (Consultant Advisor).
Steph Garfield-Birkbeck (Head of the HTA Programme
Karen Williams (Senior Research Manager)
Cristina Lujan Barroso (Research manager)
Louisa Saunders (Assistant Research Manager)
Julie Herring (Administrator)
Apologies
Professor Simon Gates, Dr Marc Serfaty
Observers
Dr Julie McCaroll (NI Devolved Administration Rep).
Quoracy Information
Voting members: 26 Quorum = 18
Voting members present on Day 2: 24 (92%)
HTA Data Enabled Trials Call Stage 1 Proposals
19/109 HTA Call for ambitious data-enabled trials, health services and public health research studies
Chair: Professor Olivia Wu
Declared a conflict and did not partake in the discussion or vote: Professor Andrew Farmer, Professor Craig Ramsay, Professor Matthew Costa
NIHR130565: DIRECT Study: a highly pragmatic, efficient, whole population randomised trial of thromboprophylaxis in hip fracture.
(Associate Professor Xavier Griffin, University of Oxford)
Committee recommendation: Decline
Researcher-Led Stage 1 proposals
19/160 HTA Researcher-led call Primary Research
NIHR131861: RadiO fRequency ablatION for haemorrhoids (ORION)
(Professor Steven Brown, Sheffield Teaching Hospitals NHS Foundation Trust)
Chair: Professor Andrew Farmer
Declared a conflict: None
Committee recommendation: Shortlist
NIHR131808: Glaucoma Risk Prediction in ocular hypertension (GRIP): a cohort study using electronic medical records to validate a risk predictor and determine the cost-effectiveness of different monitoring schemes according to risk of conversion to glaucoma
(Professor Augusto Azuara-Blanco, Queen's University Belfast)
Chair: Professor Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Professor Craig Ramsay, Professor Kerenza Hood.
Declared a conflict and left the call: Professor Hywel Williams
Left meeting: Dr Julie McCaroll (Observer)
Committee recommendation: Shortlist
NIHR131887: EValuatIng DiurEtics in Normal CarE (EVIDENCE): - a cluster randomised study of comparative effectiveness of prescribing policy for thiazide-like drugs used for primary hypertension
(Dr Alexander Doney, University of Dundee)
Chair: Professor Andrew Farmer
Declared a conflict: None
Arrived meeting: Steph Garfield-Birkbeck, Dr Julie McCaroll (Observer)
Committee recommendation: Decline
NIHR131850: The clinical and cost-effectiveness of elective primary total knee replacement with patellar resurfacing compared to selective patellar resurfacing. A pragmatic multicentre randomised controlled trial with blinding
(Professor Ashley Blom, University of Bristol)
Chair: Professor Olivia Wu
Declared a conflict: None
Committee recommendation: Shortlist
NIHR131647: Randomised controlled trial of the Community Navigator programme to reduce loneliness and depression for adults with treatment resistant depression in secondary mental health services
(Dr Brynmor Lloyd Evans, University College London)
Chair: Professor Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Professor Rumana Omar
Committee recommendation: Shortlist
NIHR131873: Engaging patients to improve the management of toxicity during and after pelvic radiotherapy for gynaecological and anorectal cancers.
Randomised controlled trial of eHealth intervention: eRAPID (Electronic patient self-Reporting of Adverse-events: Patient Information and aDvice)
(Professor Galina Velikova, University of Leeds)
Chair: Professor Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: None
Committee recommendation: Decline
NIHR131222: An Adapted Home-Based Cardiac Rehabilitation Programme for Acute Secondary Prevention following a TIA and 'Minor' Stroke: A Randomised Controlled Trial
(Dr Neil Heron, Keele University)
Chair: Professor Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Professor Caroline Free, Professor Christine Roffe, Professor Olivia Wu
Committee recommendation: Decline
NIHR131889: A randomised registry-based open label study to assess change in respiratory function for people with cystic fibrosis (pwCF) with one or two Phe508del variants established on triple CFTR modulator combination therapy after rationalisation of muco-active aerosolised therapies (the CF STORM study)
(Professor Kevin Southern, University of Liverpool)
Chair: Professor Olivia Wu
Declared a conflict and did not partake in the discussion or vote: Professor Andrew Farmer, Professor Kerenza Hood
Declared a conflict and left the call: Professor Hywel Williams
Committee recommendation: Shortlist
NIHR131857: A randomised controlled trial assessing the clinical and cost effectiveness of compression HOSiery to Treat varicose vein Symptoms - the HOSTS study
(Professor Alun Davies, Imperial College London)
Chair: Professor Olivia Wu
Declared a conflict and did not partake in the discussion or vote: Professor Andrew Farmer, Professor Craig Ramsay, Professor Jo Dumville, Professor Steff Lewis, Dr Sarah Stock
Left meeting: Steph Garfield-Birkbeck
Committee recommendation: Decline
NIHR131698: Five year outcomes of infants, children and young people randomised to treatment with continuous subcutaneous insulin infusion or multiple daily insulin injections at diagnosis of type I diabetes
(Professor Joanne Blair, Alder Hey Children's NHS Foundation Trust)
Chair: Professor Olivia Wu
Declared a conflict and did not partake in the discussion or vote: Professor Andrew Farmer, Professor Kerenza Hood, Professor Nick Francis
Committee recommendation: Decline
NIHR131872: Endoscopic Vein Harvest versus Open Vein Harvest in Coronary Artery Bypass Grafting: a multi-centre randomised controlled trial (UK EVH Trial)
(Mr Enoch Akowuah, South Tees Hospitals NHS Foundation Trust)
Chair: Professor Olivia Wu
Declared a conflict and did not partake in the discussion or vote: Professor Andrew Farmer
Committee recommendation: Decline
NIHR131865: RandomisEd Trial of EarLy craniopLasty (RETELL study)
(Professor Peter Hutchinson, University of Cambridge)
Chair: Professor Andrew Farmer
Declared a conflict and did not partake in the discussion or vote: Professor Rumana Omar, Professor Christine Roffe
Left meeting: Professor Hywel Williams
Committee recommendation: Shortlist
19/161 HTA Researcher-led call Evidence Synthesis
NIHR131811: High-intensity interval training for prevention and treatment of non-communicable diseases: A mixed methods evidence synthesis
(Dr Paul Swinton, Robert Gordon University)
Chair: Professor Andrew Farmer
Left meeting: Professor Asma Khalil, Dr Sarah Stock, Professor Colin Green.
Committee recommendation: Decline