Meeting
HTA Funding Committee (General)
Day 1: 12 March 2024
Venue
Virtual via Microsoft Teams
Present Members
Catherine Hewitt (Chair)
Mark Peters (Deputy Chair)
Marta Soares
Stephanie MacNeill
Ben Carter
Athanasios Saratzis
Michelle Collinson
Hema Mistry
Mohamed Abdel-Fattah
Abdullah Pandor
David Harrison
Peter Watkinson
Ashley Agus
Joyce Yeung
David Keene
Rachel Stockley (Committee Member Development Scheme Participant)
Garry Barton
Anthony Kendrick
David Green (Public Committee member)
Richard Riley
Khalida Ismail
Harm Van Marwijk
Victoria Goodwin
Hashim Ahmed
Joanna Thompson-Coon
Matthew Moore (Public Committee member)
Dawn-Marie Walker
Sarah Markham (Public Committee member)
Jugdeep Dhesi
Secretariat
Jason Horsley (Consultant Advisor)
Helen Payne (Senior Research Manager)
Anna Cutler (Senior Research Manager)
Kathy Tier (Research Manager)
Louisa Saunders (Assistant Research Manager)
Debbie Carter (Administrator)
Apologies
Andrew Farmer (Programme Director)
Stuart McIntosh
Observers
Janet Diffin NI Devolved Administration representative
Lynn Calman (Incoming Committee Member Development Scheme Participant)
Ruchi Baxi – new Consultant Advisor
Clare Eyres – new SRM for HTA Applications & Funding
Sarah Heath – new administrator for HTA General Funding Committee
Quoracy Information
- Voting members: 30 (inclusive of Chairs and all voting Committee members)
- Quorum (all voting members minus a Chair) = 19 = 66%
- Emergency Quorum (all voting members minus a Chair) = 14 = 50%
- Voting members present on Day 1: 29
Stage 2 Applications
23/1 HTA Researcher-led call Primary Research
NIHR159009 - LACunar Intervention (LACI) Trial-3: Assessment of efficacy and safety of cilostazol and isosorbide mononitrate to prevent adverse outcomes in patients with cerebral small vessel disease (lacunar) ischaemic stroke
- Chair: Catherine Hewitt
- Declared a conflict and left the meeting: Hema Mistry, Mark Peters
- Arrived at the meeting: Sarah Markham
- Decision: Programme Oversight Committee to consider fund with changes
23/64 HTA Researcher-led call Evidence Synthesis
NIHR160844 - An EvideNce synthesis of Acceptance & Commitment Therapy for improving distress in long-term health conditions (ENACT): Exploring effectiveness, cost-effectiveness, with evidence & gap mapping to inform clinical practice
- Chair: Mark Peters
- Declared a conflict and left the meeting: Athanasios Saratzis, Michelle Collinson, Abdullah Pandor, Ashley Agus, Khalida Ismail
- Decision: Decline
NIHR161575 - Non-surgical interventions for pelvic organ prolapse in women: a component network meta-analysis and cost-effectiveness analysis
- Chair: Mark Peters
- Declared a conflict and left the meeting: Mohamed Abdel-Fattah, Hashim Ahmed
- Decision: Programme Oversight Committee to consider fund with changes
HTA Commissioned Calls
22/96 Urine sampling in children
NIHR156005 - Determining the feasibility of randomising children and young people to invasive and non-invasive urine sampling techniques.
- Chair: Catherine Hewitt
- Declared a conflict and left the meeting: Athanasios Saratzis, Hema Mistry, David Harrison, Ashley Agus, Mark Peters
- Decision: Programme Oversight Committee to consider fund with changes
23/43 Management of severe acute asthma in children
NIHR162027 - A randomised trial of aminophylline, magnesium sulfate or salbutamol intravenous therapy for acute severe asthma in children and young people.
- Chair: Catherine Hewitt
- Declared a conflict and left the meeting: Athanasios Saratzis, Michelle Collinson, Mohamed Abdel-Fattah, David Harrison, Anthony Kendrick, Hashim Ahmed, Mark Peters
- Decision: Programme Oversight Committee to consider fund with changes
23/44 Effectiveness of oral nutritional supplements in older adults with malnutrition
- Chair: Catherine Hewitt
- Declared a conflict and left the meeting: David Keene, Victoria Goodwin, Joanna Thompson-Coon, Dawn-Marie Walker, Michelle Collinson, David Harrison, Ashley Agus, Joyce Yeung, Jugdeep Dhesi, Mark Peters
NIHR160348 – REFRESH study: REFRESH study: nutRition intervEntions For malnouRished oldEr adultS in care Homes - A parallel, superiority, three-arm cluster randomised controlled trial.
- Decision: Programme Oversight Committee to consider fund with changes
NIHR160451 – Building Independence with Creatine and Energy supplements in older Patients undergoing SURGery (BICEP-SURG)
- Decision: Decline
Stage 1 Applications
HTA Commissioned Calls
23/101 Early detection of liver disease
NIHR165852 - DIALS – DIAgnosis of Liver diseaSe in primary care
- Chair: Catherine Hewitt
- Declared a conflict and left the meeting: Hema Mistry, David Keene, Victoria Goodwin, Mark Peters
- Left the meeting: Matthew Moore
- Decision: Shortlist
23/102 DOAC thromboprophylaxis during treatment for lung cancer
- Chair: Mark Peters
- Declared a conflict and left the meeting: Hema Mistry, Joyce Yeung, Michelle Collinson, Catherine Hewitt, Ben Carter, Hashim Ahmed, Richard Riley
- Arrived at the meeting: Matthew Moore
- Left the meeting: Stephanie MacNeill
NIHR164632 - A Placebo controlled Randomised Phase III Trial Investigating the Direct-acting Oral Anticoagulant Apixaban for Primary Thromboprophylaxis of Lung Cancer Patients Receiving Systemic Anticancer Treatments: ‘NOMADIC’
- Decision: Shortlist
NIHR165646 - Apixaban thromboprophylaxis to prevent venous thromboembolism in ambulatory lung cancer patients undergoing systemic anticancer treatment.
- Decision: Shortlist
NIHR165804 - A randomised phase III placebo-controlled trial of ApixabaN Thromboprophylaxis in people receiving treatment for with Lung cancER (ANTLER)
- Decision: Decline
HTA Broad Brief Calls
23/100 Management of gastro-oesophageal reflux in infants
NIHR165206 - Omeprazole for Treatment of Term and preterm infants with gastro-oEsophageal Reflux (OTTER)
- Chair: Catherine Hewitt
- Declared a conflict and left the meeting: Thanasios Saratzis, Hema Mistry, Garry Barton, Anthony Kendrick, Mark Peters, Dawn-Marie Walker
- Decision: Shortlist
23/99 Interventions to reduce Antimicrobial Resistance (AMR)
NIHR163883 - The DURACELL trial. Optimal duration of antibiotic therapy for effectiveness, safety and selection of antibiotic resistance in adults with lower limb cellulitis: a randomised controlled trial.
- Chair: Catherine Hewitt
- Declared a conflict and left the meeting: Marta Soares, David Harrison, Peter Watkinson, Harm Van Marwijk
- Left the meeting: Michelle Collinson, Anthony Kendrick
- Decision: Decline
NIHR165037 - DEcision Aids to Limit antibiotic prescription with common infections to combat AntiMicrobial Resistance (DEAL with AMR)
- Chair: Mark Peters
- Declared a conflict and left the meeting: Ben Carter, Mohamed Abdel-Fattah, Peter Watkinson, Garry Barton, Anthony Kendrick, Harm Van Marwijk, Dawn-Marie Walker
- Arrived at the meeting: Stephanie MacNeill
- Decision: Decline
Day 2: 13 March 2024
Venue
Virtual via Microsoft Teams
Present Members
Catherine Hewitt (Chair)
Mark Peters (Deputy Chair)
Andrew Farmer (Programme Director)
Stephanie MacNeill
Ben Carter
Athanasios Saratzis
Michelle Collinson
Hema Mistry
Mohamed Abdel-Fattah
Abdullah Pandor
David Harrison
Peter Watkinson
Ashley Agus
Joyce Yeung
David Keene
Rachel Stockley (Committee Member Development Scheme Participant)
Garry Barton
Anthony Kendrick
David Green (Public Committee Member)
Richard Riley
Khalida Ismail
Harm Van Marwijk
Victoria Goodwin
Joanna Thompson-Coon
Matthew Moore (Public Committee Member)
Dawn-Marie Walker
Sarah Markham (Public Committee Member)
Jugdeep Dhesi
Secretariat
Jason Horsley (Consultant Advisor)
Helen Payne (Senior Research Manager)
Kathy Tier (Research Manager)
Louisa Saunders (Assistant Research Manager)
Gill Watson (Assistant Research Manager)
Apologies
Hashim Ahmed
Stuart McIntosh
Marta Soares
Observers
Janet Diffin NI Devolved Administration representative
Lynn Calman (Incoming Committee Member Development Scheme Participant)
Ruchi Baxi – new Consultant advisor
Clare Eyres – new SRM for HTA applications & Funding
Quoracy Information
- Voting members: 30 (inclusive of Chairs and all voting Committee members)
Quorum (all voting members minus a Chair) = 19 = 66%
Emergency Quorum (all voting members minus a Chair) = 14 = 50%
Voting members present on Day 1: 27
HTA Broad Briefs
23/99 Interventions to reduce Antimicrobial Resistance (AMR)
NIHR165318 - EVOLUTION Trial: EValuating a nOveL UTI dIagnOstic for aNtibiotic stewardship
- Chair: Catherine Hewitt
- Declared a conflict and left the meeting: Peter Watkinson, Andrew Farmer
- Decision: Shortlist
NIHR163402 - Amoxicillin for acute Lower respiratory tract infections in Patients with Asthma: the ALPA non-inferiority, individually randomised, placebo controlled trial
- Chair: Catherine Hewitt
- Declared a conflict and left the meeting: Stephanie MacNeill, Ben Carter, Anthony Kendrick
- Arrived at the meeting: Matthew Moore, Khalida Ismail
- Decision: Decline
NIHR164573 - Randomised controlled trial of ultra-short course antibiotics compared to usual care for clinically stable adult patients with suspected hospital-acquired pneumonia: ULTRA-HAP
- Chair: Mark Peters
- Declared a conflict and left the meeting: Catherine Hewitt, David Harrison, Ashley Agus, Sarah Markham
- Decision: Decline
NIHR165594 - Antifungals - Stopping Early with a Fungal Biomarker-based Stewardship Algorithm in Critical Care. (The A-Stop 2 Trial)
- Chair: Catherine Hewitt
- Declared a conflict and left the meeting: Hema Mistry, Abdullah Pandor, David Harrison, Peter Watkinson, Ashley Agus, David Keene, Mark Peters
- Arrived at the meeting: Sarah Markham
- Decision: Resubmission
23/111 HTA Researcher-led call Evidence Synthesis
NIHR164555 - Valuing Intravitreal Technologies Across Every indication (VITAE): evidence synthesis and cost–utility analysis
- Chair: Catherine Hewitt
- Declared a conflict and left the meeting: Marta Soares, Athanasios Saratzis, David Keene, Andrew Farmer, Victoria Goodwin, Joanna Thompson-Coon
- Decision: Decline
NIHR163550 - Systematic literature review, evidence synthesis and economic modelling of weight loss drugs, lifestyle interventions and surgery for adults with obesity
- Chair: Catherine Hewitt
- Declared a conflict and left the meeting: Mohamed Abdel-Fattah, Athanasios Saratzis
- Arrived at the meeting: Lynn Calman
- Decision: Resubmission
NIHR164633 - Confirming the placement of nasogastric tubes: a systematic review and economic evaluation
- Chair: Catherine Hewitt
- Declared a conflict and left the meeting: Rachel Stockley
- Left the meeting: Matthew Moore
- Decision: Decline
NIHR164786 - PROTECT: A systematic review and cost-effectiveness model to assess the feasibility of a screening program for neovascular age-related macular degeneration
- Chair: Mark Peters
- Declared a conflict and left the meeting: Athanasios Saratzis, Catherine Hewitt
- Arrived at the meeting: Matthew Moore
- Decision: Shortlist
23/110 HTA Researcher-led call Primary Research
NIHR163627 - ADEPT: Amitriptyline and Duloxetine Evaluation in Primary care Treatment of chronic pain
- Chair: Mark Peters
- Declared a conflict and left the meeting: Lynn Calman, Stephanie MacNeill, Garry Barton, Anthony Kendrick, Victoria Goodwin, Dawn-Marie Walker
- Decision: Decline
NIHR163836 - Pre-Operative Radiotherapy and Deep Inferior Epigastric Perforator Flap Reconstruction Trial (PRADA-II Trial)
- Chair: Catherine Hewitt
- Declared a conflict and left the meeting: Ben Carter
- Arrived at the meeting: Joyce Yeung
- Decision: Shortlist
NIHR165425 - Home-based transcranial direct current stimulation in major depressive disorder: a multi-centre, two-parallel group, controlled, superiority randomised controlled trial
- Chair: Catherine Hewitt
- Declared a conflict and left the meeting: Ben Carter, Anthony Kendrick, Khalida Ismail, Sarah Markham
- Decision: Shortlist