Day 1 - 11 July 2023
Venue
Danubius Hotel Regents Park, 18 Lodge Road, London NW8 7JT
Present members
- Julia Brown (Chair)
- Mark Peters (Deputy Chair)
- Andrew Farmer (Programme Director)
- David Green (Public Committee Member)
- Ashley Agus
- Hashim Ahmed
- Jo Dumville
- Simon Gates
- David Keene
- Stephanie MacNeill
- Marta Soares
- Joanna Thompson-Coon
- Khalida Ismail
- Hema Mistry
- Dawn-Marie Walker
- Athanasios Saratzis
- Stuart McIntosh
- David Harrison
- Ben Carter
- Abdullah Pandor
- Thomas Hellyer (Committee Member Development Scheme Participant)
- Garry Barton
- Victoria Goodwin
- Joyce Yeung
- Sarah Markham (Public Committee Member)
- Mohamed Abdel-Fattah
- Jugdeep Dhesi
- Caroline Free
Secretariat
- Vicky Taylor
- James Morris
- Daniel Housego
- Louisa Saunders
Apologies
- Nick Francis
- Matthew Moore (Public Committee Member)
Observers
- None
Quoracy information
- Voting members: 29
- Quorum = 18 = 66%
- Emergency Quorum = 14 = 50%
- Voting members present on Day 1: 27
Stage 2 applications
22/4 NIHR JLA Rolling Call (resubmission)
NIHR153258 - DEBI: clinical and cost-effectiveness of desogestrel versus the combined oral contraceptive pill for problematic bleeding on the etonogestrel implant (Kate Walker)
Chair: Julia Brown
Conflicts: Hema Mistry, Joyce Yeung. Caroline Free
Decision: Programme Oversight Committee to consider fund with changes
22/64 NIHR JLA Rolling Call (resubmission)
NIHR155220 - A multi-centre double-blind randomised placebo-controlled group-sequential superiority trial to assess the effectiveness and cost-effectiveness of oral Corticosteroids in patients witH fibrOtic hypeRsensitivity pneUmonitiS (CHORUS). (Michael Gibbons, Philip Molyneaux)
Chair: Julia Brown
Conflicts: Ashley Agus, David Harrison, Thomas Hellyer, Victoria Goodwin, David Keene, Joanna Thompson-Coon, Garry Barton
Decision: Programme Oversight Committee to consider fund with changes
22/3 NIHR NICE Rolling Call (resubmission)
NIHR152845 - SORTED Surgery Or Rehabilitation for Traumatic shouldEr Dislocations (Stephen Gwilym, Rebecca Kearney)
Chair: Julia Brown
Conflicts: Andrew Farmer, Hema Mistry, David Keene, Stephanie MacNeill, Joyce Yeung
Left the meeting: Joanna Thompson-Coon, Marta Soares
Decision: Decline
22/99 Clinical prediction models for early-onset neonatal infection
NIHR154983 - Clinical pRediction model for eArlY-onset neOnatal iNfection: The CRAYON study. A cluster randomised trial and validation study of the Sepsis Risk Calculator with health economic and acceptability evaluations. (Sabita Uthaya)
Chair: Julia Brown
Conflicts: Ashley Agus, Hema Mistry, David Harrison, Simon Gates, Andrew Farmer, Mark Peters
Decision: Decline Return to POC
22/95 Chronic kidney disease education for patients, families and carers
Chair: Mark Peters
Conflicts: David Keene, Joanna Thompson-Coon, Hema Mistry, Abdullah Pandor, Victoria Goodwin, Khalida Ismail, Marta Soares, Julia Brown
NIHR157760 - Does current provision of information and education to patients, families and carers in the UK with CKD Stages 2-4 align with evidence on effectiveness and cost-effectiveness, and what factors affect provision and uptake? (Peter Knapp)
Decision: Decline
NIHR157908 - Mixed Method Evidence Synthesis for Equity: to identify inclusive education and information interventions for all people managing early-stage chronic kidney disease (Paula Ormandy, Joanna Thompson-Coon)
Decision: Fund
22/113 HTA Programme Researcher-led call Evidence Synthesis
NIHR156203 - Confirming the placement of nasogastric tubes: a systematic review and economic evaluation (Elizabeth Lightbody)
Chair: Julia Brown
Conflicts: Jo Dumville
Arrived at the meeting: Marta Soares
Decision: Decline
Stage 1 applications
23/1 HTA Researcher-led call Primary Research
NIHR159566 - A pragmatic randomised controlled trial of serial prophylactic exchange blood transfusion (SPEBT) compared to standard care in pregnant women with sickle cell disease aiming to improve maternal and infant outcomes. (Eugene Oteng-Ntim)
Chair: Mark Peters
Conflicts: Khalida Ismail, Athanasios Saratzis, Caroline Free
Decision: Decline
NIHR158382 - ADEPT: Amitriptyline and Duloxetine Evaluation in Primary care Treatment of chronic pain (Tamar Pincus, Hazel Everitt)
Chair: Mark Peters
Conflicts: Jo Dumville, Stephanie MacNeill, Dawn-Marie Walker, Garry Barton, Victoria Goodwin
Decision: Decline
NIHR158668 - A randomised controlled trial of no routine gastric residual volume measurements compared to regular measurements to guide enteral feeding in mechanically ventilated adults: the STOP GRV trial? (Lyvonne Tume, Tamas Szakmany)
Chair: Julia Brown
Conflicts: Ashley Agus, Simon Gates, Thomas Hellyer, Mark Peters, Hema Mistry, Joyce Yeung, Stuart McIntosh, David Harrison
Decision: Decline
NIHR159450 - Clinical and cost-effectiveness trial of hybrid or cemented implants for total hip replacement in older adults. Acronym: HipHOP2 (Hip arthroplasty with Hybrid Or cemented implants: Patient reported outcomes) (Tim Board, Hiren Divecha)
Chair: Julia Brown
Conflicts: David Keene, Stephanie MacNeill, Stuart McIntosh
Left the meeting: Garry Barton
Decision: Decline
NIHR159223 - The clinical and cost effectiveness of tight versus less tight glycaemic control around the time of birth in pregnancies complicated by gestational diabetes: the GILD trial (Eleanor Mitchell, Kate Walker)
Chair: Mark Peters
Conflicts: Khalida Ismail, Hema Mistry, Garry Barton, Andrew Farmer, Athanasios Saratzis
Arrived at the meeting: Joanna Thompson-Coon
Decision: Shortlist
NIHR158052 - Long-term outcomes of the Treatment of Advanced Glaucoma Study (TAGS): A multicentre randomised controlled trial comparing primary medical treatment with primary trabeculectomy for people with newly diagnosed advanced glaucoma (Anthony King)
Chair: Julia Brown
Conflicts: Hashim Ahmed, Hema Mistry, Stuart McIntosh
Arrived at the meeting: Garry Barton
Decision: Shortlist
Day 2 - 12 July 2023
Venue
Danubius Hotel Regents Park, 18 Lodge Road, London NW8 7JT
Present members
- Julia Brown (Chair)
- Mark Peters (Deputy Chair)
- Andrew Farmer (Programme Director)
- David Green (Public Committee Member)
- Ashley Agus
- Hashim Ahmed
- Jo Dumville
- Simon Gates
- David Keene
- Stephanie MacNeill
- Marta Soares
- Joanna Thompson-Coon
- Khalida Ismail
- Hema Mistry
- Dawn-Marie Walker
- Athanasios Saratzis
- Stuart McIntosh
- David Harrison
- Ben Carter
- Abdullah Pandor
- Thomas Hellyer (Committee Member Development Scheme Participant)
- Garry Barton
- Victoria Goodwin
- Joyce Yeung
- Sarah Markham (Public Committee Member)
- Mohamed Abdel-Fattah
- Jugdeep Dhesi
- Caroline Free
Secretariat
- Vicky Taylor
- James Morris
- Daniel Housego
- Louisa Saunders
Apologies
- Nick Francis
- Matthew Moore (Public Committee Member)
Observers
- None
Quoracy information
- Voting members: 29
- Quorum = 18 = 66%
- Emergency Quorum = 14 = 50%
- Voting members present on Day 1: 27
23/1 HTA Researcher-led call Primary Research (Continued)
NIHR159674 - “I can’t ignore this any more”: supported self-care for women with urinary and / or faecal symptoms. (Ifeoma Offiah, Marcus Drake)
Chair: Julia Brown
Conflicts: Mohamed Abdel-Fattah, Hashim Ahmed, Stephanie MacNeill, Athanasios Saratzis
Decision: Decline
NIHR158894 - Clinical and Cost-effectiveness of Family-Focused Treatment for Young People at Clinical High Risk for Psychosis (Louise Johns, Belinda Lennox)
Chair: Julia Brown
Conflicts: Andrew Farmer
Decision: Decline
23/2 HTA Researcher-led call Evidence Synthesis
NIHR159253 - REhabilitation of upper limb function using diGital heAlth technologies during the first six months after stroke: a systematIc review and economic evaluatioN (REGAIN) (Rachel Stockley, Andrew Clegg)
Chair: Mark Peters
Conflicts: Jo Dumville
Decision: Decline
23/3 NIHR NICE Rolling Call
NIHR159009 - LACunar Intervention (LACI) Trial-3: Assessment of efficacy and safety of cilostazol and isosorbide mononitrate to prevent adverse outcomes in patients with cerebral small vessel disease (lacunar) ischaemic stroke (Joanna Wardlaw, Philip Bath)
Chair: Julia Brown
Conflicts: Hema Mistry, Athanasios Saratzis, Mark Peters
Decision: Shortlist
NIHR159321 - DIRECT: Delivery and Implementation of a Randomised Cluster Crossover Trial on Thrombosis (Xavier Griffin)
Chair: Julia Brown
Conflicts: Abdullah Pandor, Joyce Yeung, David Keene, Andrew Farmer
Decision: Shortlist
23/5 Management of bone metastasis and skeletal related events (SREs) in patients with advanced cancer
NIHR159676 - The PORTRAIT trial – Post-operative radiotherapy in surgically treated bone metastases (Jonathan Stevenson)
Chair: Mark Peters
Conflicts: Jo Dumville, Marta Soares, Julia Brown
Decision: Shortlist
NIHR159393 - Short-term bracing for newly diagnosed spinal myeloma: A phase III randomised controlled trial Short title: BrACing in BONy mEtastases (BACBONE) -myeloma (Stella Bowcock, Guy Pratt)
Chair: Mark Peters
Conflicts: Hema Mistry, Simon Gates, Joyce Yeung, Khalida Ismail
Decision: Shortlist
22/170 Testosterone for the treatment of menopause symptoms beyond altered sexual function
Chair: Julia Brown
Conflicts: Hashim Ahmed, Hema Mistry, Athanasios Saratzis, Joyce Yeung, Mohamed Abdel-Fattah, Mark Peters, Abdullah Pandor
NIHR159463 - INitiation of Testosterone in addition to Estrogen to aLLevitae menopause affEct on CogniTion: INTELLECT (Channa Jayasena, Haitham Hamoda)
Decision: Decline
NIHR159679 - The TRIM (Testosterone Replacement in Menopause) trial: A randomised controlled trial to evaluate the clinical-effectiveness, cost-effectiveness and safety of testosterone gel for women with menopause symptoms beyond altered sexual function (Mostafa Metwally)
Decision: Shortlist
NIHR159538 - ESTEEM - Evaluating the clinical and cost-effectivenesS of TEstosteronE to improve Menopause-related quality of life (Michael Robling, Christina Munro)
Decision: Shortlist
23/4 NIHR JLA Rolling Call
NIHR159389 - A randomised controlled trial to assess the clinical and cost-effectiveness of PSMA PET imaging to stage newly diagnosed high risk prostate cancer compared to standard care CT and bone-scan imaging (Hashim Ahmed, Martin Connor)
Chair: Julia Brown
Conflicts: Marta Soares, Hashim Ahmed
Left the meeting: Mohamed Abdel-Fattah
Decision: Decline
NIHR159316 - High INtensity Interval TraIning compAred To usual-care supervised Exercise programmes for paTients With intermittent claudicatiOn (INITIATE-TWO): A randomised controlled trial (Sean Pymer, Ian Chetter)
Chair: Mark Peters
Conflicts: Jo Dumville, Marta Soares, Joyce Yeung, Athanasios Saratzis
Decision: Decline
NIHR159391 - ClinIcal and Cost-Effectiveness of full-leg coMpared with proximAl-leG ultrasound whEn stratified based on pre-test probability/Wells score to diagnose Deep Vein Thrombosis: (IMAGE-DVT) (Steven Rogers, Sean Gavan)
Chair: Mark Peters
Conflicts: Abdullah Pandor, Thomas Hellyer, Athanasios Saratzis
Decision: Decline
NIHR158606 - Pathway for Atrial Fibrillation Detection and Anticoagulation delivered by Hyperacute Stroke Units using Electrocardiogram Patches (PATCHES) (Alan Cameron)
Chair: Julia Brown
Conflicts: Simon Gates, Victoria Goodwin
Decision: Decline
NIHR159478 - ESTABLISH - Endovascular versus Surgical Treatment for Acute Lower Limb Ischaemia; a clinical and cost-effectiveness study (Sandip Nandhra, Athanasios Saratzis)
Chair: Julia Brown
Conflicts: Hashim Ahmed, Jugdeep Dhesi, Thomas Hellyer, Mohamed Abdel-Fattah, Athanasios Saratzis
Decision: Decline